Self-assembled micelles prepared from bio-based hydroxypropyl methyl cellulose and polylactide amphiphilic block copolymers for anti-tumor drug release

Lu, Aijing; Petit, Eddy; Jelonek, Katarzyna; Orchel, Arkadiusz; Kasperczyk, Janusz; Wang, Yuandou; Su, Feng; Li, Suming

doi:10.1016/j.ijbiomac.2020.03.094

Cited by 33 publications

(31 citation statements)

References 31 publications

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“…28 While the hydrophilic mPEG block inhibited pyrinezolid elimination by RES, and increasing its stability and retention time in the body, 109,110 the hydrophobic block PLLA had good biocompatibility and degradability. 111 The pyrinezolid micelles were 57.8 ± 0.8 nm with a polydispersity index (PDI) of 0.68 ± 0.019 and an entrapment efficiency of 89.76 ± 3.19%. In vivo experiments showed that the oral bioavailability of pyrinezolid-micelles was 99.7%, significantly higher than that of free pyrinezolid (75.8%).…”

Section: Polymeric Micellementioning

confidence: 99%

<p>Recent Advances in Oral Nano-Antibiotics for Bacterial Infection Therapy</p>

Wu¹,

Zhao²,

Xu³

2020

IJN

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Bacterial infections are the main infectious diseases and cause of death worldwide. Antibiotics are used to treat various infections ranging from minor to life-threatening ones. The dominant route to administer antibiotics is through oral delivery and subsequent gastrointestinal tract (GIT) absorption. However, the delivery efficiency is limited by many factors such as low drug solubility and/or permeability, gastrointestinal instability, and low antibacterial activity. Nanotechnology has emerged as a novel and efficient tool for targeting drug delivery, and a number of promising nanotherapeutic strategies have been widely explored to overcome these obstacles. In this review, we explore published studies to provide a comprehensive understanding of the recent progress in the area of orally deliverable nanoantibiotic formulations. The first part of this article discusses the functions and underlying mechanisms by which nanomedicines increase the oral absorption of antibiotics. The second part focuses on the classification of oral nano-antibiotics and summarizes the advantages, disadvantages and applications of nanoformulations including lipid, polymer, nanosuspension, carbon nanotubes and mesoporous silica nanoparticles in oral delivery of antibiotics. Lastly, the challenges and future perspective of oral nano-antibiotics for infection disease therapy are discussed. Overall, nanomedicines designed for oral drug delivery system have demonstrated the potential for the improvement and optimization of currently available antibiotic therapies.

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Section: Polymeric Micellementioning

confidence: 99%

<p>Recent Advances in Oral Nano-Antibiotics for Bacterial Infection Therapy</p>

Wu¹,

Zhao²,

Xu³

2020

IJN

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“…In addition to nanoprecipitation and emulsification, there are other less used methodologies, such as mechanical treatments [ 174 , 175 , 176 , 177 ], chemical and/or enzymatic treatments [ 178 , 179 , 180 , 181 , 182 ], self-assembly processes [ 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 ], and layer-by-layer assembly [ 183 ], which can be applied (individually or in combination) to manufacture cellulose-based nanoparticles ( Table 6 ).…”

Section: Production Of Spherical Cellulose-based Nanoparticlesmentioning

confidence: 99%

Spherical Cellulose Micro and Nanoparticles: A Review of Recent Developments and Applications

et al. 2021

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Cellulose, the most abundant natural polymer, is a versatile polysaccharide that is being exploited to manufacture innovative blends, composites, and hybrid materials in the form of membranes, films, coatings, hydrogels, and foams, as well as particles at the micro and nano scales. The application fields of cellulose micro and nanoparticles run the gamut from medicine, biology, and environment to electronics and energy. In fact, the number of studies dealing with sphere-shaped micro and nanoparticles based exclusively on cellulose (or its derivatives) or cellulose in combination with other molecules and macromolecules has been steadily increasing in the last five years. Hence, there is a clear need for an up-to-date narrative that gathers the latest advances on this research topic. So, the aim of this review is to portray some of the most recent and relevant developments on the use of cellulose to produce spherical micro- and nano-sized particles. An attempt was made to illustrate the present state of affairs in terms of the go-to strategies (e.g., emulsification processes, nanoprecipitation, microfluidics, and other assembly approaches) for the generation of sphere-shaped particles of cellulose and derivatives thereof. A concise description of the application fields of these cellulose-based spherical micro and nanoparticles is also presented.

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“…Curcumin release from PEOz-PDLLA micelles was studied under in vitro conditions according to literature method. 29,30…”

Section: Drug Release Studiesmentioning

confidence: 99%

Biocompatibility, drug release, and anti‐tumor effect of pH‐sensitive micelles prepared from poly(2‐ethyl‐2‐oxazoline)‐poly(DL‐lactide) block copolymers

Wang

Zhang

Shen

et al. 2021

Polymers for Advanced Techs

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Various ratios PEOz-PDLLA diblock copolymers were synthesized through ringopening polymerization of DL-lactide initiated by monohydroxyl terminated poly (2-ethyl-2-oxazoline) (PEOz-OH). The chemical composition and molar mass of the resulting copolymers were determined by using NMR and GPC. Spherical micelles with a diameter from 104 to 136 nm were obtained via self-assembly of PEOz-PDLLA in water, as evidenced by TEM and DLS. The CMC of copolymers was well below 0.01 mg/mL, and showed a decreasing trend with increase of PDLLA block length. A two-step procedure was applied to encapsulate curcumin taken as a hydrophobic model drug. Copolymers with longer PDLLA block exhibit enhanced drug loading capacity. In vitro drug release was carried out in phosphate buffered saline (PBS) at physiological and slightly acidic pH values. A pH-sensitive biphasic drug release behavior was detected with an initial burst release followed by slower prolonged release. Lower pH or shorter PDLLA block length leads to higher drug release rate because of faster degradation of micelles. Hemo-and cytocompatibility studies illustrated the excellent biocompatibility of PEOz-PDLLA micelles. MTT assay showed a significant cytotoxicity of curcumin-loaded micelles against A549 lung cancer cells. Therefore, it can be inferred that PEOz-PDLLA block copolymers with outstanding biocompatibility, controllable drug loading performance, and prolonged drug release present a good potential as nano-carrier of hydrophobic drugs.

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Self-assembled micelles prepared from bio-based hydroxypropyl methyl cellulose and polylactide amphiphilic block copolymers for anti-tumor drug release

Cited by 33 publications

References 31 publications

<p>Recent Advances in Oral Nano-Antibiotics for Bacterial Infection Therapy</p>

<p>Recent Advances in Oral Nano-Antibiotics for Bacterial Infection Therapy</p>

Spherical Cellulose Micro and Nanoparticles: A Review of Recent Developments and Applications

Biocompatibility, drug release, and anti‐tumor effect of pH‐sensitive micelles prepared from poly(2‐ethyl‐2‐oxazoline)‐poly(DL‐lactide) block copolymers

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