Self-assembled liposomes from electrosprayed polymer-based microparticles

Jin, Cheng-Cheng; Li, He-yu; Williams, Gareth R.; Wei, Ran; Nie, Huali; Quan, Jing; Zhu, Li‐Min

doi:10.1007/s00396-014-3222-z

Cited by 5 publications

(9 citation statements)

References 29 publications

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“…Furthermore, liposomes can also be produced by ES (Figure 5j), which have been demonstrated by Jin et al for use as a drug delivery system [32]. The liposomes were fabricated by dissolving different concentrations of PNIPAAm in PC, and in a chloroform/EtOH solvent mixture (1:…”

Section: Types Of Microparticles Made By Es and Their Applicationsmentioning

confidence: 86%

“…Moreover, ES settings can be varied by changing the collector. There are several types of collectors used to obtain particles, such as aluminum plates [31][32][33], stainless steel plates [34,35], steel plates covered with foil [15,32] and the receiver solution [28,[36][37][38][39], which are all demonstrated in Figure 2a-d. Moreover, previous studies have demonstrated the use of alcohol solutions, buffers and surfactants as the MP receptor solution [28,[36][37][38][39].…”

Section: Types Of Configurationmentioning

confidence: 99%

“…Furthermore, thermosensitive MPs composed of poly(N-isopropylacrylamide) (PNIPAAm)/phosphatidylcholine (PC) have been produced by ES at 25 ± 2 • C with 50 ± 5% RH [32]. According to the authors, the selected operating temperature was due to the fact that the MPs were thermosensitive.…”

Section: Temperature and Humiditymentioning

confidence: 99%

“…According to the authors, the selected operating temperature was due to the fact that the MPs were thermosensitive. In their experiments, they analyzed the amount of drug release both at 25 • C and at 37 • C. Therefore, if the material responds to elevated temperatures, the ES system would necessarily have to be operated at lower temperatures [32].…”

Section: Temperature and Humiditymentioning

confidence: 99%

“…A very simple process consisting of a conventional ES system was used for the preparation of the liposome based particles that involved a syringe pump adjusted with a flow of 1.0 mL/h, high voltage set at 16 kV, and a needle with an internal diameter of 0.2 mm. The collector used was a flat plate wrapped in aluminum foil fixed 25 cm away from the tip of the needle [32]. The temperature and humidity of the environment in which the ES was carried out were 25 ± 2 • C and 50 ± 5% RH.…”

Section: Types Of Microparticles Made By Es and Their Applicationsmentioning

confidence: 99%

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Fabrication of Polymeric Microparticles by Electrospray: The Impact of Experimental Parameters

Morais

Vieira

Afewerki

et al. 2020

JFB

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Microparticles (MPs) with controlled morphologies and sizes have been investigated by several researchers due to their importance in pharmaceutical, ceramic, cosmetic, and food industries to just name a few. In particular, the electrospray (ES) technique has been shown to be a viable alternative for the development of single particles with different dimensions, multiple layers, and varied morphologies. In order to adjust these properties, it is necessary to optimize different experimental parameters, such as polymer solvent, voltage, flow rate (FR), type of collectors, and distance between the collector and needle tip, which will all be highlighted in this review. Moreover, the influence and contributions of each of these parameters on the design and fabrication of polymeric MPs are described. In addition, the most common configurations of ES systems for this purpose are discussed, for instance, the main configuration of an ES system with monoaxial, coaxial, triaxial, and multi-capillary delivery. Finally, the main types of collectors employed, types of synthesized MPs and their applications specifically in the pharmaceutical and biomedical fields will be emphasized. To date, ES is a promising and versatile technology with numerous excellent applications in the pharmaceutical and biomaterials field and such MPs generated should be employed for the improved treatment of cancer, healing of bone, and other persistent medical problems.

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Section: Types Of Microparticles Made By Es and Their Applicationsmentioning

confidence: 86%