Selective localization of bone marrow-derived ramified cells in the brain adjacent to the attachments of choroid plexus

Hasegawa-Ishii, Sanae; Shimada, Atsuyoshi; Inaba, Muneo; Li, Ming; Shi, Ming; Kawamura, Noriko; Takei, Shiro; Chiba, Yoichi; Hosokawa, Masanori; Ikehara, Susumu

doi:10.1016/j.bbi.2012.12.010

Cited by 25 publications

(40 citation statements)

References 72 publications

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“…The inner stroma of the choroid plexus is richly irrigated by fenestrated capillaries (Wolburg and Paulus, 2010), allowing the free passage of circulating molecules and immune cells, into this compartment. Under healthy conditions, however, the blood-CSF barrier (BCSFB) formed by the choroid plexus epithelial cells restricts immune-cell entry into the CSF and the brain parenchyma (Baruch and Schwartz, 2013; Engelhardt et al, 2001; Hasegawa-Ishii et al, 2013). AD patients exhibit major alterations in choroid plexus structure and morphology, as well as in epithelial cell function, attributable mainly to the increase in toxic Aβ peptides (Brkic et al, 2015; Johanson et al, 2004; Vargas et al, 2010).…”

Section: Choroid Plexus In Admentioning

confidence: 99%

Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer’s Disease?

Louveau

Mesquita

Kipnis

2016

Neuron

147

119

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Summary Lymphatic vasculature drains interstitial fluids, which contain the tissue’s waste products and ensures immune surveillance of the tissues, allowing immune-cell recirculation. Until recently the central nervous system (CNS) was considered to be devoid of a conventional lymphatic vasculature. The recent discovery in the meninges of a lymphatic network that drains the CNS calls into question classic models for the drainage of macromolecules and immune cells from the CNS. In the context of neurological disorders, the presence of a lymphatic system draining the CNS potentially offers a new player and a new avenue for therapy. In this review, we will attempt to integrate the known primary functions of the tissue lymphatic vasculature that exists in peripheral organs with the proposed function of meningeal lymphatic vessels in neurological disorders, specifically multiple sclerosis and Alzheimer’s disease. We propose that these (and potentially other) neurological afflictions can be viewed as diseases with neuro-lympho-vascular component and should be therapeutically targeted as such.

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Section: Choroid Plexus In Admentioning

confidence: 99%

Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer’s Disease?

Louveau

Mesquita

Kipnis

2016

Neuron

147

119

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“…(29), we used bone marrow-chimeric mice prepared by the IBM procedure to investigate the distribution and time-dependent changes in the density of bone marrow-derived cells as well as in their differentiation in the brain under non-inflammatory conditions (29). Bone marrow-derived cells start to appear in the leptomeninges and choroid plexus stroma at 2 weeks after BMT, and to appear in the brain perivascular spaces at 4 weeks after BMT in the bone marrow chimera.…”

Section: Sites Of Intercellular Interaction Between Brain Cells and Imentioning

confidence: 99%

“…A group of brain regions that has not been a focus of attention from scientists in the field is a group of particular brain parenchymal regions that is populated by bone marrow-derived cells (29). These regions are relatively small in size and discrete.…”

Section: Sites Of Intercellular Interaction Between Brain Cells and Imentioning

confidence: 99%

Histological Architecture Underlying Brain–Immune Cell–Cell Interactions and the Cerebral Response to Systemic Inflammation

Shimada

Hasegawa-Ishii

2017

Front. Immunol.

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Although the brain is now known to actively interact with the immune system under non-inflammatory conditions, the site of cell–cell interactions between brain parenchymal cells and immune cells has been an open question until recently. Studies by our and other groups have indicated that brain structures such as the leptomeninges, choroid plexus stroma and epithelium, attachments of choroid plexus, vascular endothelial cells, cells of the perivascular space, circumventricular organs, and astrocytic endfeet construct the histological architecture that provides a location for intercellular interactions between bone marrow-derived myeloid lineage cells and brain parenchymal cells under non-inflammatory conditions. This architecture also functions as the interface between the brain and the immune system, through which systemic inflammation-induced molecular events can be relayed to the brain parenchyma at early stages of systemic inflammation during which the blood–brain barrier is relatively preserved. Although brain microglia are well known to be activated by systemic inflammation, the mechanism by which systemic inflammatory challenge and microglial activation are connected has not been well documented. Perturbed brain–immune interaction underlies a wide variety of neurological and psychiatric disorders including ischemic brain injury, status epilepticus, repeated social defeat, and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Proinflammatory status associated with cytokine imbalance is involved in autism spectrum disorders, schizophrenia, and depression. In this article, we propose a mechanism connecting systemic inflammation, brain–immune interface cells, and brain parenchymal cells and discuss the relevance of basic studies of the mechanism to neurological disorders with a special emphasis on sepsis-associated encephalopathy and preterm brain injury.

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“…Another report examined the finding that IBM-BMT facilitates the entry of transplanted BM cells into the brain parenchyma. IBM-BMT may thus prove beneficial in the experimental treatment of psychiatric and neurological diseases [82]. …”

Section: Intra-bone Marrow-bone Marrow Transplantation (Ibm-bmt) Amentioning

confidence: 99%

Stem Cell Treatment for Alzheimer’s Disease

Guo

Ikehara

2014

IJMS

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Alzheimer’s disease (AD) is a progressive and neurodegenerative disorder that induces dementia in older people. It was first reported in 1907 by Alois Alzheimer, who characterized the disease as causing memory loss and cognitive impairment. Pathologic characteristics of AD are β-amyloid plaques, neurofibrillary tangles and neurodegeneration. Current therapies only target the relief of symptoms using various drugs, and do not cure the disease. Recently, stem cell therapy has been shown to be a potential approach to various diseases, including neurodegenerative disorders, and in this review, we focus on stem cell therapies for AD.

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Selective localization of bone marrow-derived ramified cells in the brain adjacent to the attachments of choroid plexus

Cited by 25 publications

References 72 publications

Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer’s Disease?

Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer’s Disease?

Histological Architecture Underlying Brain–Immune Cell–Cell Interactions and the Cerebral Response to Systemic Inflammation

Stem Cell Treatment for Alzheimer’s Disease

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