Selenium is inversely associated with interleukin-6 in the elderly

Tseng, Chun-Kai; Ho, Chih-Te; Hsu, Horng‐Chaung; Lin, Chih‐Hsueh; Li, C. I.; Li, Tsai‐Chung; Liu, C. S.; Lin, Ching‐Heng; Lin, Wen‐Yuan

doi:10.1007/s12603-012-0376-6

Cited by 33 publications

(28 citation statements)

References 31 publications

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“…With regard to effects that are likely to be primarily mediated through host selenoproteins, there is considerable evidence that a dysregulated innate immune system and cytokine release have the capacity to worsen COVID-19 [ 67 , 68 , 69 ]. In the elderly, who are particularly at risk, selenium deficiency is correlated with higher circulating inflammatory cytokines [ 91 ]. Published data support the hypothesis that selenium adequacy prevents excessive cytokine activation in infectious, inflammatory and oncological models [ 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ].…”

Section: Resultsmentioning

confidence: 99%

“…In the elderly, who are particularly at risk, selenium deficiency is correlated with higher circulating inflammatory cytokines [ 91 ]. Published data support the hypothesis that selenium adequacy prevents excessive cytokine activation in infectious, inflammatory and oncological models [ 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ]. In some cases, supra-therapeutic selenium contributed to enhanced adaptive immunity by reinvigorating cytotoxic cells and moderating the release of inflammatory cytokines by the innate immune system [ 14 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

“…Selenium has been found to downregulate the IL-6 response [ 43 , 54 ] and selenium deficiency has been noted to be associated with higher levels of IL-6 in the elderly [ 91 ]. In vitro , bronchial epithelial cells infected with Influenza A grown in selenium-deficient conditions had increased IL-6 production [ 92 ].…”

Section: Introductionmentioning

confidence: 99%

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Selenium and selenoproteins in viral infection with potential relevance to COVID-19

et al. 2020

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Selenium is a trace element essential to human health largely because of its incorporation into selenoproteins that have a wide range of protective functions. Selenium has an ongoing history of reducing the incidence and severity of various viral infections; for example, a German study found selenium status to be significantly higher in serum samples from surviving than non-surviving COVID-19 patients. Furthermore, a significant, positive, linear association was found between the cure rate of Chinese patients with COVID-19 and regional selenium status. Moreover, the cure rate continued to rise beyond the selenium intake required to optimise selenoproteins, suggesting that selenoproteins are probably not the whole story. Nonetheless, the significantly reduced expression of a number of selenoproteins, including those involved in controlling ER stress, along with increased expression of IL-6 in SARS-CoV-2 infected cells in culture suggests a potential link between reduced selenoprotein expression and COVID-19-associated inflammation. In this comprehensive review, we describe the history of selenium in viral infections and then go on to assess the potential benefits of adequate and even supra-nutritional selenium status. We discuss the indispensable function of the selenoproteins in coordinating a successful immune response and follow by reviewing cytokine excess, a key mediator of morbidity and mortality in COVID-19, and its relationship to selenium status. We comment on the fact that the synthetic redox-active selenium compound, ebselen, has been found experimentally to be a strong inhibitor of the main SARS-CoV-2 protease that enables viral maturation within the host. That finding suggests that redox-active selenium species formed at high selenium intake might hypothetically inhibit SARS-CoV-2 proteases. We consider the tactics that SARS-CoV-2 could employ to evade an adequate host response by interfering with the human selenoprotein system. Recognition of the myriad mechanisms by which selenium might potentially benefit COVID-19 patients provides a rationale for randomised, controlled trials of selenium supplementation in SARS-CoV-2 infection.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Selenium and selenoproteins in viral infection with potential relevance to COVID-19

et al. 2020

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“…In their study, the concentration of interleukin-6 negatively correlated with the concentration of selenium in the group of elderly patients [24]. Not all the studies published, however, have provided consistent results.…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines—Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis

Prystupa

Kiciński

Luchowska-Kocot

et al. 2017

IJERPH

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According to some authors, serum selenium levels are strongly associated with the severity of liver diseases, including liver cirrhosis. The aim of this study was to determine the relationship between the concentration of selenium and pro-inflammatory and profibrotic cytokines—interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. The parameters studied were determined in the serum of 99 patients with alcoholic liver cirrhosis divided based on the severity of disease according to the Child-Turcotte-Pugh criteria. In patients with liver cirrhosis, the serum selenium concentration was statistically lower, whereas serum IL-6 and GDF-15 concentrations were higher than those in the control group. Moreover, the concentration of selenium negatively correlated with the levels of GDF-15 and IL-6. The above results may indicate a role of selenium deficiency in the pathogenesis and progression of alcoholic liver disease.

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“…Moreover, Chang and Tsai 79 reported that MeHg causes IL-6 production and cytotoxicity simultaneously and Nechemia-Arbely et al 80 found that administration of HgCl 2 to mice results in rapid and substantial elevation in serum IL-6 level concurrent with the development of acute kidney injury. Tseng et al 81 demonstrated that serum selenium is inversely associated with inflammatory cytokine (IL-6) among elderly living in long-term care facilities in Taiwan. Shilo et al 82 observed that selenium supplementation strongly attenuates the blood IL-6 elevation.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective potential of selenium and taurine against mercuric chloride induced nephropathy in rats

et al. 2014

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Department of Hormones, National Research Centre, Cairo, Egypt AbstractThe study was aimed to estimate whether pre-treatment with sodium selenite or taurine would reverse kidney damage induced by intraperitoneal injection of mercuric chloride in rats. Animals were divided into six groups: (1) control group; (2) sodium selenite group; (3) taurine group; (4) HgCl 2 group; (5) sodium selenite pretreated group; (6) taurine pretreated group. The results demonstrated that HgCl 2 causes significant enhancement in serum malondialdehyde (MDA), creatinine, N-acetyl-beta-D-glucosaminidase (NAG), cystatin C, nephrin and interleukin 6 (IL-6) levels accompanied with significant reduction in serum nitric oxide (NO) level. Pretreatment with sodium selenite or taurine produces significant depletion in MDA, NAG, cystatin C, nephrin and IL-6 levels in concomitant with significant elevation in serum NO level as compared to HgCl 2 group. HgCl 2 induced pathological alterations in the kidney. The ultrastructural investigation of renal cortex of HgCl 2 -administered group revealed that the glomerular basement membrane is uniform, the fenestrations of endothelial cells are swollen, and the secondary foot processes appear also swollen even fused at some points. The proximal convoluted tubules showed apical short and few microvilli, while, some tubular cells showed relatively normal microvilli. In contrast, sodium selenite or taurine pretreatment could significantly reduce the pathological alterations in the kidney caused by HgCl 2 intoxication. The current results suggested that selenium and taurine possess nephroprotective efficacy due to their antioxidative capacity and anti-inflammatory activity.

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Selenium is inversely associated with interleukin-6 in the elderly

Abstract: Serum selenium was inversely associated with inflammatory cytokine interleukin-6 among elderly living in long-term care facilities in Taiwan. Monitoring serum selenium should be considered in these institutionalized elderly.

Cited by 33 publications

References 31 publications

Selenium and selenoproteins in viral infection with potential relevance to COVID-19

Selenium and selenoproteins in viral infection with potential relevance to COVID-19

Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines—Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis

Nephroprotective potential of selenium and taurine against mercuric chloride induced nephropathy in rats

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