2012
DOI: 10.1016/j.urology.2011.12.006
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Selenium and Lycopene Attenuate Cisplatin-induced Testicular Toxicity Associated With Oxidative Stress in Wistar Rats

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Cited by 72 publications
(49 citation statements)
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“…Similar conclusions were drawn by Tamiselvan et al [18], Türk et al [49] and Salem et al [51] reporting that LYC administration resulted in a normalization of the antioxidant status together with a stabilization of SOD, CAT, GPx and GSH followed by a decrease of H 2 O 2 production and MDA synthesis in male reproductive cells and tissues.…”
Section: Discussionsupporting
confidence: 88%
“…Similar conclusions were drawn by Tamiselvan et al [18], Türk et al [49] and Salem et al [51] reporting that LYC administration resulted in a normalization of the antioxidant status together with a stabilization of SOD, CAT, GPx and GSH followed by a decrease of H 2 O 2 production and MDA synthesis in male reproductive cells and tissues.…”
Section: Discussionsupporting
confidence: 88%
“…Although BPA did not change the body weights and relative organ weights, it exerted various subtle influences on the body. In the present study, we found oxidative stress was induced by the exposure in terms of the significant reduction of SOD and GSH‐Px, and the abnormal accumulation of MDA in both serum and testicular tissues (Salem et al, ). Oxidative stress as a mediator in apoptosis and autophagy has been well identified, and the important role of mitochondria in the processes is also widely accepted (Slater et al, ; Lee et al, ).…”
Section: Discussionsupporting
confidence: 55%
“…In the present study, a significant decrease in body and reproductive organs weights accompanied by marked histopathological alterations in the testicular tissue was observed in cisplatin treated rats, findings that are in agreement with previous work (Azu et al, 2010;Salem et al, 2012;Adejuwon et al, 2015). The reduction in reproductive organs weight is due to marked parenchymal atrophy in germinal cell layers, loss of maturation in the germinal cells and arrested spermatocytes at different stages of division which lead to tubular shrinkage in testicular tissues (Ilbey et al, 2009a; Beytur et al, 2012).…”
Section: Discussionsupporting
confidence: 94%