Selenium and silver nanoparticles: A new approach for treatment of bacterial and viral hepatic infections via modulating oxidative stress and DNA fragmentation

Gad, Sameh S.; Abdelrahim, Dina S.; Ismail, Sameh H.; Ibrahim, Sherine M.

doi:10.1002/jbt.22972

Cited by 9 publications

(15 citation statements)

References 26 publications

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“…AgNPL significantly alleviated the effect of LPS on pro-inflammatory cytokines such as TNF-α and the pro-inflammatory mediator NO, compared with AgNps; however, for the pro-inflammatory cytokine IL-6, both the AgNPL and AgNps had the same significant lessening effect. These findings aligned with [ 27 ]. The difference in inflammatory mediator levels can be attributed to the different AgNP particle size used in our work.…”

Section: Discussionsupporting

confidence: 91%

“…In our study, AgNP of two sizes were employed in the treatment in this study: a small particle size (10 and 75 nm) and big particle size (250–300 nm) were included in the treatment of LPS-contaminated liver slices, along with silymarin [ 27 ]. The biochemical results confirmed the anti-inflammatory effects of AgNP on both sizes, yet the results verified that the anti-inflammatory effects of AgNP were size-dependent.…”

Section: Discussionmentioning

confidence: 99%

“…One simple explanation is that most researchers pool numerous slices to collect enough protein, which requires many slices, yet it is mandatory if a time-course experiment or different conditions are being performed [ 26 ]. A number of previous studies were carried out with the same time of exposure as well as conditions [ 27 , 28 ]. Liver slices are the best in vitro method for showing the hepatotoxicity effect of the AgNP [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…Our study aimed to investigate and compare the potential protective role of the AgNP using two different particle sizes and to assess the potential risk. AgNP of two sizes were employed in the treatment in this study: a small particle size (10 and 75 nm) and big particle size (250–300 nm) were included in the treatment of LPS liver slices, along with silymarin [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Hepatoprotective Effect of Silver Nanoparticles at Two Different Particle Sizes: Comparative Study with and without Silymarin

Elfaky

Sirwi

Ismail

et al. 2022

CIMB

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Silver nanoparticles have been used for numerous therapeutic purposes because of their increased biodegradability and bioavailability, yet their toxicity remains questionable as they are known to interact easily with biological systems because of their small size. This study aimed to investigate and compare the effect of silver nanoparticles’ particle size in terms of their potential hazard, as well as their potential protective effect in an LPS-induced hepatotoxicity model. Liver slices were obtained from Sprague Dawley adult male rats, and the thickness of the slices was optimized to 150 μm. Under regulated physiological circumstances, freshly cut liver slices were divided into six different groups; GP1: normal, GP2: LPS (control), GP3: LPS + AgNpL (positive control), GP4: LPS + silymarin (standard treatment), GP5: LPS + AgNpS + silymarin (treatment I), GP6: LPS + AgNpL + silymarin (treatment II). After 24 h of incubation, the plates were gently removed, and the supernatant and tissue homogenate were all collected and then subjected to the following biochemical parameters: Cox2, NO, IL-6, and TNF-α. The LPS elicited marked hepatic tissue injury manifested by elevated cytokines and proinflammatory markers. Both small silver nanoparticles and large silver nanoparticles efficiently attenuated LPS hepatotoxicity, mainly via preserving the cytokines’ level and diminishing the inflammatory pathways. In conclusion, large silver nanoparticles exhibited effective hepatoprotective capabilities over small silver nanoparticles.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hepatoprotective Effect of Silver Nanoparticles at Two Different Particle Sizes: Comparative Study with and without Silymarin

Elfaky

Sirwi

Ismail

et al. 2022

CIMB

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“…In recent years, the non-metals, such as selenium, have acquired greater interest from the medical and scientific community for their antiviral activity using nanoparticles or selenium coated surfaces [ 19 , 20 ]. Due to their unique physical and chemical properties, nanoparticles have been the subject of extensive research over the past few decades.…”

