Self-assembled Nanomaterials Type Layered Double Hydroxides Antibiotics Used as Drug Delivery Vectors

Abstract

Due to their biocompatibility, nanomaterials type layered double hydroxides (LDHs) development has attracted many researchers attention especially in medical area using them as drug delivery vectors. Their efficiency is due to the drug controlled release from the interlayer space of LDHs matrices. The controlled drug delivery characteristic is due to the reduction of drug concentration variations and maintains the desired level of drug concentration for long time. Furthermore, this action limits adverse effects and reduces the therapy duration, enhancing bactericidal activity and leading to an effective treatment. This work highlights the synthesis and characterization of hybrid structures type LDHs- tobramycin having application as antibacterial factor against Pseudomonas aeruginosa. The obtained self-assembled structures were morphologically characterized in order to point out the drug-interlayered products. Results indicate superior properties of MgAlLDHs and ZnAlLDHs behaving as host for a wide variety of molecules generally and, in our case, for tobramycin as guest.

Direct contact, dissolution and generation of reactive oxygen species: How to optimize the antibacterial effects of layered double hydroxides

“…2). In particular, special investigations were conducted to study the dissolution of antibacterial molecules-loaded LDHs to provide a controlled release of bioactive compounds [29][30][31]89,90].…”

Ceftriaxone Intercalated Nanostructures Used to Improve Medical Treatment

“…Intercalation of this antibiotic into LDHs structure ( fig. 1) improves antimicrobial treatment by increasing intracellular delivery thus reducing toxic side effects [17][18][19][20][21][22][23][24][25][26][27][28].…”

Antibiotic Encapsulated Nanomaterials with Application in Medical Area

“…A particular property of LDHs nanostructures is their ability to encapsulate large molecules as antibiotics which inhibits pathogen proliferation [10][11][12][13].…”

“…Amoxicillin is a hydrophilic drug which appertains to penicillin group of antibiotics used to treat various types of bacterial infections [12]. Similar studies were carried out in literature [13][14][15][16][17][18][19][20][21] It is considered that clavulanic acid (CA) is a feasible inhibitor of β-lactamases that hydrolyze β-lactam antibiotics and lower their efficiency [22,23].…”