Selective Formation of Active Cobalt Species for Direct Methylation of Benzene with Methane on MFI Zeolite by Co-presence of Secondary Elements

Matsubara, Hitoshi; Tsuji, Etsushi; Moriwaki, Yasumi; Okumura, Kazu; Yamamoto, Kana; Nakamura, Koshiro; Suganuma, Satoshi; Katada, Naonobu

doi:10.1007/s10562-019-02855-y

Cited by 13 publications

(2 citation statements)

References 41 publications

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“…Notably, the CoNC synthesized from precursors containing only Co-doped showed no activity, likely due to Co aggregation resulting from the absence of ZIF-8 structure formation and the high Co content (Figure S9). 31 To elucidate the role of Co in the NOX-like activity, we compared the activity between CoNC and NC (non Codoped). As depicted in Figure S10, NC was capable of oxidizing NADH, though at a significantly lower rate than CoNC.…”

Section: ■ Introductionmentioning

confidence: 99%

Innovative Colorimetric NQO1 Detection Strategy via Substrate Competitive and Biomimetic Cascade Reactions with a Highly Active NADH Oxidase Mimic

Fang,

Liu,

Song

et al. 2024

Anal. Chem.

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NAD(P)H: quinone oxidoreductase-1 (NQO1) plays critical roles in antioxidation and abnormally overexpresses in tumors. Developing a fast and sensitive method of monitoring NQO1 will greatly promote cancer diagnosis in clinical practice. This study introduces a transformative colorimetric detection strategy for NQO1, harnessing an innovative competitive substrate mechanism between NQO1 and a new NADH oxidase (NOX) mimic, cobalt−nitrogen-doped carbon nanozyme (CoNC). This method ingeniously exploits the differential consumption of NADH in the presence of NQO1 to modulate the generation of H 2 O 2 from CoNC catalysis, which is then quantified through a secondary, peroxidase-mimetic cascade reaction involving Prussian blue (PB) nanoparticles. This dual-stage reaction framework not only enhances the sensitivity of NQO1 detection, achieving a limit of detection as low as 0.67 μg mL −1 , but also enables the differentiation between cancerous and noncancerous cells by their enzymatic activity profiles. Moreover, CoNC exhibits exceptional catalytic efficiency, with a specific activity reaching 5.2 U mg −1 , significantly outperforming existing NOX mimics. Beyond mere detection, CoNC serves a dual role, acting as both a robust mimic of cytochrome c reductase (Cyt c) and a cornerstone for enzymatic regeneration, thereby broadening the scope of its biological applications. This study not only marks a significant step forward in the bioanalytical application of nanozymes but also sets the stage for their expanded use in clinical diagnostics and therapeutic monitoring.

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Section: ■ Introductionmentioning

confidence: 99%

Innovative Colorimetric NQO1 Detection Strategy via Substrate Competitive and Biomimetic Cascade Reactions with a Highly Active NADH Oxidase Mimic

Fang,

Liu,

Song

et al. 2024

Anal. Chem.

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“…Particularly, Co K-edge XAFS is powerful technique to obtain information on the structural and electronic state of the Co center, which has been applied for the characterization of Co/zeolites so far. 17,18 2. Experimental…”

Section: Introductionmentioning

confidence: 99%

Direct methylation of benzene with methane over Co/MFI catalysts generated by self-dispersion of Co(OH)₂

Okumura,

Tanaka,

Ohtsuki

et al. 2023

Catal. Sci. Technol.

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Frontiers in Arene Chemistry: Direct Methylation of Benzene with Methane on Metal‐Loaded Zeolites

Tsuji¹,

Katada

2023

Industrial Arene Chemistry

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Selective Formation of Active Cobalt Species for Direct Methylation of Benzene with Methane on MFI Zeolite by Co-presence of Secondary Elements

Cited by 13 publications

References 41 publications

Innovative Colorimetric NQO1 Detection Strategy via Substrate Competitive and Biomimetic Cascade Reactions with a Highly Active NADH Oxidase Mimic

Innovative Colorimetric NQO1 Detection Strategy via Substrate Competitive and Biomimetic Cascade Reactions with a Highly Active NADH Oxidase Mimic

Direct methylation of benzene with methane over Co/MFI catalysts generated by self-dispersion of Co(OH)₂

Frontiers in Arene Chemistry: Direct Methylation of Benzene with Methane on Metal‐Loaded Zeolites

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Selective Formation of Active Cobalt Species for Direct Methylation of Benzene with Methane on MFI Zeolite by Co-presence of Secondary Elements

Cited by 13 publications

References 41 publications

Innovative Colorimetric NQO1 Detection Strategy via Substrate Competitive and Biomimetic Cascade Reactions with a Highly Active NADH Oxidase Mimic

Innovative Colorimetric NQO1 Detection Strategy via Substrate Competitive and Biomimetic Cascade Reactions with a Highly Active NADH Oxidase Mimic

Direct methylation of benzene with methane over Co/MFI catalysts generated by self-dispersion of Co(OH)2

Frontiers in Arene Chemistry: Direct Methylation of Benzene with Methane on Metal‐Loaded Zeolites

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Direct methylation of benzene with methane over Co/MFI catalysts generated by self-dispersion of Co(OH)₂