Selenium Supplementation and Prostate Health in a New Zealand Cohort

Abstract

Background: There is variable reporting on the benefits of a 200 μg/d selenium supplementation towards reducing prostate cancer impacts. The current analysis is to understand whether stratified groups receive supplementation benefits on prostate health. Methods: 572 men were supplemented with 200 µg/d selenium as selinized yeast for six months, and 481 completed the protocol. Selenium and prostate-specific antigen (PSA) levels were measured in serum at pre- and post-supplementation. Changes in selenium and PSA levels subsequent to supplementation were assessed with and without demographic, lifestyle, genetic and dietary stratifications. Results: The post-supplementation selenium (p = 0.002) and the gain in selenium (p < 0.0001) by supplementation were significantly dependent on the baseline selenium level. Overall, there was no significant correlation between changes in PSA and changes in selenium levels by supplementation. However, stratified analyses showed a significant inverse correlation between changes in PSA and changes in selenium in men below the median age (p = 0.048), never-smokers (p = 0.031), men carrying the GPX1 rs1050450 T allele (CT, p = 0.022 and TT, p = 0.011), dietary intakes above the recommended daily intake (RDI) for zinc (p < 0.05), and below the RDI for vitamin B12 (p < 0.001). Conclusions: The current analysis shows the influence of life factors on prostate health benefits of supplemental selenium.

The association between dietary fatty acid intake and the risk of developing preeclampsia: a matched case–control study

“…The consumed nutrients (g/d or mg/d) and energy (kcal/d) were calculated based on the Chinese Food Composition Tables 2004, which include the nutrient portion and energy of each food item 46 . Some information was excluded, such as individuals whose energy intake was < 600 kcal or > 4000 kcal 47 and those who ate < 4 food items, as their FFQs were considered incomplete 48 .…”

The Role of Selenium in Pathologies: An Updated Review

“…Overall, there was no significant correlation between changes in PSA and changes in selenium levels by supplementation, showing the interactive influence of supplemented selenium with demographic, lifestyle, genetic and dietary factors, on prostate stability measured through serum PSA. This highlights the importance of optimizing serum selenium levels on a personalized scale, rather than depending on a continuous single dose selenium supplement, for prostate health benefits [ 83 ].…”

Zinc in Prostate Health and Disease: A Mini Review

“…The authors were also able to demonstrate the ability of an IC 50 of 50 µM Zn 2+ or 150 µM of Cd 2+ to be able to suppress the specific activity of PSA purified from human plasma, while other divalent ions Cu 2+ , Mn 2+ , Fe 2+ , and Mg 2+ were either unable to do such suppression or were weaker [ 142 ]. A 200 µg/d Se supplementation for six months in men without cancer from Auckland, New Zealand has shown that PSA suppression with supplementation was seen only in stratified groups of men including those having a Zn dietary intake above 14 mg/d [ 143 ].…”