Selenitetriglycerides—Redox-active agents

Flis, Anna; Suchocki, Piotr; Królikowska, Monika Anna; Suchocka, Zofia; Remiszewska, Małgorzata; Lidia, Śliwka; Ksiazek, Iza; Sitarz, Karolina; Sochacka, Małgorzata; Hoser, Grazyna; Anuszewska, Elżbieta; Wroczyński, Piotr; Jastrzębski, Zenon

doi:10.1016/j.pharep.2014.07.017

Cited by 15 publications

(15 citation statements)

References 23 publications

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“…Selenium is known to modify and regulate redox processes depending on the needs of an organism. The selenium in the selenium-enriched L. edodes mycelium exhibited a therapeutic effect; therefore, we can say that it is safe for use, despite its low therapeutic index [28,29]. https://doi.org/10.1371/journal.pone.0233456.g001…”

Section: Discussionmentioning

confidence: 95%

Preliminary study on Se-enriched Lentinula edodes mycelium as a proposal of new feed additive in selenium deficiency

et al. 2020

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The presence of selenium in European soil is low and this causes its deficiency in livestock and, in consequence, in humans. This study aimed to obtain Lentinula (L.) edodes mycelium with the maximum content of selenium. This species was used for experiment based on its documented medicinal properties. Calves were fed with selenium-enriched L. edodes mycelium, and serum selenium concentration, average daily weight gains and selected immune parameters were estimated. The selenium-enriched mushroom was found to be safe based on cytotoxicity tests (MTT and LDH tests) and for this reason it was used for further experiments. The mean quantity of selenium in the serum of calves fed with selenium-enriched L. edodes mycelium was significantly higher than that of control calves. Additionally, the calves fed with selenium-enriched L. edodes mycelium had higher body weight gains than those of control calves. White blood cell counts and subpopulations of lymphocytes in the experimental and control calves were within the reference range. The administration of L. edodes enriched with selenium had a beneficial effect on state of health of the calves.

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Section: Discussionmentioning

confidence: 95%

Preliminary study on Se-enriched Lentinula edodes mycelium as a proposal of new feed additive in selenium deficiency

et al. 2020

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“…Selenium and vitamin E are the most studied antioxidants for reducing the risk of PCa by modifying the intracellular redox state, as previously described in LNCaP cell lines treated with selenium ( 65 ). The Selenium and Vitamin E Cancer Prevention Trial is one of the largest and most important studies in the chemoprevention of PCa to date.…”

Section: Evidence Synthesismentioning

confidence: 99%

Oxidative stress and prostatic diseases

Roumeguère

Sfeir

Rassy

et al. 2017

Molecular and Clinical Oncology

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Prostatic diseases are a common health problem among males in Western countries, and include chronic prostatic diseases, which have an unclear pathogenesis and few treatment options. In vitro and in vivo studies describe oxidative stress as a major pathway involved in the occurrence of benign prostatic hyperplasia, prostatic cancer and chronic prostatitis. Thus, the oxidative stress cascade is a potential target for the treatment of prostatic diseases. This paper presents a systematic review of the available data concerning the association between oxidative stress and the most common chronic prostatic diseases, and describes the available treatment options that act upon this pathway.

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“…SelP binds heparin in a pH-dependent manner, which suggests its attraction to inflammation sites [ 33 ]. The primary source of plasma SelP is the liver, from where SelP is transported to peripheral tissues, including brain [ 54 , 55 ]. Its role in the CNS is unique, because brain tissue can take up tracer Se in a form of SelP and is unable to take up directly radioactive molecule 75 Se [ 52 ].…”

Section: Selenium and Selenoproteins In Normal Brain Functionmentioning

confidence: 99%

Selenium in the Therapy of Neurological Diseases. Where is it Going?

Dominiak¹,

Wilkaniec

Wroczyński³

et al. 2016

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Selenium (34Se), an antioxidant trace element, is an important regulator of brain function. These beneficial properties that Se possesses are attributed to its ability to be incorporated into selenoproteins as an amino acid. Several selenoproteins are expressed in the brain, in which some of them, e.g. glutathione peroxidases (GPxs), thioredoxin reductases (TrxRs) or selenoprotein P (SelP), are strongly involved in antioxidant defence and in maintaining intercellular reducing conditions. Since increased oxidative stress has been implicated in neurological disorders, including Parkinson’s disease, Alzheimer’s disease, stroke, epilepsy and others, a growing body of evidence suggests that Se depletion followed by decreased activity of Se-dependent enzymes may be important factors connected with those pathologies. Undoubtedly, the remarkable progress that has been made in understanding the biological function of Se in the brain has opened up new potential possibilities for the treatment of neurological diseases by using Se as a potential drug. However, further research in the search for optimal Se donors is necessary in order to achieve an effective and safe therapeutic income.

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Selenitetriglycerides—Redox-active agents

Cited by 15 publications

References 23 publications

Preliminary study on Se-enriched Lentinula edodes mycelium as a proposal of new feed additive in selenium deficiency

Preliminary study on Se-enriched Lentinula edodes mycelium as a proposal of new feed additive in selenium deficiency

Oxidative stress and prostatic diseases

Selenium in the Therapy of Neurological Diseases. Where is it Going?

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