Self-assembled drug delivery systems

Microtubes self-assembled from a cholesterol-modified nucleoside

“…cholesteryl-succinyl acyclovir. 11 To the best of our knowledge, however, the present work is the first report on the self-assembly of microtubes from a cholesteryl-nucleoside .…”

Monolayers of the lipid derivatives of isoniazid at the air/water interface and the formation of self-assembled nanostructures in water

“…The lipid derivatives of INH had typically amphiphilic structures, wherein INH or together with succinyl or THTT ring was considered as the polar head. In comparison with the lipid derivatives of nucleosides [5,10], the polar heads of these INH derivatives were smaller, but larger than the carboxyl groups of fatty acids.…”

“…An injection method was used to prepare the self-assemblies of derivatives in water according to our previous work [5,10]. The derivatives were dissolved in a water-miscible organic solvent, tetrahydrofuran (THF).…”

“…The lipid derivatives of antiviral nucleoside analogues were prepared in our previous work, and the water-dispersed selfassembled vesicles were formed to become potential SADDS [10]. Like nucleosides, INH is a polar compound.…”

Self-assemblies of 5′-cholesteryl-ethyl-phosphoryl zidovudine

“…Compared to traditional drug carriers, SADDS can deliver themselves in vivo with the unique advantages of high drug loads, no drug leakage, and controlled drug release at the targets. Some anti-HIV SADDSs has been prepared in our lab, including cholesteryl-succinyl didanosine (CSD), cholesteryl-adipoyl didanosine (CAD), cholesteryl-succinyl zidovudine (CSZ), cholesterylphosphonyl zidovudine (CPNZ), pentadecanedioyl dizidovudine (PDDZ), zidovudinephosphoryl-deoxycholyl didanosine (ZPDD) [25][26][27][28]. They likely self-assembled to nanoassemblies with different morphologies in water [29].…”