Selenium, Zinc and Copper in Plasma of patients with Type 1 Diabetes Mellitus in Different Metabolic Control States

Ruiz, Claudio; Alegrı́a, Amparo; Barberá, Reyes; Farré, R.; Lagarda, Marı́a Jesús

doi:10.1016/s0946-672x(98)80031-x

Cited by 66 publications

(45 citation statements)

References 24 publications

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“…The element Se was decreased in the plasma of patients with diabetes, and -consistent with the findings of Kruse-Jarres et al [16] -the current study did not demonstrate any significant difference in the levels of Se between children with T1DM and the controls. However, a decreased level of Se in patients with diabetes, regardless of their gender and age, was reported in a study by Nawarro-alarcon et al [26], and a negative correlation with Hba 1c in a study by Ruiz et al [27] The results of the current study did not demonstrate that Se had any effect on metabolic control or the duration of diabetes. The level of Se correlated positively with the activity of erythrocyte GSH-Px, a Se-dependent enzyme.…”

Section: Discussioncontrasting

confidence: 62%

“…The present study revealed a Zn deficiency in T1DM; similar observations were reported by Rohn et al [35], who emphasized the significance of Zn supplementation in patients with diabetes. Ruíz et al [36] did not note any differences in the levels of Zn between patients with T1DM and the controls. In the present study, a positive correlation was observed between the levels of Zn and TaS in children with T1DM, which confirms the antioxidative role of this element.…”

Section: Cuznsodmentioning

confidence: 86%

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Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

Salmonowicz¹,

Krzystek−Korpacka²,

Noczyńska³

2014

Adv Clin Exp Med

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Background. Magnesium (Mg), selinium (Se), zinc (Zn), manganese (Mn), and copper (cu) are involved in the mechanisms of antioxidant defense. Mn and cu, which participate in the generation of reactive oxygen species (ROS), also have pro-oxidative properties. Objectives. To evaluate the levels of Mg, Se, Zn, Mn, and cu, as well as the effectiveness of antioxidant defense mechanisms in children with Type 1Diabetes Mellitus (T1DM) and in their siblings. The preliminary findings were originally reported in 2009 at the 35 th annual conference of the International Society for Pediatric and adolescent Diabetes (ISPaD) in Ljubljana, Slovenia. Material and Methods. The study involved 87 children with T1DM, 2-19 years old, treated for T1DM for an average of 3.5 years. The sibling and control groups comprised 27 and 41 children, aged 4.5-16.5 years and 10.5-18 years respectively. The parameters named above were assessed in relation to metabolic compensation levels (Hb a1c ) and disease duration. Results. compared with the control group, T1DM children had lower plasma levels of Mg and Zn and higher levels of cu; the siblings had lower levels of Zn; T1DM children had lower copper/zinc superoxide dismutase (cuZnSOD) activity; and both T1DM children and their siblings had higher catalase (caT) activity and lower total antioxidant status (TaS) levels. Conclusions. There may be a correlation between impaired antioxidant status and Mg and Zn deficiency and increased cu levels in T1DM children. Oxidative stress in T1DM is accompanied by alterations in enzymatic activity and non-enzymatic mechanisms of antioxidant defense. The decreased TaS levels noted in T1DM patients may impair the effectiveness of non-enzymatic antioxidant systems. The increased caT activity and unimpaired selenium-dependent glutathione peroxidase (Se-GSHPx) activity point indirectly to enhanced ROS generation in T1DM children. The impaired antioxidant defense found in the siblings of T1DM patients may indicate that genetic factors play a role (Adv Clin Exp Med 2014, 23, 2, 259-268).

