Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range

Kobayashi, Yayoi; Ogra, Yasumitsu; Ishiwata, Kazuya; Takayama, Hiromitsu; Aimi, Norio; Suzuki, Kazuo

doi:10.1073/pnas.252610699

Cited by 274 publications

(245 citation statements)

References 26 publications

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“…However, Se is mainly excreted into urine under physiological conditions as selenosugar. 31,32 Although Te is a non-essential metalloid, it is expected to be metabolized in the same pathway as that of an excess amount of Se, an essential metalloid. Thus, This compound also acts as an immunomodulator, i.e., it inhibits the activation of interleukin-1β.…”

Section: ·1 Tellurium In Biology Toxicology and Medicinementioning

confidence: 99%

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Toxicometallomics for Research on the Toxicology of Exotic Metalloids Based on Speciation Studies

Ogra

2009

ANAL. SCI.

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Tellurium and antimony are widely used in industry because of their unique chemical and physical properties. Although these metalloids, which belong to period 5 of the periodic table of elements, are known to be non-essential and harmful, or the so-called "exotic" elements, little is known about their toxic effects and metabolism. The present review describes the role of speciation in considering the metabolism of tellurium and antimony from the viewpoint of toxicometallomics. Inorganic tellurium in the form of tellurite is reduced and simply methylated in the body. Rat red blood cells accumulate tellurium in the form of dimethylated tellurium, and tellurium is excreted into urine as trimethyltelluronium. Although selenium, which belongs to the same group as tellurium, is known to be excreted in the form of selenosugar as the major urinary metabolite, tellurosugar was not detected by an inductively coupled plasma-mass spectrometer hyphenated with an HPLC. Speciation studies revealed that the major metabolic pathway of antimony is oxidation in human and rat, and methylation also occurs as a minor metabolic pathway in humans.

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Section: ·1 Tellurium In Biology Toxicology and Medicinementioning

confidence: 99%

“…Within the nutritional and low toxicity range of Se ingested, selenide is primarily metabolized into selenosugar. 32 Three species of selenosugars were detected as urinary Se metabolites,…”

Section: ·2 Metabolism Of Tellurium Based On the Characterizationmentioning

confidence: 99%

Toxicometallomics for Research on the Toxicology of Exotic Metalloids Based on Speciation Studies

Ogra

2009

ANAL. SCI.

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“…Currently, four selenosugars were identified in liver, serum and urine of quail [34], turtle [35], rat [36], porcine [37], and human [38], including methyl-2-acetamido-2-deoxy-1-seleno-β-D-galactopyranoside (selenosugar 1) [39,40], methyl-2-acetamido-2-deoxy-1-seleno-β-D-glucosopyranoside (selenosugar 2) [40], and methyl-2-amino-2-deoxy-1-seleno-β-D-galactopyranoside (selenosugar 3) [40] and selenosugar A [41]. In urine samples, selenosugar 1 is the major metabolite.…”

Section: Speciation Of Sementioning

confidence: 99%

Recent advances in speciation analysis of mercury, arsenic and selenium

2012

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Mercury (Hg), arsenic (As) and selenium (Se) are ubiquitous in the environment and exist in a variety of species, which have great influence on their transport, bioaccumulation and toxicity. This review presents the recent research progress in speciation analysis of Hg, As, and Se, with emphasis on enhanced cold vapor generation as interface for liquid chromatography and atomic spectrometry, speciation of volatile species in gas phase, and isotope dilution technique to improve the precision and accuracy of speciation. Hyphenated techniques to characterize the complexes of Hg and As with phytochelatins and chromatographic separation coupled with multi-collector-inductively coupled plasma mass spectrometry to measure species-specific isotopic ratios, are also briefly discussed. Mercury (Hg) and arsenic (As) are among the most highly toxic elements for humans and ecosystems and can cause serious environmental and human health problems even at low concentrations [1,2]. Selenium (Se) is an "essential toxin" for human health. It has been recognized as an important antioxidant and anti-cancer element. However, Se can also pose negative impact such as defective skin and hair loss [3]. The adsorption/uptake, transport, bioaccumulation, metabolism and toxicity of these elements strongly depend on their chemical species present in environmental and biological samples. In the environment, one species can transform to another through chemical or biological processes. For example, in anaerobic sediments, sulfur-reducing or iron-reducing bacteria can methylate inorganic mercury into highly toxic methylmercury (MeHg) [4,5]. Therefore, speciation analysis of Hg, As and Se is of great importance in order to elucidate the biogeochemcal cycle and toxicology of these elements. Speciation analysis mainly involves chromatographic separation (gas chromatography (GC) or high performance liquid chromatography (HPLC)) hyphenated with element-specific spectrometry or molecular mass spectrometry. This review presents the recent advances in speciation analysis of Hg, As, and Se based on chromatographic separation, with emphasis on enhanced cold vapor generation (CVG) as interface for LC and atomic spectrometry, speciation of volatile Hg, As and Se in gas phase, and isotope dilution technique to improve the precision and accuracy of speciation. Hyphenated techniques to characterize the complexes of Hg and As with phytochelatins and chromatographic separation coupled with multi-collector-inductively coupled plasma mass spectrometry (MC-ICP-MS) to measure species-specific isotopic ratios, are also briefly introduced.

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“…As a complementary technique to LC-ICP-MS, electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI)-mass spectrometry was used for the identification of unknown Se-containing metabolites in biological samples. [10][11][12][13][14][15] Since ESI is a softer technique than ICP, it can provide molecular information. 16 Hence, ICP-MS and ESI/APCI-MS are occasionally called inorganic and organic mass spectrometry, respectively.…”

Section: Introductionmentioning

confidence: 99%

Complementary Use of LC-ICP-MS and LC-ESI-Q-TOF-MS for Selenium Speciation

2015

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Experimental ReagentsSodium selenate and ammonium acetate were purchased from Wako (Osaka, Japan).L-Selenomethionine (SeMet) and trimethylselenonium iodide (TMSe) were purchased from Sigma (St. Louis, MO) and Tri Chemical Laboratories, Inc. 2015 © The Japan Society for Analytical Chemistry † To whom correspondence should be addressed. E-mail: ogra@chiba-u.jp Complementary Use of LC-ICP-MS and LC-ESI-Q-TOF-MS for Selenium SpeciationYasumi ANAN,* Genki NAKAJIMA,* and Yasumitsu OGRA* , ** † We demonstrated the complementary use of inductively coupled plasma-mass spectrometry (ICP-MS) and electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-Q-TOF-MS) for the analysis of Se-containing compounds, such as selenate, selenomethionine (SeMet), and trimethylselenonium ion (TMSe), found in biological samples. The sensitivity of ESI-Q-TOF-MS for Se-containing compounds was strongly dependent on the chemical species. ICP-MS exhibited higher sensitivity than ESI-Q-TOF-MS, and had no species dependency. On the other hand, ESI-Q-TOF-MS enabled easy and robust identification of Se-containing compounds.

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Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range

Cited by 274 publications

References 26 publications

Toxicometallomics for Research on the Toxicology of Exotic Metalloids Based on Speciation Studies

Toxicometallomics for Research on the Toxicology of Exotic Metalloids Based on Speciation Studies

Recent advances in speciation analysis of mercury, arsenic and selenium

Complementary Use of LC-ICP-MS and LC-ESI-Q-TOF-MS for Selenium Speciation

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