Selenium levels and skin diseases: systematic review and meta-analysis

Lv, Jun; Ai, Ping; Lei, Shu-Ying; Zhou, Fa-Qiong; Chen, Shang-Zhou; Zhang, Yang

doi:10.1016/j.jtemb.2020.126548

Cited by 26 publications

(14 citation statements)

References 29 publications

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“…Some studies suggest that there is a sex-specific impact of Se on inflammatory responses, as there is an degree of sexual dimorphism among the distribution of Se in organs of the body that affects Se status and arrangement related to body function [82]. Chronic inflammatory syndromes are usually linked with a reduction in Se status and some studies have revealed that patients with cystic fibrosis [39,83], inflammatory bowel diesease, and acne [84] may have a lower status of Se than healthy controls. SelS (selenocysteine-containing proteins), whose secretions from liver cells and human serum recognition have also been published, is one of the SePs involved in immune responses [85,86].…”

Section: Se and Inflammatory Responsementioning

confidence: 99%

A Comprehensive Review on Selenium and Its Effects on Human Health and Distribution in Middle Eastern Countries

Kieliszek

Bano

Zare

2021

Biol Trace Elem Res

105

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Selenium (Se) is an important microelement with numerous positive effects on human health and diseases. It is important to specify that the status and consumption of Se are for a specific community as the levels of Se are extremely unpredictable between different populations and regions. Our existing paper was based on the impacts of Se on human health and disease along with data on the Se levels in Middle Eastern countries. Overall, the findings of this comprehensive review show that the consumption and levels of Se are inadequate in Middle Eastern nations. Such findings, together with the growing awareness of the importance of Se to general health, require further work primarily on creating an acceptable range of blood Se concentration or other measures to determine optimal Se consumption and, consequently, to guarantee adequate Se supplementation in populations at high risk of low Se intake.

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Section: Se and Inflammatory Responsementioning

confidence: 99%

A Comprehensive Review on Selenium and Its Effects on Human Health and Distribution in Middle Eastern Countries

Kieliszek

Bano

Zare

2021

Biol Trace Elem Res

105

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“…In one meta-analysis, psoriasis patients had higher selenium levels in hair, lower in blood, and equal in serum and plasma. 96 …”

Section: Resultsmentioning

confidence: 99%

Dietary Intervention and Supplements in the Management of Psoriasis: Current Perspectives

Chung¹,

Bartholomew²,

Yeroushalmi³

et al. 2022

PTT

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Nutrition is a complex topic encompassing diet and a variety of supplements including vitamins, fish oil, herbal products, and probiotics. Patients with psoriasis display high interest in understanding the potential impact of nutritional modifications on their psoriasis. In this review, we examine the evidence for nutritional interventions in psoriasis and summarize important concepts. We found that certain diets, such as low-calorie diets for obese patients, gluten-free diets for patients with comorbid celiac disease, and the Mediterranean diet, may have benefits for psoriasis patients. Supplements in general do not show strong evidence of benefit, though more studies are required given the heterogeneity of these trials. Finally, the gut microbiome has drawn considerable interest in recent years, with specific probiotics showing promising results for psoriasis patients and warranting further exploration.

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“…A decrease in selenium levels in the body and the environment is known to increase mortality from AIDS and COVID-19 (Rayman 2012;Song et al 2020;Zhou et al 2020), which is associated with the role of selenium as an antioxidant agent, as well as its action on gene activity in response to HIV or other viral infection.…”

Section: Discussionmentioning

confidence: 99%

“…The anti-inflammatory effect of selenium was first discovered in diabetic rats (Tong et al 2020). It was shown that selenium can influence inflammatory reactions inducing inhibition of NF-kB, which promotes the production of tumor necrosis factor and interleukins (Lv et al 2020).…”

Section: The Important Role Of Selenium and Its Derivativesmentioning

confidence: 99%

Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector

Бєленічев¹,

Gorchakov²,

Samura³

et al. 2021

RRP

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Selenium is an essential component of more than two dozen enzymes and other selenoproteins that play critical roles in reproduction, DNA synthesis, thyroid hormone metabolism, and protection from oxidative damage and infection. Selenium has a protective action against some forms of cancer and cardiovascular diseases, modulates levels of inflammatory mediators, promotes to maintain bone homeostasis and protects against bone loss. Selenium significance as a cardioprotective agent may be associated not only with its antioxidant properties, but also with its ability to prevent inflammation, autophagy, as well as the intrinsic and extrinsic apoptosis pathways. Signaling pathways, such as p-AMPK, PARP, Nrf2, STAT, are involved in the protective effects of selenium. Selenium protects against cardiovascular damage by increasing the survival rate of cardiomyocytes, including a mitochondria-dependent pathway and autophagy through peroxisome proliferator-activated receptors. Research demonstrating neuroprotective and cardioprotective effects of selenium preparations – selenoline, selenocysteine and selenomethionine – is growing at a rapid rate. It has been established that these compounds are able to normalize the levels of heat shock proteins (HSP70), which limit the cytotoxic effects of free radicals, produce energotropic action, prevent a decrease in the membrane mitochondria charge, and the opening of the mitochondrial pore. Also regulate the expression of transmembrane factors NF-kB, c-fos, which is associated with their main biological function of chaperone proteins, providing protection of neurons from damage. In this review, we want to emphasize pharmacological role of Selenium and its derivatives on human health is very complex and has yet to be fully understood.

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Selenium levels and skin diseases: systematic review and meta-analysis

Cited by 26 publications

References 29 publications

A Comprehensive Review on Selenium and Its Effects on Human Health and Distribution in Middle Eastern Countries

A Comprehensive Review on Selenium and Its Effects on Human Health and Distribution in Middle Eastern Countries

Dietary Intervention and Supplements in the Management of Psoriasis: Current Perspectives

Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector

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