Selenium plasma levels in psoriasis

Donadini, A.; Fiora, C.; Regazzini, R.; Perini, Daria; Minoia, Claudio

doi:10.1111/j.1365-2230.1992.tb00212.x

Cited by 13 publications

(6 citation statements)

References 8 publications

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“…GPX4 knockout has been proved to induce ferroptosis-related necroinflammation in skin tissue (130)(131)(132). For the reason that ceramide analogs are testified to be an effective therapeutic in animal experiments, it is speculated that upregulating GPX4 might significantly relieve skin from ferroptosis-induced necroinflammatory injury (96,97).…”

Section: Integumentary System Diseasesmentioning

confidence: 99%

Ferroptosis: A Trigger of Proinflammatory State Progression to Immunogenicity in Necroinflammatory Disease

Yao

Tian

2021

Front. Immunol.

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Until recently, necrosis is generally regarded as traumatic cell death due to mechanical shear stress or other physicochemical factors, while apoptosis is commonly thought to be programmed cell death, which is silent to immunological response. Actually, multiple modalities of cell death are programmed to maintain systematic immunity. Programmed necrosis, such as necrosis, pyroptosis, and ferroptosis, are inherently more immunogenic than apoptosis. Programmed necrosis leads to the release of inflammatory cytokines, defined as danger-associated molecular patterns (DAMPs), resulting in a necroinflammatory response, which can drive the proinflammatory state under certain biological circumstances. Ferroptosis as a newly discovered non-apoptotic form of cell death, is characterized by excessive lipid peroxidation and overload iron, which occurs in cancer, neurodegeneration, immune and inflammatory diseases, as well as ischemia/reperfusion (I/R) injury. It is triggered by a surplus of reactive oxygen species (ROS) induced in an imbalanced redox reaction due to the decrease in glutathione synthesis and inaction of enzyme glutathione peroxidase 4 (GPX4). Ferroptosis is considered as a potential therapeutic and molecular target for the treatment of necroinflammatory disease, and further investigation into the underlying pathophysiological characteristics and molecular mechanisms implicated may lay the foundations for an interventional therapeutic strategy. This review aims to demonstrate the key roles of ferroptosis in the development of necroinflammatory diseases, the major regulatory mechanisms involved, and its potential as a therapeutic target.

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Section: Integumentary System Diseasesmentioning

confidence: 99%

Ferroptosis: A Trigger of Proinflammatory State Progression to Immunogenicity in Necroinflammatory Disease

Yao

Tian

2021

Front. Immunol.

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“…Defects in the absorption of selenomethionine from the gut of psoriatic and atopic dermatitis patients did not differ significantly from controls’ [8]. Other studies showed no difference in selenium levels in patients with psoriasis compared with normal controls [9]. In short, the connection between selenium and psoriasis is unclear, with poor understanding of the absorption, handling of inorganic vs organic selenium, and transport of active selenium moieties to the skin.…”

Section: Introductionmentioning

confidence: 99%

Selenium unmasks protective iron armor: A possible defense against cutaneous inflammation and cancer

Arbiser

Bonner

Ward

et al. 2018

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…Serum Se, and (better) whole blood Se levels reflect the current Se status of the individual, and median levels obtained within a region indicate a general level of supply. The difference between Se concentrations in human plasma and whole blood is about 30 % [135]. Apart from local feeding habits, blood plasma and serum levels of coastal populations are generally higher than from inside the continents, thus, seafood is a very significant source of Se (Table 3).…”

Section: Occurrence In Food For Human Nutritionmentioning

confidence: 99%

Selenium in agriculture, food, and nutrition

Sager

2006

Pure and Applied Chemistry

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In the case of Se, the concentration range between essentiality and toxicity for terrestric animals and humans is rather narrow, while aquatic organisms are much less affected, and no essentiality to green plants and aquatic macrophytes has been established yet. This review focuses on the situation in Europe, where Se levels are generally low. Apart from industrial and mining activities, the main Se sources are the burning of coal and selenite additions to animal feedstuffs. Reduction processes in sediments, soils, and feedstuffs to yield elemental Se act as sinks for available Se forms. In soils and crops, Se levels get enhanced from recycling of manure, dung, and sewage sludge, which is beneficial for Europe. New data from Austria have been added to the detailed discussions. In human nutrition, Se is supplied via pork, liver and kidneys, seafood, and cereals, but main sources as well as blood Se levels vary between different countries and nutritional habits. Food processing, like boiling, baking, or grilling, results in Se losses.

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Selenium plasma levels in psoriasis

Cited by 13 publications

References 8 publications

Ferroptosis: A Trigger of Proinflammatory State Progression to Immunogenicity in Necroinflammatory Disease

Ferroptosis: A Trigger of Proinflammatory State Progression to Immunogenicity in Necroinflammatory Disease

Selenium unmasks protective iron armor: A possible defense against cutaneous inflammation and cancer

Selenium in agriculture, food, and nutrition

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