Self-assembled micelles based on hydrophobically modified quaternized cellulose for drug delivery

Song, Yongbo; Zhang, Lingzhi; Gan, Weiping; Zhou, Jinping; Zhang, Lina

doi:10.1016/j.colsurfb.2010.11.039

Cited by 111 publications

(53 citation statements)

References 40 publications

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“…[14][15][16] Thereinto, amphiphilic copolymers micellar carriers with hydrophobic inner core has been widely investigated during the last two decades. [17][18] For pharmaceutical applications, biodegradable and biocompatible amphiphilic copolymers are usually used to prepare micelles with relatively high stability because of their low critical micelle concentration (CMC) values. [19][20][21] Commonly, poly(ethylene glycol) (PEG) is selected as the hydrophilic segment.…”

Section: Introductionmentioning

confidence: 99%

Micelles Based on Methoxy Poly(Ethylene Glycol)Cholesterol Conjugate for Controlled and Targeted Drug Delivery of a Poorly Water Soluble Drug

He²,

Yu³

et al. 2012

Journal of Biomedical Nanotechnology

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In this study, quercetin (QC) with cancer chemoprevention effect and anticancer potential was loaded into polymeric micelles of methoxy poly(ethylene glycol)-cholesterol conjugate (mPEG-Chol) in order to increase its water solubility. MPEG-Chol with lower critical micelle concentration (CMC) value (4 0 × 10 −7 M ∼ 13 × 10 −7 M) was firstly synthesized involving two steps of chemical modification on cholesterol by esterification, and then QC was incorporated into mPEG-Chol micelles by self-assembly method. After the process parameters were optimized, QC-loaded micelles had higher drug loading (3.66%) and entrapment efficiency (93.51%) and nano-sized diameter (116 nm). DSC analysis demonstrated that QC had been incorporated non-covalently into the micelles and existed as an amorphous state or a solid solution in the polymeric matrix. The freeze-dried formulation with addition of 1% (w/v) mannitol as cryoprotectant was successfully developed for the long-term storage of QC-loaded micelles. Compared to free QC, QC-loaded micelles could release QC more slowly. Moreover, the release of QC from micelles was slightly faster in PBS at pH 5 than that in PBS at pH 7.4, which implied that QC-loaded micelles might be pH-sensitive and thereby selectively deliver QC to tumor tissue with unwanted side effects. Therefore, mPEG-Chol was a promising micellar vector for the controlled and targeted drug delivery of QC to tumor and QCloaded micelles were also worth being further investigated as a potential formulation for cancer chemoprevention and treatment.

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Section: Introductionmentioning

confidence: 99%

Micelles Based on Methoxy Poly(Ethylene Glycol)Cholesterol Conjugate for Controlled and Targeted Drug Delivery of a Poorly Water Soluble Drug

He²,

Yu³

et al. 2012

Journal of Biomedical Nanotechnology

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“…Such materials also could be used to deliver poorly water-soluble drugs after selfassembly. 43 In addition, the cationic reaction could also be carried out in ionic liquids due to the low solubility of cellulose in water. Abbott and coworkers functionalized cellulose using a chlorocholine chloride.…”

Section: Other Natural Cationic Polymersmentioning

confidence: 99%

Natural Cationic Polymers for Advanced Gene and Drug Delivery

Dai

2014

Cationic Polymers in Regenerative Medicine

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Gene and drug delivery is becoming more and more important in the treatment of complicated human diseases. Proper gene/drug delivery systems can effectively enhance therapeutic efficiency and minimize various side-effects. To date, a variety of delivery systems have been developed. Different from synthetic materials, natural polymers are abundant in nature, renewable, non-toxic, biocompatible and biodegradable. Owing to the presence of positive charges, natural cationic polymers have found important applications in many biological fields, such as drug/gene delivery and tissue engineering. In gene delivery, natural cationic polymers can condense nucleic acids, protect them from degradation, lower the immunogenicity and improve overall transfection efficiency. In drug delivery, cationic functional groups can alter the amphiphilic properties of the polymers to ensure their suitable applications for delivering hydrophobic or protein drugs. After simple chemical modification, the derivatives of natural cationic polymers show improved performance as functional delivery carriers. In this chapter, details on the chemical modification of natural cationic polymers and their applications in gene/drug delivery is discussed.

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“…This negative aspect of derivative synthesis is due to the strong intra-and intermolecular hydrogen bonding of cellulose molecules. In spite of this disadvantage, several cationic derivatives of cellulose have been prepared and analyzed for medical application, such as the self-assembling micelles based on hydrophobically modified quaternized cellulose (HMQC) for the delivery of poorly water-soluble drugs, 39 as well as derivatives with short quaternized poly[2-(N,N-dimethylamino)ethyl methacrylate] (PDMAEMA; see below) 40 or poly(ethylene oxide) (PEO) 41 polymer chains grafted onto the cellulose backbone for enhanced cationic character of the biopolymer.…”

Section: Cationic Cellulosementioning

confidence: 99%

Functionalization of Cationic Polymers for Drug Delivery Applications

Tabujew

Peneva

2014

Cationic Polymers in Regenerative Medicine

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Cationic polymers have attracted tremendous attention in recent years as non-viral vectors in gene delivery, owing to their high cellular uptake efficiency, good water solubility, excellent transfection efficiencies and facile synthesis. These polymers also show great potential for drug delivery applications, as their structure can be easily tailored to meet our growing understanding of the biological processes that govern biodistribution and biocompatibility of the carrier molecules. The incorporation of peptides, dyes or drug molecules into polymeric macromolecules has led to a synergistic combination of properties, improving the effectiveness of cationic polymers in biological applications even further. The numerous functionalization strategies, which have been developed in order to achieve this goal, are the centre of attention of this chapter. We focus on the most prominent cationic polymers and types of modification that have found applications in drug delivery, rather than trying to include all existing examples. We also describe the intrinsic functional groups of cationic polymers, which are available for further derivatization, as well as the conjugation chemistry that can be applied for the attachment of therapeutic molecules.

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Self-assembled micelles based on hydrophobically modified quaternized cellulose for drug delivery

Cited by 111 publications

References 40 publications

Micelles Based on Methoxy Poly(Ethylene Glycol)Cholesterol Conjugate for Controlled and Targeted Drug Delivery of a Poorly Water Soluble Drug

Micelles Based on Methoxy Poly(Ethylene Glycol)Cholesterol Conjugate for Controlled and Targeted Drug Delivery of a Poorly Water Soluble Drug

Natural Cationic Polymers for Advanced Gene and Drug Delivery

Functionalization of Cationic Polymers for Drug Delivery Applications

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