Selenium status during pregnancy: Influential factors and effects on neuropsychological development among Spanish infants

Maternal selenium status and neuropsychological development in Spanish preschool children

“…In a previous study, we reported an inverted U-shaped relationship between maternal Se status and child neuropsychological development evaluated at around 12 months of age, the turning point for this association being estimated at 86 µg/L (Amorós et al, 2018).…”

“…Se concentrations were corrected according to the variations in three daily measures of the Seronorm TM (lot MI0181) reference material. The correction was performed by adding to each measure the difference between the daily mean of the reference measures and the overall mean of the reference measures (Amorós et al, 2018). The MSCA comprise 18 subtests that yield standardized test scores for six conventional domains.…”

“…Very few prospective studies have evaluated the relationship between Se status during pregnancy and child neuropsychological development among populations with intermediate Se levels and the results obtained have been heterogeneous. Thus, positive, negative and null effects on child neuropsychological development have been observed in relationship to prenatal Se levels (Amorós et al, 2018;Kippler et al, 2016;Oken et al, 2016;Polanska et al, 2016;Skröder et al, 2015;Yang et al, 2013) and, in addition, the shape of this association has scarcely been assessed.…”

Pregnancy, thyroid, and the potential use of selenium

“…Additionally, the results were related to the Se metabolic patterns based on child indolethylamine Nmethyltransferase (INMT), AG+AA genotype for rs6970396. A descending curve was proposed for the GG genotype, confirming the important role of individual susceptibility [36]. It is worth mentioning that there is a large variability in the metabolism of Se and in the urinary excretion of its metabolite trimethylselenonium ion (TMSe), and this variability has been strongly linked to a genetic variation of the INMT gene [37].…”

“…An analysis of the association between maternal Se concentrations and child neuropsychological development was performed in the first phase (2003)(2004)(2005) of the Spanish Childhood and Environment Project (INMA) [36]. Six hundred and fifty mother-child pairs were enrolled in the study.…”