Selectively hydrogenated soybean oil with conjugated linoleic acid modifies body composition and plasma lipids in rats

Choi, Na-Young; Kwon, Dae-Hyeon; Yun, Suk Hoo; Jung, Mun Yhung; Shin, Hyun‐Kyung

doi:10.1016/j.jnutbio.2003.12.002

Cited by 22 publications

(17 citation statements)

References 31 publications

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“…In particular, the epididymal fat showed a more significant decrease than the visceral fat ( table 3 ). These results support a recent report showing that the retroperitoneal depot was most sensitive to CLA [26] . As the level of body fat decreased, the TG levels in the plasma and liver showed a larger decrease in the BTC and FOC groups than in the BT and FO groups ( table 5 ).…”

Section: The Effects Of Cla On the Body Weight And Fat Depositionsupporting

confidence: 92%

Conjugated Linoleic Acid Reduces Adipose Depots without Reduction of Stearoyl Coenzyme A Desaturase 1 Gene Expression

Hwang

Kang²

2007

Ann Nutr Metab

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Aims and Methods: This study investigated the effects of conjugated linoleic acid (CLA) on the body weight, fat deposition and the expression of stearoyl coenzyme A desaturase 1 (SCD1) in the livers of male ICR mice that were fed with either beef tallow (BT) or fish oil (FO) supplemented with CLA. Mice weighing 25–30 g were divided into four groups, BT and BT supplemented with 0.5% CLA (BTC), FO and FO supplemented with 0.5% CLA (FOC). Each group consisted of 8 mice, and they were fed the experimental diets for 4 weeks. The experimental diets were composed of 59.18% carbohydrates, 19.73% proteins and 21.09% fat in terms of their contributions to total calories, and other nutrients were identical. CLA was added to the diets of the CLA supplementation groups at 0.5% (w/w). The measurement of triglyceride (TG) was done by using a kit. Fatty acid compositions were analyzed in both the plasma and the liver using a gas chromatograph. The levels of SCD1 expression were analyzed by RT-PCR in the liver. Results: No significant difference was found in the levels of food intake, body weight and food efficiency among experimental groups. However, the levels of both epididymal and visceral fat weight were significantly lower in the CLA-supplemented groups, BTC and FOC (p < 0.05). The level of the triglyceride concentration was also significantly lower in the CLA-supplemented groups (p < 0.05). The levels of the liver SCD1 gene expression were also higher in the CLA-supplemented groups. However, significant inhibition of conversion from C16:0 to C16:1 was found in both fatty acid compositions of the liver (p < 0.05). Conclusion: Addition of 0.5% CLA did not inhibit the liver SCD1 gene expression; however, it showed decreasing effects on the fat pad weight, the concentration of TG and on fatty acid composition, leading to a decrease in the fat depositions. Such effects were clearer when CLA was supplemented to BT rather than FO.

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Section: The Effects Of Cla On the Body Weight And Fat Depositionsupporting

confidence: 92%

Conjugated Linoleic Acid Reduces Adipose Depots without Reduction of Stearoyl Coenzyme A Desaturase 1 Gene Expression

Hwang

Kang²

2007

Ann Nutr Metab

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“…However, the same group recently reported that coconut oil-fed mice replenished with EFA did not show any significant difference in fat mass when compared to mice fed coconut oil alone, suggesting that effects of CLA may be independent of EFAD [48]. A study in SD rats for 6 weeks evaluated the effects of hydrogenated soyabean oil (SBO) containing high levels of CLA (21%) and found that inguinal, epididymal and retroperitoneal adipose depots were significantly decreased with CLA supplementation [49]. Although CLA content of SBO was high, level of t10c12 CLA was considerably low in the diet formulation.…”

Section: Animal Studiesmentioning

confidence: 99%

Biological effects of conjugated linoleic acids in health and disease

Bhattacharya

Banu

Rahman

et al. 2006

The Journal of Nutritional Biochemistry

571

429

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“…These CLA effects are associated with the conjugated double bound system and are very often due to the separate action of the most studied isomers, cis-9,trans-11 and trans-10,cis-12. Thus, trans-10,cis-12 is the CLA isomer which induces a very marked body fat reduction (4,5).…”

mentioning

confidence: 99%

A comparison between CLNA and CLA effects on body fat, serum parameters and liver composition

Miranda

Fernández‐Quintela

Macarulla

et al. 2009

J. Physiol. Biochem.

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The potential of conjugated linoleic acid (CLA) as an anti-obesity molecule for humans is still a matter for debate. Thus, a great deal of scientific work is focussed on the research of new effective molecules without deleterious effects on health. The aim of the present work was to analyse the effects of jacaranda seed oil, rich in a conjugated linolenic acid (CLNA), jacaric acid (cis-8,trans-10,cis-12), on body fat, serum parameters and liver composition in rats, and to compare these effects with those of trans-10,cis-12 CLA. Twenty-six male Wistar rats were divided into three groups fed with high-fat diets, supplemented or not (control group) with 0.5% trans-10,cis-12 CLA (CLA group) or 0.5% jacaric acid (CLNA group) for 7 weeks. No statistical differences in food intake or in final body weight were found. Whereas CLA reduced adipose tissue size, CLNA did not. Both CLA and CLNA significantly reduced non-HDL-cholesterol. In spite of a lack of significant changes in glucose and insulin levels, HOMA-IR index was significantly increased, as well as did non-esterified fatty acid levels in CLNA-fed rats. No changes in liver composition were observed. In conclusion, under our experimental conditions, jacaric acid, unlike CLA, does not show a body-fat lowering effect. Even though it leads to a healthy lipoprotein profile, it impairs insulin function. Consequently, it cannot be proposed as an anti-obesity molecule.

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Selectively hydrogenated soybean oil with conjugated linoleic acid modifies body composition and plasma lipids in rats

Cited by 22 publications

References 31 publications

Conjugated Linoleic Acid Reduces Adipose Depots without Reduction of Stearoyl Coenzyme A Desaturase 1 Gene Expression

Conjugated Linoleic Acid Reduces Adipose Depots without Reduction of Stearoyl Coenzyme A Desaturase 1 Gene Expression

Biological effects of conjugated linoleic acids in health and disease

A comparison between CLNA and CLA effects on body fat, serum parameters and liver composition

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