Selective IgA Deficiency and Coeliac Disease

Collin, Pekka; Mäki, Markku; Keyriläinen, O; Hällström, O; Reunala, Timo; Pasternack, Amos

doi:10.3109/00365529209000089

Cited by 193 publications

(113 citation statements)

References 16 publications

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“…A prevalência da DC em pacientes com DM1 encontrada foi semelhante à relatada em pesquisas anteriores (1,4,16 Em função do custo maior do exame ATGT e da associação da DC com a imunodeficiência de IgA (18), o anticorpo antigliadina apresenta-se como uma boa opção para a triagem da DC.…”

Section: Discussionunclassified

Estudo da prevalência da doença celíaca em crianças e adolescentes com diabetes melito tipo 1: resultado de 10 anos de acompanhamento

Gonçalves

Silva

Tanure

et al. 2013

Arq Bras Endocrinol Metab

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OBJETIVO: Avaliar a prevalência da doença celíaca (DC) em crianças e adolescentes com diabetes melito tipo 1 (DM1) atendidos no Serviço de Endocrinologia Pediátrica do Hospital das Clínicas da Universidade Federal de Minas Gerais. SUJEITOS E MÉTODOS: Incluídos no estudo crianças e adolescentes com diagnóstico prévio de DM1 acompanhadas no serviço no período de março de 1999 a abril de 2009, com idades entre zero e 18 anos. Todos foram rastreados para DC na primeira consulta e anualmente. A investigação foi realizada por meio da dosagem dos anticorpos da classe IgA (AGAA) e IgG (AGAG) antigliadina. Os pacientes com AGAA e/ou AGAG acima de duas vezes o valor de referência foram submetidos à biópsia intestinal. RESULTADOS: Foram excluídos 21 pacientes do total inicial de 384. Destes, 50 tiveram a sorologia positiva e 29 foram submetidos à biópsia intestinal. A prevalência encontrada foi de 3,1%. CONCLUSÃO: O rastreamento periódico da DC nos pacientes diabéticos deve ser encorajado, dada sua alta prevalência.

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Section: Discussionunclassified

Estudo da prevalência da doença celíaca em crianças e adolescentes com diabetes melito tipo 1: resultado de 10 anos de acompanhamento

Gonçalves

Silva

Tanure

et al. 2013

Arq Bras Endocrinol Metab

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“…In CD, about 10% to 12% of the patients can exhibit IgA deficiency (16) . This is the reason why total serologic levels of this immunoglobulin are determined to avoid false-negative results in EmA IgA (8,20) .…”

Section: Introductionmentioning

confidence: 99%

Antiendomysium antibodies in brazilian patients with celiac disease and their first-degree relatives

Utiyama

et al. 2001

Arq. Gastroenterol.

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“…Although it has been well established that CD is triggered by peptides from the wheat protein gliadin (19), the factors that predispose individuals to CD and their role in disease induction are less clearly understood. It is conceivable that a deficiency in intestinal IgA leads to insufficient exclusion of food Ag, including gluten, since selective IgA deficiency predisposes individuals to CD at a rate 10 -20 times that of the general population (15,16). The regulation of Ag uptake by epithelial cells (in the absence of epithelial damage) could be critical to the induction of oral tolerance, such that tolerance to gliadin may not be initially established in IgAdeficient individuals.…”

mentioning

confidence: 99%

Role of the Polymeric Ig Receptor in Mucosal B Cell Homeostasis

Uren

Johansen

Wijburg

et al. 2003

The Journal of Immunology

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Secretory IgA (SIgA) is the most characteristic component of the mucosal immune system and has long been considered the major protective factor that prevents pathogens from invading hosts through the mucosae. Recent studies, however, have suggested that complete immunity against a range of mucosal bacterial and viral pathogens can be achieved in the absence of IgA. Therefore, to further dissect the role of SIgA, we generated mice deficient in the polymeric Ig receptor (pIgR−/− mice). As a result of an inability to transport dimeric IgA to the secretions, pIgR−/− mice are deficient in SIgA and accumulate circulating dimeric IgA, with serum levels 100-fold greater than those observed in normal mice. Examination of lamina propria mononuclear cells showed that pIgR−/− mice had ∼3 times as many IgA-secreting cells as C57BL/6 mice. Further analysis showed that these cells displayed the differentiated IgA+ B220− phenotype and accounted for a 2-fold increase in the number of lamina propria blast cells in the pIgR−/− mice. Subsequent experiments showed that OVA-specific CD4+ T cell expansion following OVA feeding was not elevated in pIgR−/− mice. Furthermore, no differences in CD8+ T cell tolerance or induction of influenza virus-specific CD8+ T cells were detected in pIgR−/− mice compared with controls. Therefore, while SIgA is clearly involved in maintaining some parameters of mucosal homeostasis in the intestine, the mechanisms associated with its barrier function and the clinical consequences of its deficiency are yet to be identified.

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Selective IgA Deficiency and Coeliac Disease

Cited by 193 publications

References 16 publications

Estudo da prevalência da doença celíaca em crianças e adolescentes com diabetes melito tipo 1: resultado de 10 anos de acompanhamento

Estudo da prevalência da doença celíaca em crianças e adolescentes com diabetes melito tipo 1: resultado de 10 anos de acompanhamento

Antiendomysium antibodies in brazilian patients with celiac disease and their first-degree relatives

Role of the Polymeric Ig Receptor in Mucosal B Cell Homeostasis

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