Section: Introductionmentioning

confidence: 99%

The Potential Antiviral Effects of Selenium Nanoparticles and Coated Surfaces

2022

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Modern epidemics quickly spread across borders and continents with devastating effects on both human health and the world economy. This issue is made worse by the various ways that infections are spread, including through aerosol, droplets, and fomites. The antibacterial qualities of various surface materials and coatings have been the subject of much research. However, the antiviral activity of metal coatings can be heavily influenced by imbalances in metal distribution and the presence of other metal impurities. As such, there is interest in developing novel surface coatings that can reduce the transmission of active viral particles in healthcare facilities. In recent years, the non-metals, such as selenium and nanoparticles, have acquired greater interest from the medical and scientific community for their antiviral surface activity. In this review, we will discuss the cellular and physiological functions of selenium in mammalian cells and against viral infections. We then discuss the mechanism behind selenium coated surfaces and their efficacy against bacterial infections. Lastly, we examine the antiviral activity of selenium, and the potential antiviral activity of selenium nanoparticles and coatings.

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Emerging alternatives to traditional anthelmintics: the in vitro antiparasitic activity of silver and selenium nanoparticles, and pomegranate (Punica granatum) peel extract against Haemonchus contortus

Kaiaty,

Salib,

El-Gameel

et al. 2023

Trop Anim Health Prod

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Haemonchus contortus (H. contortus) is one of the most prevalent gastrointestinal nematodes, causing health problems and economic losses in ruminants. Nanotechnology holds great promise as a field of science, with potential applications in veterinary medicine. This study investigated the in vitro anthelmintic activity of silver nanoparticles (AgNPs), selenium nanoparticles (SeNPs), and pomegranate peel extract (Punica granatum; PPE) on different stages of H. contortus: eggs, larvae, and adults. The in vitro anthelmintic efficacy was evaluated using the egg hatching inhibition assay (EHA), the third larval stage paralysis assay (LPA), and the adult worm motility inhibition assay (WMI). Six dilutions of PPE were utilized for EHA, LPA, and WMI, ranging from 0.25 to 6 mg/ml. AgNPs dilutions ranged from 0.00001 to 1.0 μg/ml for EHA and LPA and 1 to 25 μg/ml for WMI. SeNPs were utilized at dilutions of 1, 5, 10, and 15 μg/ml for EHA, LPA, and WMI. The results showed that the lowest concentration of AgNPs, SeNPs, and PPE significantly inhibited egg hatching. To further assess larvicidal activity, AgNPs at the highest concentration of 1 μg/ml induced a strong larvicidal effect, as did SeNPs at the lowest concentration. On the contrary, PPE displayed a significant larvicidal effect at 1 mg/ml compared to the control. The percentage mortality of adult H. contortus was measured as follows (mortality (%) = the number of dead adult H. contortus/total number of adult H. contortus per test × 100). The death of the adult H. contortus was determined by the absence of motility. Adult H. contortus mortality percentage was also significantly affected by all three agents when compared to the control. The AgNPs, SeNPs, and PPE have effective antiparasitic activity on gastrointestinal parasitic nematodes. These results provide evidence of the excellent antiparasitic properties of AgNPs, SeNPs, and PPE, demonstrating their effectiveness in controlling eggs, larvae, and adult H. contortus in vitro.

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Selenium and silver nanoparticles: A new approach for treatment of bacterial and viral hepatic infections via modulating oxidative stress and DNA fragmentation

Cited by 9 publications

References 26 publications

Hepatoprotective Effect of Silver Nanoparticles at Two Different Particle Sizes: Comparative Study with and without Silymarin

Hepatoprotective Effect of Silver Nanoparticles at Two Different Particle Sizes: Comparative Study with and without Silymarin

The Potential Antiviral Effects of Selenium Nanoparticles and Coated Surfaces

Emerging alternatives to traditional anthelmintics: the in vitro antiparasitic activity of silver and selenium nanoparticles, and pomegranate (Punica granatum) peel extract against Haemonchus contortus

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