Selective packaged circular RNAs in milk extracellular vesicles during <i>Staphylococcus aureus</i> infection may have potential against bacterial infection

Ma, Shaoyang; Niu, Mingze; Hao, Zehua; Liu, Miaomiao; Tong, Chao; Zhao, Xin

doi:10.1080/15476286.2020.1853975

Cited by 13 publications

(7 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LncRNAs in human milk-derived EVs also perform functions related to growth in children and the development of diseases, including allergic diseases, asthma, obesity, and autoimmune diseases (Karlsson et al, 2016). Moreover, circRNAs exist in exosomes derived from bovine Ma et al, 2021) and porcine milk (Zeng et al, 2020). A total of 2059 distinct circRNAs from bovine milk-derived exosomes were identified via highthroughput RNA sequencing .…”

Section: Components Of Evs In Breast Milkmentioning

confidence: 99%

Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant

Jiang

You

Zhang

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Extracellular vesicles (EVs) are released by all cells under pathological and physiological conditions. EVs harbor various biomolecules, including protein, lipid, non-coding RNA, messenger RNA, and DNA. In 2007, mRNA and microRNA (miRNA) carried by EVs were found to have regulatory functions in recipient cells. The biological function of EVs has since then increasingly drawn interest. Breast milk, as the most important nutritional source for infants, contains EVs in large quantities. An increasing number of studies have provided the basis for the hypothesis associated with information transmission between mothers and infants via breast milk-derived EVs. Most studies on milk-derived EVs currently focus on miRNAs. Milk-derived EVs contain diverse miRNAs, which remain stable both in vivo and in vitro; as such, they can be absorbed across different species. Further studies have confirmed that miRNAs derived from milk-derived EVs can resist the acidic environment and enzymatic hydrolysis of the digestive tract; moreover, they can be absorbed by intestinal cells in infants to perform physiological functions. miRNAs derived from milk EVs have been reported in the maturation of immune cells, regulation of immune response, formation of neuronal synapses, and development of metabolic diseases such as obesity and diabetes. This article reviews current status and advances in milk-derived EVs, including their history, biogenesis, molecular contents, and biological functions. The effects of milk-derived EVs on growth and development in both infants and adults were emphasized. Finally, the potential application and future challenges of milk-derived EVs were discussed, providing comprehensive understanding and new insight into milk-derived EVs.

show abstract

Section: Components Of Evs In Breast Milkmentioning

confidence: 99%

Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant

Jiang

You

Zhang

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…Demonstrated the selective circRNA packaging mechanism regulated by the infection. [ 197 ] Cow Microarray mRNA profiles are altered by viral load and lactate dehydrogenase concentration. [ 187 ] Cow qPCR, NGS Total of 276 miRNAs identified with 9 differentially expressed between forage-fed and non-forage fibre source-fed cows.…”

Section: Milk-derived Evsmentioning

confidence: 99%

Ruminant Milk-Derived Extracellular Vesicles: A Nutritional and Therapeutic Opportunity?

et al. 2021

View full text Add to dashboard Cite

Milk has been shown to contain a specific fraction of extracellular particles that are reported to resist digestion and are purposefully packaged with lipids, proteins, and nucleic acids to exert specific biological effects. These findings suggest that these particles may have a role in the quality of infant nutrition, particularly in the early phase of life when many of the foundations of an infant’s potential for health and overall wellness are established. However, much of the current research focuses on human or cow milk only, and there is a knowledge gap in how milk from other species, which may be more commonly consumed in different regions, could also have these reported biological effects. Our review provides a summary of the studies into the extracellular particle fraction of milk from a wider range of ruminants and pseudo-ruminants, focusing on how this fraction is isolated and characterised, the stability and uptake of the fraction, and the reported biological effects of these fractions in a range of model systems. As the individual composition of milk from different species is known to differ, we propose that the extracellular particle fraction of milk from non-traditional and minority species may also have important and distinct biological properties that warrant further study.

show abstract

“…Later, two other miRNAs were shown to play important roles in the response to infection with Staphylococcus aureus , miR-378, and miR-185, and were found to be particularly abundant and highly differentially expressed in mastitic milk compared to normal milk [ 234 ]. A specific packaging of another type of small RNAs—the circRNAs—was highlighted by Ma et al [ 235 ] in response to bacterial infections because the presence of Staphylococcus aureus induced a different set of circRNAs in mEVs, most of which were implicated in immune functions [ 235 ]. In the case of subclinical mastitis, in which the symptoms are masked, the identification of biomarkers is crucial but more complex.…”

Section: The Theranostic Potential Of Animal Mevsmentioning

confidence: 99%

Extracellular Vesicles from Animal Milk: Great Potentialities and Critical Issues

Mecocci

Trabalza‐Marinucci

Cappelli

2022

Animals

View full text Add to dashboard Cite

Other than representing the main source of nutrition for newborn mammals, milk delivers a sophisticated signaling system from mother to child that promotes postnatal health. The bioactive components transferred through the milk intake are important for the development of the newborn immune system and include oligosaccharides, lactoferrin, lysozyme, α-La, and immunoglobulins. In the last 15 years, a pivotal role in this mother-to-child exchange has been attributed to extracellular vesicles (EVs). EVs are micro- and nanosized structures enclosed in a phospholipidic double-layer membrane that are produced by all cell types and released in the extracellular environment, reaching both close and distant cells. EVs mediate the intercellular cross-talk from the producing to the receiving cell through the transfer of molecules contained within them such as proteins, antigens, lipids, metabolites, RNAs, and DNA fragments. The complex cargo can induce a wide range of functional modulations in the recipient cell (i.e., anti-inflammatory, immunomodulating, angiogenetic, and pro-regenerative modulations) depending on the type of producing cells and the stimuli that these cells receive. EVs can be recovered from every biological fluid, including blood, urine, bronchoalveolar lavage fluid, saliva, bile, and milk, which is one of the most promising scalable vesicle sources. This review aimed to present the state-of-the-art of animal-milk-derived EV (mEV) studies due to the exponential growth of this field. A focus on the beneficial potentialities for human health and the issues of studying vesicles from milk, particularly for the analytical methodologies applied, is reported.

show abstract

Selective packaged circular RNAs in milk extracellular vesicles during Staphylococcus aureus infection may have potential against bacterial infection

Cited by 13 publications

References 54 publications

Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant

Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant

Ruminant Milk-Derived Extracellular Vesicles: A Nutritional and Therapeutic Opportunity?

Extracellular Vesicles from Animal Milk: Great Potentialities and Critical Issues

Contact Info

Product

Resources

About