Selective IgA Deficiency and Autoimmunity

Liblau, Roland; Bach, Jean‐François

doi:10.1159/000236330

Cited by 111 publications

(71 citation statements)

References 61 publications

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“…The prevalence of autoimmunity in IgAD individuals has been shown to be highly variable, ranging from 7% to 36% in symptomatic IgAD individuals (27), whereas the prevalence of autoimmune disorders in the general population is estimated to be between 3% and 5% (8,9). Recently, Jacob et al reported the frequency of autoimmunity as 19% in their sIgAD patients, which is similar to our results (28).…”

Section: Discussionsupporting

confidence: 90%

Allergic and autoimmune disorders in families with selective IgA deficiency

et al. 2017

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Background/aim: IgA deficiency is the most common human primary immunodeficiency. The prevalence of allergic disorders and autoimmunity is thought to be increased in selective IgA deficiency (sIgAD). However, it is currently unclear if these disorders coincide within these families. We aimed to evaluate the frequency of allergic and autoimmune disorders in children with sIgAD and their firstdegree relatives (FDRs). Materials and methods:The study included 81 children diagnosed with sIgAD and 274 of their FDRs. The presence of allergic and autoimmune disorders was evaluated and serum antithyroglobulin and antithyroid peroxidase levels were measured in both patients and their first-degree relatives. Results:The mean age of the patients was 9.9 ± 3.9 years. Among the patients with sIgAD, 45.7% of them had at least one allergic disorder and 17.3% of them had at least one autoimmune disorder. The frequencies of asthma, allergic rhinitis, and eczema in the FDRs of sIgAD patients were 10.9%, 9.1%, and 7.7%, respectively. Among their FDRs, 14.6% had autoimmunity, compared to an estimate of 5% in the general population. Conclusion:Increased frequency of allergic and autoimmune disorders in patients with sIgAD and their FDRs suggests a possible common predisposing genetic component for sIgAD and autoimmunity in these families.

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Section: Discussionsupporting

confidence: 90%

Allergic and autoimmune disorders in families with selective IgA deficiency

et al. 2017

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“…104 There is also a clear link between SIgAD and celiac disease. The prevalence of SIgAD in patients with celiac disease is 2.6%, which represents a 10-to 16-fold increase over that in the general population.…”

Section: Org Frommentioning

confidence: 99%

Autoimmunity in human primary immunodeficiency diseases

Arkwright

Abinun

Cant

2002

Blood

162

106

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Human primary immunodeficiency diseases are experiments of nature characterized by an increased susceptibility to infection. In many cases, they are also associated with troublesome and sometimes life-threatening autoimmune complications. In the past few years, great strides have been made in understanding the molecular basis of primary immunodeficiencies, and this had led to more focused and successful treatment. This review has 3 aims: (1) to highlight the variety of autoimmune phenomena associated with human primary immunodeficiency diseases; (2) to explore how primary immunodeficiencies predispose patients to autoimmune phenomena triggered by opportunistic infections; and (3) to consider the rationale for the current treatment strategies for autoimmune phenomena, specifically in relation to primary immunodeficiency diseases. Reviewing recent advances in our understanding of the small subgroup of patients with defined causes for their autoimmunity may lead to the development of more effective treatment strategies for idiopathic human autoimmune diseases. (Blood. 2002;99:2694-2702

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“…A característi ca não-infl amatória da ligação antí genosIgA é fundamental para a manutenção da integridade das mucosas, especialmente no trato gastrointesti nal, onde o indivíduo é exposto a uma grande variedade de antí genos provenientes dos alimentos 2 . Esta característi ca pode ser confi rmada em indivíduos que apresentam lesões infl amatórias gastrointesti nais devido ao aumento das células produtoras de IgG no intesti no, provavelmente causadas pelas enzimas lisossômicas secretadas pelas células polimorfonucleares que se ligam ao complexo antí geno-IgG 28 . Inibição da adesão bacteriana: Um pré-requisito para a patogênese de várias infecções bacterianas é a habilidade do microorganismo em aderir à superfí cie mucosa do hospedeiro.…”

Section: Funções Da Sigaunclassified

O Papel da Imunoglobulina A Secretora no Mecanismo de Defesa da Mucosa Bucal

Campos¹,

Ferreira²,

Vitral³

2011

Pesq Bras Odontoped Clin Integr

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RESUMO ABSTRACTImunoglobulina A secretora; Sistema imune; Mucosa bucal. Immunoglobulin A, secretory; Immune system; Oral mucosa. DESCRITORES KEYWORDSIntrodução: As superfí cies mucosas mantêm contato direto com o meio externo, sendo expostas a uma grande variedade de antí genos. Essas superfí cies possuem relati va vulnerabilidade e a secreção de anti corpos pelo sistema imune de mucosa consti tui sua principal defesa, mantendo os antí genos desconhecidos e/ou potencialmente patogênicos fora do organismo. Entre esses anti corpos, o mais abundante é uma IgA polimérica, denominada IgA secretora, que é produzida por plasmócitos associados às mucosas e glândulas exócrinas. A sIgA possui uma estrutura capaz de resisti r à degradação proteolíti ca de enzimas bacterianas e digesti vas, o que a torna ideal para proteção do trato gastrointesti nal. Na mucosa bucal a sIgA representa a mais importante barreira imunológica, impedindo a aderência e a penetração de microorganismos, sendo uti lizada como parâmetro do status imunológico dessa mucosa. Objeti vo: Realizar uma revisão de literatura a respeito da imunoglobulina A secretora liberada na saliva, enfocando sua formação, secreção e as principais funções imunológicas na proteção da mucosa bucal. Conclusão: A imunoglobulina A secretora possui óti mas característi cas para a proteção da mucosa bucal, atribuídas à sua estrutura e ação específi ca e inespecífi ca. Os resultados de estudos clínico/laboratoriais associados a sua grande quanti dade salivar, sugerem uma parti cipação relevante da sIgA nos processos eti ológicos e fi siopatológicos de lesões na mucosa bucal, evidenciando a necessidade de uma maior atenção às funções dessa imunoglobulina em estudos posteriores.Introducti on: Mucosa surfaces are in direct contact with the external environment, being exposed to a great variety of anti gens. These surfaces have relati ve vulnerability and the secreti on of anti bodies by the mucosal immune system is the main defense mechanism, maintaining unknown and/ or potenti ally pathogenic anti gens out of the organism. Among these anti bodies, the most abundant is a polymeric IgA, denominated secretory immunoglobulin A (sIgA), which is produced by plasmocytes associated with mucosas and exocrine glandules. A sIgA has a structure capable of resisti ng to the proteolyti c degradati on of bacterial and digesti ve enzymes, which makes it ideal for protecti ng the gastrointesti nal tract. In the oral mucosa, sIgA represents the most important immunological barrier, impeding the adherence and penetrati on of microorganisms and being used as a parameter of immunological status of the mucosa. Objecti ve: This paper presents a literature review on the sIgA released in the saliva, focusing on its formati on, secreti on and the main immunological functi ons on the protecti on of the oral mucosa. Conclusion: sIgA has excellent characteristi cs for protecti ng the oral mucosa, which are att ributed to its structure and specifi c and unspecifi c acti ons. The results of clinical/laboratorial...

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Selective IgA Deficiency and Autoimmunity

Cited by 111 publications

References 61 publications

Allergic and autoimmune disorders in families with selective IgA deficiency

Allergic and autoimmune disorders in families with selective IgA deficiency

Autoimmunity in human primary immunodeficiency diseases

O Papel da Imunoglobulina A Secretora no Mecanismo de Defesa da Mucosa Bucal

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