Selenium-binding protein 1 as a tumor suppressor and a prognostic indicator of clinical outcome

Abstract

Selenium is a trace element that plays a critical role in physiological processes and cancer prevention, whose functions may be through its effects on selenium-containing proteins. Selenium-binding protein 1 (SBP1) is a member of an unusual class of selenium-containing proteins that may function as a tumor suppressor in multiple cancer types and whose levels have been shown to be lower in cancers as compared to corresponding normal tissues. This review is intended to summarize recent advances in gaining an understanding of the significance of SBP1 in carcinogenesis, and suggest that SBP1 could be developed as a potential biomarker for cancer progression and prognosis.

Reduction of selenium-binding protein 1 sensitizes cancer cells to selenite via elevating extracellular glutathione: A novel mechanism of cancer-specific cytotoxicity of selenite

“…Furthermore, our in vitro and in vivo studies have also shown that increasing SBP1 expression in colorectal cancer cells attenuates cancer cell migration and tumor growth in nude mice [42]. Consistent with these findings, knockdown of SBP1 by small interfering RNA (siRNA) in the nontransformed human liver cells results in a substantial increase in cell proliferation index and migration capacity [27], suggesting that SBP1 acts as a tumor suppressor [43], which is further supported by the recent study that SBP1 negatively regulates HIF-1α expression and suppresses the malignant phenotype of prostate cancer cells [44].…”

Sodium Selenite Inhibits Proliferation of Gastric Cancer Cells by Inducing SBP1 Expression

“…Compared with normal tissue, downregulation of SBP1 expression has been observed in several cancer types, such as gastric carcinoma, prostate, colon and ovarian cancer (Xia et al 2011;Giusti et al 2012;Yang and Diamond 2013). Previous data showed that SBP1 suppression promoted gastric cancer cell proliferation and cell migration, while SBP1 overexpression was associated with anti-cancer activities (Zhang et al 2013).…”

“…Recently, SBP1 was identified as a tumor suppressor and a prognostic indicator of clinical outcome (Yang and Diamond 2013). To understand the role of SBP1 in the inhibitory effect of selenium on gastric cancer cells, we measured the change of SBP1 expression in SGC7901 and N87 cells treated with 30 μM sodium selenite for 48 h. The results showed that sodium selenite elevated the expression level of SBP1 in both SGC7901 and N87 cells (Fig.…”

“…Selenium-binding protein, which binds selenium by mechanisms that are currently unclear, is a selenium-containing protein found in mammals. The human selenium-binding protein 1 (SBP1, SELENBP1 or hSP56) gene is located at chromosome position 1q21-22 and is the homologue of the mouse SP56 gene (Yang and Diamond 2013). SBP1 has been shown to bind selenium covalently and has been found to be the possible mediator of selenium's anticancer functions (Porat et al 2000;Silvers et al 2010;Huang et al 2012).…”

Plasma Selenium Level based on Dietary Intake in Geriatric Clinic Population at Dr. Hasan Sadikin General Hospital Bandung

“…Based on Yang et al, selenium has three forms of protein categories, which are protein containing selenomethionine, protein containing selenocysteine, and peptide which bounded selenium such SELENBP1. 10 The assessment of selenium level in this study was done only by measuring SELENBP1 instead of measuring the total plasma of selenium level.…”