Selenium Deficiency in Lymphedema and Lipedema—A Retrospective Cross-Sectional Study from a Specialized Clinic

Pfister, Christina; Dawczynski, H; Schingale, Franz-Josef

doi:10.3390/nu12051211

Cited by 7 publications

(6 citation statements)

References 59 publications

(90 reference statements)

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“…A deficiency of selenium disrupts the normal functioning of immune cells, such as the disruption of protein folding and calcium flux [ 116 ]. Selenium deficiency has been observed in lipedema patients, but this deficiency was much higher in patients suffering from lymphedema, lipolymphedema (both lipedema and lymphedema), and obesity [ 118 ]. Furthermore, selenium deficiency has been suggested as a suitable marker to differentiate between lymphedema and lipedema, as lipedema did not present decreasing selenium levels with increasing stages of the disease.…”

Section: Mechanisms Implicated In the Pathogenesis Of Lipedemamentioning

confidence: 99%

Lipedema: Insights into Morphology, Pathophysiology, and Challenges

2022

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Lipedema is an adipofascial disorder that almost exclusively affects women. Lipedema leads to chronic pain, swelling, and other discomforts due to the bilateral and asymmetrical expansion of subcutaneous adipose tissue. Although various distinctive morphological characteristics, such as the hyperproliferation of fat cells, fibrosis, and inflammation, have been characterized in the progression of lipedema, the mechanisms underlying these changes have not yet been fully investigated. In addition, it is challenging to reduce the excessive fat in lipedema patients using conventional weight-loss techniques, such as lifestyle (diet and exercise) changes, bariatric surgery, and pharmacological interventions. Therefore, lipedema patients also go through additional psychosocial distress in the absence of permanent treatment. Research to understand the pathology of lipedema is still in its infancy, but promising markers derived from exosome, cytokine, lipidomic, and metabolomic profiling studies suggest a condition distinct from obesity and lymphedema. Although genetics seems to be a substantial cause of lipedema, due to the small number of patients involved in such studies, the extrapolation of data at a broader scale is challenging. With the current lack of etiology-guided treatments for lipedema, the discovery of new promising biomarkers could provide potential solutions to combat this complex disease. This review aims to address the morphological phenotype of lipedema fat, as well as its unclear pathophysiology, with a primary emphasis on excessive interstitial fluid, extracellular matrix remodeling, and lymphatic and vasculature dysfunction. The potential mechanisms, genetic implications, and proposed biomarkers for lipedema are further discussed in detail. Finally, we mention the challenges related to lipedema and emphasize the prospects of technological interventions to benefit the lipedema community in the future.

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Section: Mechanisms Implicated In the Pathogenesis Of Lipedemamentioning

confidence: 99%

Lipedema: Insights into Morphology, Pathophysiology, and Challenges

2022

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“…A study of 271 patients (including PCA) revealed that selenium deficiency was common in PCA patients and that selenium supplementation improved overall quality of life, physical and emotional functions, and fatigue. 53 Therefore, selenium supplementation may improve the prognosis of PCA patients.…”

Section: Seleniummentioning

confidence: 99%

Trace elements in pancreatic cancer

Yanjun,

Jing,

Yifei

et al. 2024

Cancer Medicine

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BackgroundPancreatic cancer (PCA) is an extremely aggressive malignant cancer with an increasing incidence and a low five‐year survival rate. The main reason for this high mortality is that most patients are diagnosed with PCA at an advanced stage, missing early treatment options and opportunities. As important nutrients of the human body, trace elements play an important role in maintaining normal physiological functions. Moreover, trace elements are closely related to many diseases, including PCA.ReviewThis review systematically summarizes the latest research progress on selenium, copper, arsenic, and manganese in PCA, elucidates their application in PCA, and provides a new reference for the prevention, diagnosis and treatment of PCA.ConclusionTrace elements such as selenium, copper, arsenic and manganese are playing an important role in the risk, pathogenesis, diagnosis and treatment of PCA. Meanwhile, they have a certain inhibitory effect on PCA, the mechanism mainly includes: promoting ferroptosis, inducing apoptosis, inhibiting metastasis, and inhibiting excessive proliferation.

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“…Weight loss before cancer diagnosis often indicates malnutrition, as side effects and metabolic changes contribute to this issue. One in three cancer patients are malnourished, with pancreatic cancer having the highest prevalence (18). For example, low selenium levels have been shown in pancreatic cancer patients (19).…”

Section: Dietary Supplementation During Pancreatic Cancermentioning

confidence: 99%

“…For example, low selenium levels have been shown in pancreatic cancer patients (19). Moreover, selenium supplementation is quite rare in those patients (18).…”

Section: Dietary Supplementation During Pancreatic Cancermentioning

confidence: 99%

Iron Citrate (Synthesit) Supplementation During Pancreas Cancer Showed Surprising Results – Case Study

Kusnir

2023

Acta Medica Martiniana

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Iron is a crucial mineral for our organism and its deficiency can cause serious health problems such as anaemia, fatigue, and impaired physical fitness. It has been shown that anaemia or iron deficiency is very common in patients with cancer. These patients benefit from iron supplementation either in intravenous or oral form. Our patient is a 67-year-old Russian woman with pancreatic cancer diagnosed in 2019. She fought off lymphocytic leukaemia in 2015. She refused treatment for her pancreatic cancer. The specific type of pancreatic cancer was not specified as the patient chose not to undergo targeted testing. Between March 2020 and February 2023, she took the dietary supplement Synthesit for three cycles (1 cycle lasted about a month). After taking the dietary supplement, a total percentage of neutrophils became in the reference range. Subjectively, the patient started to feel better after taking Synthesit and her quality of life and well-being has improved as well. It might be supposed that the dietary supplement could have some effect on her well-being and various blood parameters such as white cells count. Even though the dietary supplement is not supposed to be used for treatment of diseases, it can change some blood parameters and improve the immune system. This short case study presents the patient with pancreatic cancer who started to take the dietary supplement Synthesit which contains iron in the form of citrate salt in a dosage of 800 μg per capsule, 1 capsule per day. The dietary supplement was administered over three treatment cycles (1 cycle took about a month) from March 2020 to February 2023. It describes a difference in blood test results before taking Synthesit and after the administration of Synthesit.

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Selenium Deficiency in Lymphedema and Lipedema—A Retrospective Cross-Sectional Study from a Specialized Clinic

Cited by 7 publications

References 59 publications

Lipedema: Insights into Morphology, Pathophysiology, and Challenges

Lipedema: Insights into Morphology, Pathophysiology, and Challenges

Trace elements in pancreatic cancer

Iron Citrate (Synthesit) Supplementation During Pancreas Cancer Showed Surprising Results – Case Study

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