Selenium and Oxidant Injury in Patients with Cystic Fibrosis

Elevated plasma levels of F2α isoprostane in cystic fibrosis

“…This is despite mean plasma levels of vitamins A and E within the laboratory normal range and a clinic policy of multivitamin supplementation, with vitamins A and E supplements for patients known to have low-plasma vitamin A and/or E. This finding is consistent with other reports (2,(5)(6)(7)(8)(9) and confirms that lipid peroxidation is increased in CF using a reliable in vivo marker of oxidative stress. The 8-iso-PGF 2α levels for the 12 subjects with CF ≥ 14 yr of age were elevated when compared with the controls (P = 0.038).…”

Selenium Deficiency as a Cause of Overload of Iron and Unbalanced Distribution of Other Minerals

“…10,11) Changes less remarkable than our results have been reported in patients with a variety of disorders, in which somewhat low plasma concentrations of Se have been associated with higher plasma concentrations of zinc and iron and a lower concentration of copper compared with healthy controls. [17][18][19] Therefore it is possible to note that Se is not an exceptional element in the generally-held recognition that the use and metabolism of mineral nutrients are closely interrelated with each other.…”

Minerals and Trace Elements in Cystic Fibrosis

“…In plasma and RBC (Neve, et al, 1983a) 20 7-19 In plasma and RBC (Neve, et al, 1983b) 14 2-19 In plasma (Richard, et al, 1990) 13 6-15 In plasma (van Caillie-Bertrand, et al, 1982) 20 19-34 In serum (Stead, et al, 1985) 31 3-35 In serum (Michalke, 2004) 15 0-14 − (Ward, et al, 1984) No difference 27 7-20 In plasma (Portal, et al, 1993) Decreased GPX levels 14 2-19 In plasma and RBC (Richard, et al, 1990) 6 − Very low levels in untreated children (Foucaud, et al, 1988) 20 − Mild deficiency in children with pancreatic enzyme replacement (Foucaud, et al, 1988) 15 0-14 Significant decrease in children below the age of 6 (Ward, et al, 1984) No difference 13 10-22 − (Percival, et al, 1995) Se levels in other analytes − 1-18 Decreased Se levels in hair of CF patient from Stavropol region, Russia (Dworkin, et al, 1987) Zinc (Zn)…”

“…Decreased levels 40 1-46 In plasma of 10% of CF patients (Akanli, et al, 2003) 15 Mean 1.8 months In plasma of 30% of CF patients (Krebs, et al, 2000) 27 3 months-12 years In 96% of North Indian CF children (Yadav, et al, 2014) 304 18-66 In plasma of 22% of patients with moderate lung disease (Damphousse, et al, 2014) 13 2-19 In plasma (Safai-Kutti, et al, 1991) 20 7-19 In plasma of patients with moderate-severe growth retardation and severe pulmonary disease (Neve, et al, 1983b) 14 2-19 In serum (Richard, et al, 1990) 51 1-46 In RBC of 31% of CF patients (Akanli, et al, 2003) Elevated levels 20 7-19 In RBC (Neve, et al, 1983a) 20 7-19 In RBC (Neve, et al, 1983b) No difference 18 6-17 In plasma, decreases with age (Jacob, et al, 1978) 20 7-19 In plasma of relatively healthy CF patients (Neve, et al, 1983b) 15…”

“…No difference in Cu levels in submandibular saliva (Blomfield, et al, 1973) 13 6-15 Elevated Cu levels in urine (van Caillie-Bertrand, et al, 1982) 16 0-20 Decreased Cu levels in pancreas (Kopito, Shwachman, 1976) Iron (Fe) Decreased levels 27 3 months-12 years In 48% of North Indian CF children (Yadav, et al, 2014) 14 2-19 − (Richard, et al, 1990) 18 6-18 In plasma (Solomons, et al, 1981) 15…”