Selective non-ablative wrinkle reduction by laser

Bjerring, Peter; Clement, Marc; Heickendorff, Lene; Egevist, Henrik; Kiernan, Michael

doi:10.1080/14628830050516542

Cited by 206 publications

(145 citation statements)

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“…There is also direct stimulation of fibroblasts by laser energy to produce more collagen. Bjerring et al 5 suggested that inflammatory mediators released from vascular endothelial cells damaged by the laser might cause new dermal collagen production by fibroblasts. There is also some nonspecific thermal damage from the scattering effect from both lasers that was seen in several biopsy specimens taken during the present evaluation.…”

Section: Commentmentioning

confidence: 99%

Combination 532-nm and 1064-nm Lasers for Noninvasive Skin Rejuvenation and Toning

Lee¹

2003

Arch Dermatol

129

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Background: Noninvasive techniques for skin rejuvenation are quickly becoming standard in the treatment of mild rhytids and overall skin toning. Multiple laser wavelengths and modalities have been used with varying degrees of success, including 532-nm, 585-nm, 1064nm, 1320-nm, 1450-nm, and 1540-nm wavelengths. Objectives: To evaluate a combination technique using a long-pulsed, 532-nm potassium titanyl phosphate (KTP) laser and a long-pulsed 1064-nm Nd:YAG laser, separately and combined, for noninvasive photorejuvenation and skin toning and collagen enhancement and to establish efficacy and degree of success.Design: Prospective nonrandomized study with longitudinal follow-up.Setting: Private dermatologic surgery and laser practice.Methods: A total of 150 patients, with skin types I through V, were treated with long-pulsed KTP 532-nm and long-pulsed Nd:YAG 1064-nm lasers, separately and combined. For the KTP 532-nm laser, the fluences varied between 7 to 15 J/cm 2 at 7-to 20-millisecond pulse durations with a 2-mm handpiece and 6 to 15 J/cm 2 at 30-to 50-millisecond pulses with a 4-mm handpiece. The 1064-nm Nd:YAG laser fluences were set at 24 to 30 J/cm 2 for a 10-mm handpiece. These energies were delivered at 30-to 65-millisecond pulse durations. All subjects were treated at least 3 times and at most 6 times, depending on patient satisfaction level, at monthly intervals and were observed for up to 18 months after the last treatment.Main Outcome Measures: All patients were asked to fill out a "severity scale" on which redness, pigmentation, rhytids, skin tone/tightness, texture, and patient satisfaction were noted before and after each treatment. Redness, pigmentation, rhytids, skin tone/tightness, and texture were also evaluated by the physician and another observer.Results: After 3 to 6 treatments, 50 patients treated with the 532-nm KTP laser alone showed improvement of 70% to 80% in redness and pigmentation, 30% to 50% in skin tone/tightening, 30% to 40% in skin texture, and 20% to 30% in rhytids. Another 50 patients treated with the 1064-nm Nd:YAG laser alone showed improvement of 10% to 20% in redness, 0% to 10% in pigmentation, 10% to 30% in skin tone/tightening, 20% to 30% in skin texture, and 10% to 30% in rhytids. The third group of 50 patients treated with both KTP and Nd:YAG lasers showed improvement of 70% to 80% in redness and pigmentation, 40% to 60% in skin tone/tightening, 40% to 60% in skin texture, and 30% to 40% in rhytids. Skin biopsy specimens taken at 1-, 2-, 3-, and 6-month intervals demonstrated new collagen formation. Conclusions:All 150 patients exhibited mild to moderate improvement in the appearance of rhytids, moderate improvement in skin toning and texture, and great improvement in the reduction of redness and pigmentation. The KTP laser used alone produced results superior to those of the Nd:YAG laser. Results from combination treatment with both KTP and Nd:YAG lasers were slightly superior to those achieved with either laser alone.

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Section: Commentmentioning

confidence: 99%

Combination 532-nm and 1064-nm Lasers for Noninvasive Skin Rejuvenation and Toning

Lee¹

2003

Arch Dermatol

129

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“…[5][6][7][8][9] Thus, over time, one can see a remodeling of the photodamaged skin to give an improved histological and clinical result. 5,9 Heat can also have specific effects on collagen, the most abundant protein in the dermis. Studies indicate that collagen fibrils, when heated to the correct temperature over a period of time, will contract, which may lead to the rise in tissue tightening due to the breakage of the intramolecular hydrogen bonds.…”

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confidence: 99%

Histological and Ultrastructural Evaluation of the Effects of a Radiofrequency-Based Nonablative Dermal Remodeling Device

et al. 2004

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“…[6][7][8][9][10][11][12][13][14][15][16] Treatment regimens ranged from a single procedure 6 to 8 treatments at 2-to 3-week intervals. 11 In 10 of the trials, the clinical end point consisted of observation only.…”

Section: Resultsmentioning

confidence: 99%

Clinical Efficacy of Devices for Nonablative Photorejuvenation

Leffell¹

2002

Arch Dermatol

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Selective non-ablative wrinkle reduction by laser

Abstract: In conclusion, the treatment modality described may be a new approach to the treatment of wrinkles.

Cited by 206 publications

References 13 publications

Combination 532-nm and 1064-nm Lasers for Noninvasive Skin Rejuvenation and Toning

Combination 532-nm and 1064-nm Lasers for Noninvasive Skin Rejuvenation and Toning

Histological and Ultrastructural Evaluation of the Effects of a Radiofrequency-Based Nonablative Dermal Remodeling Device

Clinical Efficacy of Devices for Nonablative Photorejuvenation

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