Selenium derivatives of L-arabinose, D-ribose, and D-xylose

Blumberg, Karl; Fuccello, Anthony; Es, Theodorus van

doi:10.1016/s0008-6215(00)83177-8

Cited by 20 publications

(9 citation statements)

References 16 publications

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“…Kimmel and Firtel.' (10) (4,5) and so the families of genes defined by their hybridization to pB41-6 represent a small fraction ofthe total mRNA species expressed duringdevelopment.…”

Section: Discussionmentioning

confidence: 99%

“…Cytoplasmic RNA was extracted from vegetative growing cells and from developing cells as described (4) except that, after the first phenol/chlorophorm extraction, the aqueous phase was extracted once with an equal volume of chloroform. Poly(A)+RNA was isolated by affinity chromatography on columns of oligo(dT)-cellulose (4 amide/3x NaCl/Cit at 370C, then twice for 30 min with 2X NaCVCit/0. 1% NaDodSO4 at 50'C, and finally twice for 30 min with 0.1 X NaCl/Cit/0.…”

Section: Methodsmentioning

confidence: 99%

“…Of the =80 predominant proteins resolved by two-dimensional gel electrophoresis whose synthesis is developmentally controlled, induction of synthesis of 40 occurs at the stage of late aggregation (2,3). Analysis of the complexity and diversity of the mRNA populations throughout development has shown that polyribosomes of late aggregating cells contain 2500 mRNA species that are absent from growing cells (4,5). Appearance of these mRNAs is regulated at the transcriptional level (6,7).…”

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confidence: 99%

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Repetitive DNA sequences cotranscribed with developmentally regulated Dictyostelium discoideum mRNAs.

Zuker¹,

Lodish²

1981

Proc. Natl. Acad. Sci. U.S.A.

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We have isolated a clone of Dictyostelium discoileum genomic DNA, pB41-6, that contains sequences that are reiterated and interspersed in the genome. The expression of these reiterated sequences is developmentally regulated, and they appear to be linked only to developmentally regulated mRNAs. We have used clone pB41-6 to isolate a set of complementary cDNA clones. Analysis of two selected clones indicates that they encode developmentally regulated mRNA species and, by means of the repetitive elements they contain, hybridize to many developmentally regulated mRNAs. In addition, we have defined two families ofmRNA species carrying these repetitive sequences: one is induced at 5.5 hr of development and the other is induced between 5.5 and 15 hr ofdevelopment. Since most ofthe mRNA species that have sequences complementary to clone pB41-6 accumulate in a coordinated fashion during development, these sequences may play an important regulatory role in the developmental program of Dictyoatelium.

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“…Kimmel and Firtel.' (10) (4,5) and so the families of genes defined by their hybridization to pB41-6 represent a small fraction ofthe total mRNA species expressed duringdevelopment.…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Repetitive DNA sequences cotranscribed with developmentally regulated Dictyostelium discoideum mRNAs.

Zuker¹,

Lodish²

1981

Proc. Natl. Acad. Sci. U.S.A.

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“…The synthesis starts with the known L-arabinose derivative 92 [112]. Protecting group manipulation of the two ends allowed the recovery of the free aldehyde from the dithioacetal.…”

Section: Iii-2-2) Intramolecular Coupling Of the A-ring And Preformedmentioning

confidence: 99%

Chemistry and Synthesis of Highly Oxygenated Alkaloids from Amaryllidaceae: Lycoricidine, Narciclasine, Pancratistatin and Analogs

Chapleur¹,

Chrétien²,

Ahmed³

et al. 2006

COS

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Plants of the genus Amaryllidaceae produce a number of alkaloids and other non-basic related molecules, some of them showing antitumor activities. The low availability of these often-complex structures, coupled with their interesting biological properties, has stimulated a long-standing interest in the chemistry community. Total syntheses of challenging structures such as lycoricidine, narciclasine and pancratistatin, which are highly oxygenated tetracyclic systems comprising up to six contiguous chiral centers on ring C, have been accomplished. These well-known structures, more than thirty years for lycoricidine, continue to stimulate interest in synthetic work to provide enough synthetic material or analogs, and also are a model target to test or develop new synthetic methodologies. The synthetic studies around these complex phenanthridinones made use of the latest up-to-date synthetic methodologies and led to the development of novel methods of functionalization and carbon-carbon bond formation. The purpose of this review is to summarize recent total syntheses and synthetic approaches towards these three highly oxygenated members of this particular class of alkaloids over the last twenty years. The review is arranged according to the different strategies used for the construction of the benzophenanthridinone ring system.

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“…[14][15][16][17] Nevertheless, efficient methods for the incorporation of selenium atoms into carbohydrate frameworks are still limited, despite the interesting synthetic and biological potential of carbohydrates containing selenium in their structures. [18][19][20][21][22] Examples already reported in the literature show that seleno-carbohydrates are effective depigmenting compounds, inhibiting melanin synthesis in melan-A cells, in similar levels to phenylthiourea, which is a well-known inhibitor of such a process. 23 In addition, selenosugars have also been detected in human urine as a metabolite for the excretion of selenium.…”

Section: Introductionmentioning

confidence: 99%