Selenium and vitamin E supplementation reduces oxidative stress and increases antioxidant enzyme activity in a mice model of psoriasis

Yin, MeiShang; Guo, Dongmei; Yin, LongLong; Kang, An; Zhang, Yi; Chen, Xi

doi:10.5414/tex01305

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…Its efficacy in the reduction of plasma MDA level is also noted in Iranian patients developing GDM (18) and in patients suffering from renal failure after their supplementation (200 mg/day Se for three months) (29). The collected data from research work carried out on animal models expressed that Se supplementation induced a significant decrease in hepatic MDA level in mice with psoriasis (30), and cerebral MDA level in male rats subjected to intense physical activity (31).…”

Section: Discussionmentioning

confidence: 99%

Influence of selenium supplementation on carbohydrate metabolism and oxidative stress in pregnant women with gestational diabetes mellitus

Saifi¹,

Mabrouk²,

Saifi³

et al. 2019

Journal of Medical Biochemistry

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Summary Background In the presence of conflicting advice about the relationship between selenium-type II diabetes-oxidative stress trio, this study aimed to assess the consequences of selenium supplementation on fasting plasma glucose (FPG) level, antioxidant activities of selenodependent and non-selenodependent enzymes, and other markers of oxidative stress studied for the first time during gestational diabetes mellitus (GDM). Methods This research was carried out among 180 pregnant Algerian women, 60 of whom were in good health, 60 women with GDM did not take supplements, and 60 women with GDM took selenium orally (50 μg/d) for 12 weeks starting from their second trimester of pregnancy. Blood samples were taken in order to assay FPG level and oxidative stress markers. Results Selenium supplementation during GDM has demonstrated its hypoglycemic power in the significant decline of FPG level, and its antioxidant properties in the significant reinforcement of antioxidant activities of erythrocyte selenodependent enzymes (glutathione peroxidase and glutathione reductase), the significant increase in erythrocyte catalase and superoxide dismutase activities simultaneously with the highest decrease in erythrocyte and plasma malondialdehyde levels. This decrease was only significant for plasma carbonyl proteins, which was not the case for erythrocyte carbonyl proteins. Conclusions The recourse to selenium supplementation by seleno-deficient pregnant women with GDM is beneficial for maternal health. This micronutrient exploits its antioxidant and insulin-mimetic properties in the maintenance of blood glucose homeostasis and the fight against oxidative stress, and consequently, its supplementation delays the occurrence of GDM complications.

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Section: Discussionmentioning

confidence: 99%

Influence of selenium supplementation on carbohydrate metabolism and oxidative stress in pregnant women with gestational diabetes mellitus

Saifi¹,

Mabrouk²,

Saifi³

et al. 2019

Journal of Medical Biochemistry

View full text Add to dashboard Cite

show abstract

Selenium and vitamin E supplementation reduces oxidative stress and increases antioxidant enzyme activity in a mice model of psoriasis

Abstract: Key words selenium (Se) -vitamin E (VE) -methotrexate (MTX) -psoriasis -

Cited by 1 publication

References 19 publications

Influence of selenium supplementation on carbohydrate metabolism and oxidative stress in pregnant women with gestational diabetes mellitus

Influence of selenium supplementation on carbohydrate metabolism and oxidative stress in pregnant women with gestational diabetes mellitus

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