Selective expression of aski transgene affects IIb fast muscles and skeletal structure

Peroxisome Proliferator-activated Receptor γ (PPARγ) Mediates a Ski Oncogene-induced Shift from Glycolysis to Oxidative Energy Metabolism

“…Studies of Ski transgenic mice show that Ski regulates body composition by increasing type IIb muscle fibers in which Ski is selectively overexpressed, while decreasing adipose tissue mass (60,61). A more recent analysis of the affected muscles in those mice demonstrated a decreased expression of several genes involved in lipid synthesis, indicating that Ski suppresses lipogenesis, consistent with our findings in Ski-CEFs (17).…”

From insect eye to vertebrate muscle: redeployment of a regulatory network

“…The skeletal muscle mass is also reduced in the mutant. Over expression of Ski results in skeletal muscle hypertrophy (Sutrave et al 1990), with fast fibers particularly implicated (Lana et al 1996). Sno, like Ski, is expressed in many tissues, including neonatal and adult skeletal muscle (Pearson-White and Crittenden 1997).…”

Studies on Expression of the c-ski Gene in Equine (Thoroughbred) Tissues.

“…The cellular proto-oncogene, c-ski, encodes a nuclear protein, SKI, which possesses a leucine zipper-like structure [7] and is capable of transforming embryonic fibroblasts to cells of myogenic lineage in quails [2]. Furthermore, in transgenic mice [4,14] and cattle [1] created by introducing a truncated chicken c-ski gene, selective growth of skeletal muscles take place postnatally. Although the exact roles played by SKI in the pathways of myogenic differentiation or in the differentiated myogenic cells are yet unknown, it can reasonably be suspected that SKI might play a role in the regeneration of skeletal muscle fibres in mammals including race horses.…”