Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis

Stewart, Marjory S; Spallholz, Julian E.; Neldner, Kenneth H.; Pence, Barbara C.

doi:10.1016/s0891-5849(98)00147-6

Cited by 266 publications

(159 citation statements)

References 21 publications

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“…Our results concerning the relation between selenium and apoptosis in humans were contrary to results from several laboratory studies, suggesting that selenium increased anticancer apoptotic activity (34)(35)(36)(37)(38)(39)(40)(41)(42). There are several reasons that our results may differ from laboratory studies.…”

Section: Discussioncontrasting

confidence: 99%

“…The possibility that selenium may increase anticancer apoptotic activity has been suggested by several carcinogenesis studies (34)(35)(36)(37)(38)(39)(40)(41)(42). It is unclear how selenium might induce apoptosis; however, several selenium metabolites, such as hydrogen selenide, methylselenol, and selenodiglutathione, are being researched (43)(44)(45).…”

Section: Introductionmentioning

confidence: 99%

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Selenium, Apoptosis, and Colorectal Adenomas

Connelly-Frost¹,

Poole²,

Satia

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Selenium is an essential trace element found in cereals, wheat, dairy products, meat, and fish. This micronutrient may prevent carcinogenesis through several biochemical pathways; one suggested pathway is enhanced apoptosis. Objectives: The relation between selenium and colorectal adenomas was evaluated because the colorectal adenoma is the established precursor lesion of most colorectal cancers. Apoptosis was a pathway of interest because decreased apoptosis has been associated with an increased prevalence of adenomas. Our objectives were as follows: to investigate the association between (a) selenium and colorectal adenomas and (b) selenium and apoptosis.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selenium, Apoptosis, and Colorectal Adenomas

Connelly-Frost¹,

Poole²,

Satia

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The possible explanation for the slightly inhibitory effect of Se on peroxidises in P. ostreatus HAI 494 could lie in oxidative stress, which is induced by higher concentrations (Stewart et al 1999;Catal et al 2008). The stimulatory effect of Se on activity against phenol red oxidation in the absence of the external Mn 2+ , demonstrated in P. eryngii (Stajić and Vukojević 2011), was not proven in the studied species.…”

Section: Effect Of Trace Elements On the Activity Of Mn-oxidizing Permentioning

confidence: 75%

Influence of Trace Elements on Ligninolytic Enzyme Activity of Pleurotus ostreatus and P. pulmonarius

et al. 2013

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Trace elements, at tolerable concentrations, are either part of the active site or act as an activity modulator of ligninolytic enzymes of white-rot mushrooms. They are usually in plant raw materials in a non-toxic amount or non-available and extractable forms. This study evaluated the effects of Fe, Zn, and Se on the activity of laccase and Mn-oxidizing peroxidases of P. ostreatus and P. pulmonarius during solid-state fermentation of grapevine sawdust. The studied species showed different levels of tolerance to the trace elements. A stimulatory effect of the microelements on laccase activity was demonstrated in P. ostreatus, while Fe and Zn were strong inhibitors of the activity of P. pulmonarius, which was contrary to Se, independent of the cultivation period. With the exception of SeO 2 , activity of Mn-oxidizing peroxidases in P. ostreatus was suppressed in various levels by the elements. However, in P. pulmonarius, activity against phenol red oxidation in the presence of external Mn 2+ was stimulated by the elements on day 7, while on day 10, activity inhibition by Fe and Zn and stimulation by Se was noted. The effect on activity against phenol red oxidation in the absence of external Mn 2+ was the opposite.

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“…Moreover, it is well known that an excessive intake of selenium results in toxic symptoms including alkaline disease and blind staggers in livestock (8,9). Selenium poisoning is thought to result from the generation of oxygen radicals that can lead to DNA damage, lipid peroxidation, and premature protein degradation inside the cell (10)(11)(12). Selenium concentrations that prevent deficiency symptoms and are sufficient for exerting beneficial effects are close to those that lead to toxicity.…”

Section: Introductionmentioning

confidence: 99%

Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)

Jeong

2011

Mol Med Report

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Abstract. Selenium is an essential biological trace element. Adult daily intake of selenium should be approximately 100 µg per day. This compound has a two-sided effect depending on its concentration. A selenium-deficient diet is associated with various endemic diseases, including cardiomuscular malfunctions, osteoarthritis, cancer and viral infections that lead to premature death. These defects are prevented when dietary intake of selenium is adequate. The preventive biological effect of selenium is considered to be due to the antioxidant function of selenoproteins with a selenocysteine in the active site of the catalytic domain. Antioxidant selenoproteins maintain the intracellular redox status and, as a result, normal physiological processes in the cell. Conversely, an overdose of selenium generates oxygen radicals and leads to apoptotic cell death by inducing oxidation and cross-linking of protein thiol groups essential for cell survival. A lower redox state caused by selenium may be implicated in toxic diseases, such as alkali disease and blind staggers. Collectively, selenium seems to have both harmful and beneficial attributes. The aim of this review is to summarize the various biological functions of selenium and to illustrate its opposite roles as a pro-oxidant and an antioxidant.

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Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis

Cited by 266 publications

References 21 publications

Selenium, Apoptosis, and Colorectal Adenomas

Selenium, Apoptosis, and Colorectal Adenomas

Influence of Trace Elements on Ligninolytic Enzyme Activity of Pleurotus ostreatus and P. pulmonarius

Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review)

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