Selectivity of a bromelain based enzymatic debridement agent: A porcine study

Rosenberg, Lior; Krieger, Yuval; Silberstein, Eldad; Arnon, Ofer; Sinelnikov, Igor; Bogdanov-Berezovsky, Alex; Singer, Adam J.

doi:10.1016/j.burns.2012.02.011

Cited by 60 publications

(23 citation statements)

References 7 publications

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“…Its activity varies greatly with different preparations [67]. In two different enzymatic debridement studies carried out in porcine model, using different bromelain-based agents, namely, Debriding Gel Dressing (DGD) and Debrase Gel Dressing showed rapid removal of the necrotic layer of the dermis with preservation of the unburned tissues [68, 69]. In another study on Chinese landrace pigs, enzymatic debridement using topical bromelain in incised wound tracks accelerated the recovery of blood perfusion, pO 2 in wound tissue, controlled the expression of TNF- α , and raised the expression of TGT- β [70].…”

Section: Medicinal Usesmentioning

confidence: 99%

Properties and Therapeutic Application of Bromelain: A Review

Pavan

Jain

Shraddha

et al. 2012

Biotechnology Research International

379

279

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Bromelain belongs to a group of protein digesting enzymes obtained commercially from the fruit or stem of pineapple. Fruit bromelain and stem bromelainare prepared differently and they contain different enzymatic composition. “Bromelain” refers usually to the “stem bromelain.” Bromelain is a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors. In vitro and in vivo studies demonstrate that bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain is considerably absorbable in the body without losing its proteolytic activity and without producing any major side effects. Bromelain accounts for many therapeutic benefits like the treatment of angina pectoris, bronchitis, sinusitis, surgical trauma, and thrombophlebitis, debridement of wounds, and enhanced absorption of drugs, particularly antibiotics. It also relieves osteoarthritis, diarrhea, and various cardiovascular disorders. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death. This paper reviews the important properties and therapeutic applications of bromelain, along with the possible mode of action.

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Section: Medicinal Usesmentioning

confidence: 99%

Properties and Therapeutic Application of Bromelain: A Review

Pavan

Jain

Shraddha

et al. 2012

Biotechnology Research International

379

279

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“…2). Some of its reported actions include inhibition of platelet aggregation, anti-edema (MacKay et al 2003), antithrombotic and fibrinolytic activity (Errasti et al 2016), anti-inflammatory action (Brien et al 2004), anti-tumor action (Dhandayuthapani et al 2012;Pillai et al 2013), modulation of cytokines and immunity, skin debridement properties Rosenberg et al 2012), enhanced absorption of other drugs (Orsini 2006), mucolytic properties, digestive assistance, enhanced wound healing ), cardiovascular and circulatory improvement (Kavitha et al 2013). Some of its therapeutic applications are briefly discussed below.…”

Section: Applications Of Bromelainmentioning

confidence: 99%

“…It selectively acts upon the effected tissues without harming the normal ones . Bomelain simplifies the debridement process and offers improved and accelerated healing and quick reepithelialization (Singer et al 2010a;Hu et al 2011;Rosenberg et al 2012).Researchers have found bromelain to be useful in healing post-surgical wounds and aid to lessen their aching and swelling etc (Graf 2000;MacKayand Miller2003).…”

Section: Burns Debriding Agentmentioning

confidence: 99%

Bromelain: Methods of Extraction, Purification and Therapeutic Applications

Manzoor

Nawaz

Mukhtar

et al. 2016

Braz. arch. biol. technol.

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“…Bromelain has been known for its clinical and therapeutic applications, particularly for modulation of tumor growth, selective burn debridement, improvement of antibiotic action, and anti‐inflammatory, antithrombotic, and fibrinolytic activities . Recently, it has been shown to modulate the cellular responses of lymphocyte after oral use .…”

Section: Introductionmentioning

confidence: 99%

Polymer‐based alternative method to extract bromelain from pineapple peel waste

Novaes

Santos-Ebinuma

Mazzola

et al. 2013

Biotech and App Biochem

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Bromelain is a mixture of proteolytic enzymes present in all tissues of the pineapple (Ananas comosus Merr.), and it is known for its clinical therapeutic applications, food processing, and as a dietary supplement. The use of pineapple waste for bromelain extraction is interesting from both an environmental and a commercial point of view, because the protease has relevant clinical potential. We aimed to study the optimization of bromelain extraction from pineapple waste, using the aqueous two-phase system formed by polyethylene glycol (PEG) and poly(acrylic acid). In this work, bromelain partitioned preferentially to the top/PEG-rich phase and, in the best condition, achieved a yield of 335.27% with a purification factor of 25.78. The statistical analysis showed that all variables analyzed were significant to the process.

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Selectivity of a bromelain based enzymatic debridement agent: A porcine study

Cited by 60 publications

References 7 publications

Properties and Therapeutic Application of Bromelain: A Review

Properties and Therapeutic Application of Bromelain: A Review

Bromelain: Methods of Extraction, Purification and Therapeutic Applications

Polymer‐based alternative method to extract bromelain from pineapple peel waste

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