Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs

Caffeic acid supplementation ameliorates intestinal injury by modulating intestinal microbiota in LPS-challenged piglets

“…Intestinal injury is often linked to oxidative stress, as seen in weaned piglets who are exposed to various harmful stimuli that cause intestinal injury and post-weaning diarrhoea in pigs. 24 Our data indicate that a challenge with LPS increases H 2 O 2 levels and decreases T-AOC, CAT, SOD, and GSH-Px. However, CA supplementation has been shown to improve the…”

“…Intestinal injury is often linked to oxidative stress, as seen in weaned piglets who are exposed to various harmful stimuli that cause intestinal injury and post-weaning diarrhoea in pigs. 24 Our data indicate that a challenge with LPS increases H 2 O 2 levels and decreases T-AOC, CAT, SOD, and GSH-Px. However, CA supplementation has been shown to improve the levels of these antioxidant enzymes, which is in agreement with the findings of Wan et al 8 A recent study also found that CA can protect HTR-8/SVneo cells from oxidative stress and genotoxicity induced by H 2 O 2 .…”

Quercetin attenuates lipopolysaccharide-induced hepatic inflammation by modulating autophagy and necroptosis

“…TNFα and its receptor are capable of inducing necroptosis directly. Previous study indicated that the mRNA expression and protein levels of RIPK1, RIPK3, mixed lineage kinase domain-like ( MLKL ) (necroptosis indicator) increased after LPS challenge in the liver of piglets ( Wang et al, 2023 ) and chicken ( Zhirong, et al, 2021 ). One study showed that quercetin alleviated the mRNA expression and protein levels of RIPK1, RIPK3, and MLKL induced by Cadmium in the chicken brain ( Liu, et al, 2021 ).…”

Trace elements in nutrition and health: a deep dive into essentiality and mechanism of their biological roles

“…Se deficiency can lead to multiple tissue damage, such as the dysregulation of immune and redox homeostasis in broilers (Zhao et al, 2023). A novel Se source, Se-enriched Cardamine violifolia (SEC), can mitigate sepsis-induced intestinal injury, which is associated with modulating mitochondrial fusion (Wang et al, 2023).…”