Selenium analogues of ( S )-clopidogrel: preparation method and properties

The cyclization of arylalkynes under selenobromination conditions, combined with an acid-induced 3,2-aryl shift, was elaborated as a general synthetic pathway for the preparation of polyhydroxy-2- and -3-arylbenzo[b]selenophenes from the same starting materials. The redox properties, free-radical-scavenging ability, and cytotoxicity against malignant cell lines (MCF-7, MDA-MB-231, HepG2, and 4T1) of the synthesized compounds were explored, and the obtained results were used to consider the structure-activity relationships (SARs) in these compounds. Consequently, the structural features that were responsible for the highly potent peroxyl-radical-scavenging activity were established.

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Natural‐Antioxidant‐Inspired Benzo[b]selenophenes: Synthesis, Redox Properties, and Antiproliferative Activity

Paegle

Домрачева

Turovska

et al. 2016

Chemistry An Asian Journal

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ChemInform Abstract: Selenium Analogues of (S)‐Clopidogrel: Preparation Method and Properties.

2016

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Selenium analogs of raloxifene: antioxidant activity endowed to an old drug

Домрачева

Gulbe

Paegle

et al. 2016

Chem Heterocycl Comp

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Selenium analogues of ( S )-clopidogrel: preparation method and properties

Cited by 15 publications

References 39 publications

Natural‐Antioxidant‐Inspired Benzo[b]selenophenes: Synthesis, Redox Properties, and Antiproliferative Activity

Natural‐Antioxidant‐Inspired Benzo[b]selenophenes: Synthesis, Redox Properties, and Antiproliferative Activity

ChemInform Abstract: Selenium Analogues of (S)‐Clopidogrel: Preparation Method and Properties.

Selenium analogs of raloxifene: antioxidant activity endowed to an old drug

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