Self-assembled albumin nanoparticles for combination therapy in prostate cancer

Lian, Huibo; Wu, Jinhui; Hu, Yiqiao; Guo, Hongqian

doi:10.2147/ijn.s144634

Cited by 52 publications

(28 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CUR/IR780@SMEDDS treatment with exposure to NIR irradiation exhibited the highest cytotoxicity, consistent with high ROS production. This observation implies that ROS generated by CUR/IR780@SMEDDS upon laser irradiation may induce cellular death, in agreement with a previous report 44. Additionally, in the ROS detection assay, CUR/IR780@SMEDDS treatment without NIR irradiation showed very light fluorescence compared to the control group (Figure 4B), which might be caused by intrinsic ROS generation capacity of curcumin.…”

Section: Resultssupporting

confidence: 92%

<p>Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer</p>

Liu¹,

Huang²,

Hou³

et al. 2019

IJN

View full text Add to dashboard Cite

Background: Oral route of administration is preferred for treating breast cancer, especially when continued disease management with good tolerability is required; however, orally administered chemotherapeutics combined with near-infrared (NIR) dyes are hindered by the low bioavailability, insufficient for the desired therapeutic efficacy. In this study, we developed a hybrid self-microemulsifying drug delivery system for co-loading curcumin–phospholipid complex and NIR dye IR780 (CUR/IR780@SMEDDS), to achieve combined phototherapeutic and chemotherapeutic effects against lung metastasis of breast cancer. Methods: CUR/IR780@SMEDDS were characterized. The efficacy against breast cancer metastasis was evaluated by photothermal and photodynamic assessment, cytotoxicity, invasion, and migration in metastatic 4T1 breast cancer cells in vitro, and in vivo oral bioavailability study in rats and pharmacodynamics studies in tumor-bearing nude mice. Results: CUR/IR780@SMEDDS improved oral bioavailability of curcumin and IR780 in rats compared with curcumin and IR780 suspensions. CUR/IR780@SMEDDS exhibited remarkable photothermal and photodynamic effects in vitro. In metastatic 4T1 breast cancer cells, CUR/IR780@SMEDDS combined with localized NIR laser irradiation induced significant cytotoxicity and inhibited invasion and migration of 4T1 cells, an outcome attributable to cumulative effects of IR780-induced hyperthermia and pharmacological effects of curcumin. In orthotopic 4T1 tumor-bearing nude mice, combination of oral administration of CUR/IR780@SMEDDS with local NIR laser irradiation inhibited tumor progression and suppressed lung metastasis.

show abstract

Section: Resultssupporting

confidence: 92%

<p>Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer</p>

Liu¹,

Huang²,

Hou³

et al. 2019

IJN

View full text Add to dashboard Cite

show abstract

“…The positive example of using albumin nanoparticles in antitumor treatment is confirmed by a successful application and FDA approval of Abraxane ® (Celegene Corporation, Summit, NJ, USA) (paclitaxel incorporated in albumin nanoparticles for a metastatic breast cancer, non-small cell lung carcinoma, pancreatic cancer, cervical cancer [66,67,68,69,70]. Albumin based nanoparticles loaded with lapatinib (triple negative breast cancer and HER2-positive breast cancer), gemcitabine (pancreatic cancer), siRNAs (breast and lung cancers), gold nanoparticles for NSCLC, photosensitizers are also being developed [71,72,73,74,75,76,77].…”

Section: Passive Targetingmentioning

confidence: 99%

Targeted Delivery to Tumors: Multidirectional Strategies to Improve Treatment Efficiency

Kutova

Guryev

Соколова

et al. 2019

Cancers

View full text Add to dashboard Cite

Malignant tumors are characterized by structural and molecular peculiarities providing a possibility to directionally deliver antitumor drugs with minimal impact on healthy tissues and reduced side effects. Newly formed blood vessels in malignant lesions exhibit chaotic growth, disordered structure, irregular shape and diameter, protrusions, and blind ends, resulting in immature vasculature; the newly formed lymphatic vessels also have aberrant structure. Structural features of the tumor vasculature determine relatively easy penetration of large molecules as well as nanometer-sized particles through a blood–tissue barrier and their accumulation in a tumor tissue. Also, malignant cells have altered molecular profile due to significant changes in tumor cell metabolism at every level from the genome to metabolome. Recently, the tumor interaction with cells of immune system becomes the focus of particular attention, that among others findings resulted in extensive study of cells with preferential tropism to tumor. In this review we summarize the information on the diversity of currently existing approaches to targeted drug delivery to tumor, including (i) passive targeting based on the specific features of tumor vasculature, (ii) active targeting which implies a specific binding of the antitumor agent with its molecular target, and (iii) cell-mediated tumor targeting.

show abstract

“…Similar findings have been previously reported for other nanoformulations co-encapsulating multiple agents. [14,36,37] Finally, the morphology of IR/SBMA-BSA NPs ( Figure 1D) and IR+DOX/SBMA-BSA NPs ( Figure 1E) was analyzed by TEM, suggesting that both formulations have a spherical shape. This spherical morphology has also been observed in other formulations prepared by the nanoprecipitation technique.…”

Section: Preparation and Characterization Of Ir/sbma-bsa Nps And Ir+dmentioning

confidence: 99%

Assessing the Combinatorial Chemo‐Photothermal Therapy Mediated by Sulfobetaine Methacrylate‐Functionalized Nanoparticles in 2D and 3D In Vitro Cancer Models

Mó

Alves

Melo‐Diogo

et al. 2020

Biotechnology Journal

View full text Add to dashboard Cite

Combinatorial cancer therapies mediated by nanomaterials can potentially overcome the limitations of conventional treatments. These therapies are generally investigated using 2D in vitro cancer models, leading to an inaccurate screening. Recently, 3D in vitro spheroids have emerged in the preclinical testing stage of nanomedicines due to their ability to mimic key features of the in vivo solid tumors. Investigate the chemo-photothermal therapy mediated by Doxorubicin and IR780 loaded sulfobetaine methacrylate functionalized nanoparticles, for the first time, using monolayers of cancer cells and spheroids. In the 2D cancer models, the nanomaterials' mediated photothermal therapy, chemotherapy, and chemo-photothermal therapy reduced cancer cells' viability to about 58%, 29%, and 1%, respectively. Interestingly, when the nanomaterials' mediated photothermal therapy is tested on 3D spheroids, no cytotoxic effect is noticed. In contrast, the nanostructures' induced chemotherapy decreased spheroids' viability to 42%. On the other hand, nanomaterials' mediated chemo-photothermal therapy diminished spheroids' viability to 16%, being the most promising therapeutic modality. These results demonstrate the importance of using 3D spheroids during the in vitro screening of single/combinatorial therapies mediated by nanomaterials.

show abstract

Self-assembled albumin nanoparticles for combination therapy in prostate cancer

Cited by 52 publications

References 20 publications

<p>Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer</p>

<p>Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer</p>

Targeted Delivery to Tumors: Multidirectional Strategies to Improve Treatment Efficiency

Assessing the Combinatorial Chemo‐Photothermal Therapy Mediated by Sulfobetaine Methacrylate‐Functionalized Nanoparticles in 2D and 3D In Vitro Cancer Models

Contact Info

Product

Resources

About