Selective synthesis of double temperature-sensitive polymer–peptide conjugates

Stoica, F.; Alexander, Cameron; Tirelli, Nicola; Miller, Aline F.; Saiani, Alberto

doi:10.1039/b806782a

Cited by 31 publications

(39 citation statements)

References 33 publications

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“…The turbid gel phase persisted to 75 8C, i.e., the gel melting temperature of oligopeptide. [8] As a new mechanism for multiple phase transitions in a polymer system, here we report a poly(ethylene glycol)-polycaprolactone-poly(ethylene glycol) (PEG-PCL-PEG) triblock copolymer with a specific composition of EG 13 C-L 23 EG 13 . Similar to Pluronic P103, the polymer aqueous solution undergoes sol-gel (hard gel)-sol-gel (soft gel)-sol (syneresis) transitions as the temperature increases.…”

Section: S-3mentioning

confidence: 99%

Multiple Sol‐Gel Transitions of PEG‐PCL‐PEG Triblock Copolymer Aqueous Solution

Hwang

Joo²,

Choi³

et al. 2010

Macromol. Rapid Commun.

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An aqueous solution of a poly(ethylene glycol)-polycaprolactone-poly(ethylene glycol) (PEG-PCL-PEG) with a composition of EG(13) CL(23) EG(13) undergoes multiple transitions, from sol-to-gel (hard gel)-to-sol-to-gel (soft gel)-to-sol, in the concentration range 20.0∼35.0 wt.-%. Through dynamic mechanical analysis, UV-vis spectrophotometry, small angle X-ray scattering, differential scanning calorimetry, microcalorimetry and (13) C NMR spectroscopy, the mechanism of these transitions was investigated. The hard gel and soft gel are distinguished by the crystalline and amorphous state of the PCL. The extent of PEG dehydration and the molecular motion of each block also played a critical role in the multiple transitions. This paper suggests a new mechanism for these multiple transitions driven by temperature changes.

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Section: S-3mentioning

confidence: 99%

Multiple Sol‐Gel Transitions of PEG‐PCL‐PEG Triblock Copolymer Aqueous Solution

Hwang

Joo²,

Choi³

et al. 2010

Macromol. Rapid Commun.

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“…The use of stimuli‐responsive polymers in hydrogels allows their application in drug delivery, biosensing, and tissue engineering . Among the stimuli‐responsive polymers, poly( N ‐isopropylacrylamide) (PNIPAAm) is the most popular due to its water solubility, as well as its lower critical solution temperature (LCST) at 37 °C in aqueous solution …”

Section: Self‐assembling Hydrogels Of Peptide–polymer Conjugatesmentioning

confidence: 99%

Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications

Radvar

Azevedo

2018

Macromolecular Bioscience

127

107

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Peptides and polymers are the "elite" building blocks in hydrogel fabrication where the typical approach consists of coupling specific peptide sequences (cell adhesive and/or enzymatically cleavable) to polymer chains aiming to obtain controlled cell responses (adhesion, migration, differentiation). However, the use of polymers and peptides as structural components for fabricating supramolecular hydrogels is less well established. Here, the literature on the design of peptide/polymer systems for self-assembly into hybrid hydrogels, as either peptide-polymer conjugates or combining both components individually, is reviewed. The properties (stiffness, mesh structure, responsiveness, and biocompatibility) of the hydrogels are then discussed from the viewpoint of their potential biomedical applications.

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“…For example, dual-temperature sensitive peptide polymers have been synthesized by Stoica [102] that utilize N-isopropylacrylamide-co-acrylamide (NIPAAM) conjugated to an octapeptide ‘FEFEFKFK’. The ‘FEK16’ motif forms a hydrogel at room temperature (Table 2).…”

Section: Mechanisms Of Peptide-mediated Tumor Targetingmentioning

confidence: 99%

Environmentally responsive peptides as anticancer drug carriers☆

Aluri

Janib

MacKay

2009

Advanced Drug Delivery Reviews

104

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The tumor microenvironment provides multiple cues that may be exploited to improve the efficacy of established chemotherapeutics; furthermore, polypeptides are uniquely situated to capitalize on these signals. Peptides provide: 1) a rich repertoire of biologically specific interactions to draw upon; 2) environmentally-responsive phase behaviors, which may be tuned to respond to signatures of disease; 3) opportunities to direct self-assembly; 4) control over routes of biodegradation; 5) the option to seamlessly combine functionalities into a single polymer via a one-step biosynthesis. As development of cancer-targeted nanocarriers expands, peptides provide a unique source of functional units that may target disease. This review explores potential microenvironmental physiology indicative of tumors and peptides that have demonstrated an ability to target and deliver to these signals.

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Selective synthesis of double temperature-sensitive polymer–peptide conjugates

Abstract: A novel synthetic route has been developed to couple selectively a modified octa-peptide, that is able to gel at low temperature, to the prototypical thermoresponsive polymer poly(N-isopropylacrylamide) to give a bioconjugate that exhibits double thermoresponsiveness.

Cited by 31 publications

References 33 publications

Multiple Sol‐Gel Transitions of PEG‐PCL‐PEG Triblock Copolymer Aqueous Solution

Multiple Sol‐Gel Transitions of PEG‐PCL‐PEG Triblock Copolymer Aqueous Solution

Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications

Environmentally responsive peptides as anticancer drug carriers☆

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