Selenium and thyroid cancer: a systematic review

Maia, Mônica de Oliveira; Batista, Bruna Aparecida Melo; Sousa, Morgana Pinheiro; Souza, Luana Matos de; Maia, Carla Soraya Costa

doi:10.1080/01635581.2019.1679194

Cited by 18 publications

(18 citation statements)

References 47 publications

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“…Although geography and detection methods may affect experimental results. 23 Although most studies support a decrease in serum selenium levels in patients with thyroid cancer, and supplementation with selenium may reduce the risk of certain diseases, the decline is not specific, except for thyroid cancer, including infections, many diseases, including Parkinson's, can cause selenium levels to decline. 24 The significance of vitamin D in the diagnosis and prognosis of thyroid cancer is also conflicted, although in 2016 and 2017, Choi 25 and Danilovic 26 denied serum 25 (OH) D 3 's role in determining the risk of thyroid cancer in their studies respectively.…”

Section: Markers Related To Thyroid Functionmentioning

confidence: 99%

<p>The Blood Biomarkers of Thyroid Cancer</p>

Wang¹,

Chang²,

Jia³

et al. 2020

CMAR

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Introduction: With the gradual increase in the incidence of thyroid cancer, people's attention to thyroid cancer has also gradually increased. Although the prognosis of thyroid cancer is rather mild compared to other cancers, it will still bring a heavy psychological burden on people who have been diagnosed. At present, the diagnosis of thyroid cancer mainly depends on ultrasound and percutaneous fine needle aspiration (pFNA). Due to the unsatisfactory accuracy of the diagnosis methods we use now, there are still some thyroid nodules that cannot be clearly diagnosed before surgery. Methods: In this article, we have searched for relevant research on blood markers of thyroid cancer in the past five years and categoried them into four groups. Discussion: Though we have not found a biomarker which can diagnose thyroid cancer both sensitively and specifically, we do found many substances that are related to it, and have the potential to recognize it and help the diagnosis. And perhaps combined models can do it better.

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Section: Markers Related To Thyroid Functionmentioning

confidence: 99%

<p>The Blood Biomarkers of Thyroid Cancer</p>

Wang¹,

Chang²,

Jia³

et al. 2020

CMAR

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“…Therefore, a fluctuation in its level could affect the expression of antioxidant selenoproteins, sensitive to the intake of Se in the thyroid (GPx1 and GPx3). In the review by Olivera et al, studies corroborate the reduction in the activity of selenoproteins in thyroid cancer, in case of Se deficiency [95].…”

Section: Selenium and Thyroid Cancermentioning

confidence: 83%

“…Thyroid cancer is the most common endocrine tumor, responsible for more than half a million new cases per year, ranking 9th place in cancers prevalence worldwide [92,93]. It remains rare in children and adolescent, the median age of diagnostic is 45 to 50 years old [94], it is diagnosed three times more often in women than in men [95]. Thyroid cancer includes three main types of tumors: medullary thyroid carcinoma, anaplastic thyroid carcinoma and differentiated thyroid carcinoma [96].…”

Section: Selenium and Thyroid Cancermentioning

confidence: 99%

“…Differentiated carcinoma alone accounts for about 90% of thyroid cancers. It is derived from the follicular cells of the thyroid, which are responsible for the production of thyroid hormones [95].…”

Section: Selenium and Thyroid Cancermentioning

confidence: 99%

“…In Table 2, we highlight that most studies indicate low Se levels in the patients with thyroid cancer. Se deficiency in various diseases, including cancer, could be related to a high level of free radicals caused by oxidative stress [95]. Significant increase in production of ROS is observed in thyroid tumor tissue samples vs. healthy tissue [81,103].…”

Section: Selenium and Thyroid Cancermentioning

confidence: 99%

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Selenium Deficiency—From Soil to Thyroid Cancer

et al. 2020

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Selenium (Se) is an essential micronutrient present in human diet, entering in the composition of selenoproteins as selenocysteine (Se-Cys) amino acid. At the thyroid level, these proteins play an important role as antioxidant and in hormone metabolism. Selenoproteins are essential for the balance of redox homeostasis and antioxidant defense of mammalian organisms, while the corresponding imbalance is now recognized as the cause of many diseases including cancer. The food chain is the main source of Se in human body. Dietary intake is strongly correlated with Se content in soil and varies according to several factors such as geology and atmospheric input. Both Se deficiency and toxicity have been associated with adverse health effects. This review synthesizes recent data on the transfer of Se from soil to humans, Se U-shaped deficiency and toxicity uptake effects and particularly the impact of Se deficiency on thyroid cancer.

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Impact of Essential and Toxic Trace Metals on Thyroid Health and Cancer: A Review

Stojsavljević

Rovčanin

2021

Expo Health

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Most investigations conducted in the last four decades have shown a rising incidence of thyroid diseases worldwide. Although our knowledge of the molecular pathways of thyroid disease has advanced, the initial steps in thyroid cancerogenesis have not yet been sufficiently elucidated. However, recent human biomonitoring studies have shown that specific trace metals, as major endocrine disrupters, could be considered as risk factors for impaired thyroid health and the evolution of thyroid cancer (TC). In this review, the impact of essential and toxic trace metals from the environment on thyroid health and TC was evaluated. Furthermore, this review clarifies which trace metals most likely contribute to the etiology of TC. Biomarkers based on trace metal ratios are proposed. Overall, the information described in this review is expected to be useful in planning future fundamental and applied studies on the endocrine toxicity of essential and toxic trace metals.

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Selenium and thyroid cancer: a systematic review

Cited by 18 publications

References 47 publications

<p>The Blood Biomarkers of Thyroid Cancer</p>

<p>The Blood Biomarkers of Thyroid Cancer</p>

Selenium Deficiency—From Soil to Thyroid Cancer

Impact of Essential and Toxic Trace Metals on Thyroid Health and Cancer: A Review

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