Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

Li, Qiao; Lianghao, Yuan; Shijie, Gao; Zhiyi, Wang; Yuanting, Tang; Cong, Chen; Chun-Qin, Zhao; Xianjun, Fu

doi:10.1039/d3bm01451g

Biomater. Sci.

2024

DOI: 10.1039/d3bm01451g

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Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

Qiao Li,

Yuan Lianghao,

Gao Shijie

et al.

Abstract: Traditional Chinese medicine (TCM) are combinations of raw herbs and herbal extracts with a plethora of documented beneficial bioactivities, which have unique advantages in anti-tumor, and many of the major...

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Cited by 11 publications

References 215 publications

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Accessible and Effective Nanomedicines: Self‐Assembly Products From Chinese Herbal Medicines (CHMs)

Wang,

Mu,

Zhang

et al. 2024

Adv Funct Materials

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The emergence of nanotechnology has significantly promoted the development of the medical field, and the development of nanomedicines has broadened the application potential of existing drugs. However, at present, many new types of nanomedicines suffer from poor stability, uncertain safety, complex preparation processes, and high costs. The development of nano‐ Chinese herbal medicines (CHMs) has provided new ideas for the application of nanomedicines. Nano‐CHMs are simple to prepare, easily accessible, and possess stable and reliable safety. This review highlighted nanoparticles with pharmacological activities are the important material basis for CHM formula decoctions. Given the complex composition of CHM formulas, the article further presented the nanoaggregates and exosome‐like vesicle nanostructures in single herbs, and self‐assembly effect of natural compounds. For the first time, this article systematically introduced the composition and characteristics of nanoparticles from CHM formulas to single herbs and then to natural compounds, from nano‐aggregates with unclear components to exosome‐like vesicle structures and then to self‐assembled structures of supramolecular materials. It also summarized the problems to be solved in the research of CHMs nanoparticles and the potential for further applications, aiming to provide guidance for the modernization of CHMs ‐related nanoparticles.

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Accessible and Effective Nanomedicines: Self‐Assembly Products From Chinese Herbal Medicines (CHMs)

Wang,

Mu,

Zhang

et al. 2024

Adv Funct Materials

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Self‐Assembled Metal Complexes in Biomedical Research

Wang,

Xu,

Tang

et al. 2024

Advanced Materials

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Cisplatin is widely used in clinical cancer treatment; however, its application is often hindered by severe side effects, particularly inherent or acquired resistance of target cells. To address these challenges, an effective strategy is to modify the metal core of the complex and introduce alternative coordination modes or valence states, leading to the development of a series of metal complexes, such as platinum (IV) prodrugs and cyclometalated complexes. Recent advances in nanotechnology have facilitated the development of multifunctional nanomaterials that can selectively deliver drugs to tumor cells, thereby overcoming the pharmacological limitations of metal‐based drugs. This review first explores the self‐assembly of metal complexes into spherical, linear, and irregular nanoparticles in the context of biomedical applications. The mechanisms underlying the self‐assembly of metal complexes into nanoparticles are subsequently analyzed, followed by a discussion of their applications in biomedical fields, including detection, imaging, and antitumor research.

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Rational formulation of saponin and dexamethasone for the synergistic treatment of rheumatoid arthritis in vivo

Yue,

Liao,

Zhou

et al. 2024

Applied Materials Today

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Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

Abstract: Traditional Chinese medicine (TCM) are combinations of raw herbs and herbal extracts with a plethora of documented beneficial bioactivities, which have unique advantages in anti-tumor, and many of the major...

Cited by 11 publications

References 215 publications

Accessible and Effective Nanomedicines: Self‐Assembly Products From Chinese Herbal Medicines (CHMs)

Accessible and Effective Nanomedicines: Self‐Assembly Products From Chinese Herbal Medicines (CHMs)

Self‐Assembled Metal Complexes in Biomedical Research

Rational formulation of saponin and dexamethasone for the synergistic treatment of rheumatoid arthritis in vivo

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