Selenium-enriched Bacillus subtilis Improves Growth Performance, Antioxidant Capacity, Immune Status, and Gut Health of Broiler Chickens

Abstract

This study aimed to investigate the effects of selenium (Se) -enriched Bacillus subtilis (Se-BS) on growth performance, antioxidant capacity, immune status and gut health in broilers. A total of 240 day-old Arbor Acres broilers were randomly allotted to four treatments of a basal diet supplemented with no Se, sodium selenite (SS), B. subtilis (BS), and Se-BS and raised for 42 days. The results showed that Se-BS supplementation signi cantly increased body weight (BW), average daily gain, the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and peroxidase (POD), total antioxidant capacity (T-AOC), interleukin (IL) -2, IL-4 and immunoglobulin (Ig) G contents in plasma, the index and wall thickness of duodenum, the villus height and crypt depth of jejunum, GPx-1 and thioredoxin reductase 1 (TR-1) mRNA levels in liver and intestine (P < 0.05), and decreased feed conversion ratio (FCR) and malondialdehyde (MDA) content in plasma (P < 0.05). Compared with the SS and BS groups, Se-BS supplementation signi cantly increased BW, the activities of GPx, CAT and POD, and the contents of IL-2, IL-4 and IgG in plasma, the index and wall thickness of duodenum, crypt depth and sIgA content of jejunum, and GPx-1 mRNA level in liver and intestine (P < 0.05), and decreased FCR and MDA content in plasma (P < 0.05). This study provides scientifc basis for further understanding Se-BS as a more effective measure to improve growth performance and healthy of broilers.

A combination of selenium and Bacillus subtilis improves the quality and flavor of meat and slaughter performance of broilers

“…Room temperature was controlled at 32-35°C for 3 days, and then gradually reduced by 3°C/week until it reached 24°C, where it was maintained for the remainder of the experiment. A previous study from our group had revealed that the average daily feed intake was similar in both groups, but the feed conversion ratio was lower for chickens fed SS, BS, and Se-BS (20).…”

Abnormal Phenylalanine Metabolism of Procapra przewalskii in Chronic Selenosis in Selenium-Enriched Habitats

“…Some studies have reported that antioxidant function is closely related to immune function, and a reduction in the antioxidant function of an organism will lead to an increase in oxygen free radicals and others. In addition, the occurrence of the lipid peroxygenation reaction will cause peroxygenation damage to the body tissue, causing cell metabolism disorders and an immunity decline [ 41 , 42 , 43 , 44 , 45 ]. In this study, the detected immune and antioxidant indices in the serum confirmed that the changing trend in antioxidant and immune functions was consistent, which was also consistent with previous studies.…”

Optimization of the Conditions for the Transformation of a Bacillus subtilis Strain L11 to Prepare Nano Selenium and Its Preliminary Application in Sheep Feed

“…The experimental results indicated that adding SeNPs rich L11 bacterial agent to feed can significantly improve the immunity of sheep. Compared with the control group, broilers supplemented with Se-rich B. subtilis not only gained weight, but also increased enzyme activities such as the GPx, CAT, POD, and plasma levels of IL-2, IL-4, and IgG, while plasma MDA levels decreased [32]. After oral administration, some B. subtilis strains can colonize the intestinal mucosa of animals, optimize the composition of intestinal microbiota, and effectively stimulate immunity and metabolism.…”