Selenium nanoparticles as versatile carriers for oral delivery of insulin: Insight into the synergic antidiabetic effect and mechanism

Deng, Wenji; Xie, Qian; Wang, Huan; Ma, Zhiguo; Wu, Baojian; Zhang, Xingwang

doi:10.1016/j.nano.2017.05.002

Cited by 67 publications

(34 citation statements)

References 33 publications

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“…The pancreatic islet function of Goto Kakizaki rats was estimated by TUNEL assay of pancreatic β-cells after treatment with insulin-loaded selenium nanoparticles (25 IU/kg) daily for 2 weeks. In TUNEL assay, apoptotic cells declined to 2.3 % from initial 17.6 % in the treatment [73].…”

Section: Apoptosis Assaymentioning

confidence: 87%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

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Section: Apoptosis Assaymentioning

confidence: 87%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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“…The study suggests that selenium can potentiate the antidiabetic effect of insulin and serve as a new oral nanocarrier for the hormone. The study also concluded that insulin‐loaded selenium nanoparticles could have the potential to alleviate diabetes‐associated oxidative stress and improve pancreatic β‐cell functions …”

Section: Less Invasive Insulin Deliverymentioning

confidence: 95%

Oral insulin delivery: existing barriers and current counter-strategies

Gedawy

Martinez

Al‐Salami

et al. 2018

Journal of Pharmacy and Pharmacology

134

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Objectives The chronic and progressive nature of diabetes is usually associated with micro-and macrovascular complications where failure of pancreatic b-cell function and a general condition of hyperglycaemia is created. One possible factor is failure of the patient to comply with and adhere to the prescribed insulin due to the inconvenient administration route. This review summarizes the rationale for oral insulin administration, existing barriers and some counter-strategies trialled. Key findings Oral insulin mimics the physiology of endogenous insulin secreted by pancreas. Following the intestinal absorption of oral insulin, it reaches the liver at high concentration via the portal vein. Oral insulin on the other hand has the potential to protect pancreatic b-cells from autoimmune destruction. Structural modification, targeting a particular tissue/receptor, and the use of innovative pharmaceutical formulations such as nanoparticles represent strategies introduced to improve oral insulin bioavailability. They showed promising results in overcoming the hurdles facing oral insulin delivery, although delivery is far from ideal. Summary The use of advanced pharmaceutical technologies and further research in particulate carrier system delivery predominantly nanoparticle utilization would offer useful tools in delivering insulin via the oral route which in turn would potentially improve diabetic patient compliance to insulin and the overall management of diabetes.

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“…The hypoglycemic activity of Se nanoparticles has been critically documented by other research teams. 23,30,31 By comparison, BB-SeNLCs caused more significant hypoglycemic effect, where the maximal blood glucose decline was 33.7%. Of course, the potency of BB-SeNLCs in lowering the blood glucose was inferior to that of subcutaneous insulin.…”

Section: Enhanced Hypoglycemic Effectmentioning

confidence: 95%

“…22,23 Briefly, berberine, oleic acid and Precirol ® ATO 5 were dissolved in an appropriate amount of ethanol (90%, v/v) and then evaporated under vacuum to form a dry lipid film. The solid lipid film was subsequently heated to melt at 60°C.…”

Section: Preparation Of Bb-senlcsmentioning

confidence: 99%

“…The construction of adipocytes using the inguinal fat tissue of SD rats referred to the reported method. 23 The mature adipocytes were seeded in 24-well plates and cultured in 0.2% BSA culture medium with 10 mM of glucose at 37°C. Berberine solution, BB-NLCs or BB-SeNLCs was added into the cells with a final concentration of 2.5 μg/mL.…”

Section: Glucose Utilization Assaymentioning

confidence: 99%

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Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect

Yin¹,

Hou²,

Yin³

et al. 2017

IJN

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Diabetes mellitus is an incurable metabolic disorder that seriously threatens human health. At present, there is no effective medication available to defeat it. This work intended to develop selenium-coated nanostructured lipid carriers (SeNLCs) for enhancing the oral bioavailability and the curative effect of berberine, an antidiabetic phytomedicine. Berberine-loaded SeNLCs (BB-SeNLCs) were prepared by hot-melt dispersion/homogenization procedure followed by in situ reduction. BB-SeNLCs were characterized by particle size, morphology, entrapment efficiency (EE) and in vitro release. Pharmacokinetics of berberine solution, berberine-loaded NLCs (BB-NLCs) and BB-SeNLCs were studied in Sprague Dawley rats administered by oral gavage. The prepared BB-SeNLCs were around 160 nm in particle size with an EE of 90%. In addition, BB-SeNLCs exhibited a better sustained release of berberine compared to the plain NLCs. After oral administration, BB-SeNLCs greatly enhanced the oral bioavailability of berberine, which was approximately 6.63 times as much as that of berberine solution. The hypoglycemic effect of BB-SeNLCs was also significantly superior to that of BB-NLCs and berberine solution. It turned out that sustained drug release and good intestinal absorption, plus the synergy of selenium, were basically responsible for enhanced oral bioavailability and hypoglycemic effect. Our findings show that SeNLCs are promising nanocarriers for oral delivery of berberine to strengthen the antidiabetic action.

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Selenium nanoparticles as versatile carriers for oral delivery of insulin: Insight into the synergic antidiabetic effect and mechanism

Cited by 67 publications

References 33 publications

In vitro and in vivo toxicity assessment of nanoparticles

In vitro and in vivo toxicity assessment of nanoparticles

Oral insulin delivery: existing barriers and current counter-strategies

Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect

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