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Section: Discussioncontrasting

confidence: 62%

Section: Cuznsodmentioning

confidence: 86%

Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

Salmonowicz¹,

Krzystek−Korpacka²,

Noczyńska³

2014

Adv Clin Exp Med

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“…Additionally, in another study, serum level of selenium in patients with diabetes mellitus was determined compared with the control group. In the diabetic group that included 150 diabetic patients aged 11 to 60 years, the average concentration of plasma selenium significantly lower than the control group (Ruiz, Alegria, Barbera, Farre, & Lagarda, 1998). Similar to our study, in a study conducted in 2012 in diabetic patients aged 40 to 60 years, serum level of selenium in the diabetic group showed a significant decrease in comparison to the control group (Kumar, 2012).…”

Section: Discussionsupporting

confidence: 85%

Serum Selenium Status in Patients with Type 2 Diabetes and Control Group

Heidari

Sepehri

Doostdar

2016

GJHS

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In addition to known risk factors, the role of different micronutrients such as selenium in diabetes incidence has been proposed. Some previous studies have shown an association of selenium deficiency and type 2 diabetes mellitus, while other studies have not confirmed such a relationship. The aim of this study was to evaluate serum level of selenium in patients with Type 2 diabetes compared with the control group. This cross-sectional study was carried out on patients with type 2 diabetes in Zahedan, southeastern Iran. One hundred newly diagnosed type 2 diabetic patients were evaluated for serum selenium level. One hundred subjects from the general population who had normal fasting blood sugar levels were selected as the control group. The control group subjects were matched in pairs with each of patients on the basis of sex, age (± one year), and body mass index (±1). Serum level of selenium was determined by spectrometry method. Results were compared using t-test. The mean serum level of selenium in patients was 94.47±18.07 µg/L whereas in control group was 142.79±23.67 µg/L. The mean serum level of selenium was significantly different between the two groups (P<0.001). Serum levels of selenium in diabetic patients with significant difference statistically were lower than the control group. In order to evaluate serum level of selenium in patients with diabetes, studies with larger sample size are required. Likewise, prospective studies along with selenium supplementation and investigating its effect on incidence of diabetes are accordingly needed.

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“…In the present study, a Science Publications AJAVS 4.5% decrease in serum selenium levels was observed in the diabetic control group. Ruiz et al (1998) reported that the mean plasma selenium levels were significantly lower in diabetic patients. Selenium levels in type-1 diabetic children were higher than normal children (Gebre et al, 1984).…”

Section: Discussionmentioning

confidence: 98%

“…In Se-deficient rats, insulin secretory reserve was significantly reduced and glucose intolerance developed in rats maintained on selenium and vitamin E-deficient diets (Mooradian and Morley, 1987). Ruiz et al (1998) reported that the mean plasma selenium and copper levels in diabetic patients were significantly lower than the control group. Under conditions of Cu deficiency, several components of the oxidant defense system can be compromised.…”

Section: Intoductionmentioning

confidence: 99%

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

Sajedianfard¹,

Nazifi²,

Shamsaei³

2014

American Journal of Animal and Veterinary Sciences

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In this research, the effect of oral administration of different doses of hydroalcoholic extract of silymarin on the status of trace elements with antioxidant properties (Se, Cu, Zn, Mn and Fe) was studied. Fifty male rats were randomly used in five groups including healthy control group (treated by saline), diabetic control group (treated by saline) and three diabetic groups that were daily treated by different oral dose of silymarin (100, 175 and 250 mg kg −1 ). Diabetes was induced by intraperitoneal injection of streptozotocin (50 mg kg −1 ) in rats. Rats were orally treated for 14 days by gavage. Weight was measured before STZ injection, 7 and 14 days after treatment. The blood glucose was measured before injection of STZ, 3 days after injection and 7 and 14 days after diabetes was induced (under treatment by silymarin). At the end of the study, blood samples were taken by heart puncture. Results showed that the average weight increased during the 14 days of treatment with silymarin and the blood glucose was decreased. Hydroalcoholic extract of silymarin increased trace elements levels in treated groups by dose-dependent manner. The present study showed that in diabetic rats, high therapeutic doses of silymarin had a major effect on serum antioxidant factors. Results also showed that hydroalcoholic extract of silymarin increased the body weight and decreased serum glucose concentration at the end of the treatment period. Silymarin in a dose dependent manner could improve trace element levels in diabetic rats. Therefore, it may cause reduction of oxidative stress in the diabetic rats.

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Selenium, Zinc and Copper in Plasma of patients with Type 1 Diabetes Mellitus in Different Metabolic Control States

Cited by 66 publications

References 24 publications

Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

Serum Selenium Status in Patients with Type 2 Diabetes and Control Group

The Effects of Oral Administration of Different Doses of Hydroalcoholic Extract of Silymarin on Status of Serum Trace Elements

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