Self-Assembled Nanoparticles of Dextrin Substituted with Hexadecanethiol

Gonçalves, Catarina; Martins, José A.; Gama, Miguel

doi:10.1021/bm060993e

Cited by 61 publications

(107 citation statements)

References 12 publications

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“…Dextrin-VA-SC 16 (dexC 16 ) was synthesized as comprehensively described previously [9]. DexC 16 is composed by a hydrophilic dextrin backbone with grafted acrylate groups (VA-vinyl acrylate), which are partially substituted with long alkyl chains (SC 16 ).…”

Section: Methodsmentioning

confidence: 99%

“…The dispersion was then filtrated through a 0.22 μm syringe filter. The polymer concentration must be higher than 0.008 mg/mL, previously identified as the critical micelle concentration (cmc) [9] required for the amphiphilic polymer to self-assemble in water, originating nanostructures containing hydrophobic domains, allowing the solubilization of hydrophobic molecules.…”

Section: Nanogel Preparationmentioning

confidence: 99%

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Self-Assembled Dextrin Nanogel as Curcumin Delivery System

Gonçalves¹

2012

JBNB

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Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties. Its therapeutic potential is substantially hindered by the rather low water solubility and bioavailability, hence the need for suitable carriers. In this study, we show that self-assembled nanogels obtained from hydrophobically modified dextrin are effective curcumin nanocarriers. The stability and loading efficiency of curcumin-loaded nanogel depends on the nanogel/curcumin ratio. Higher stability of the formulation is achieved in water than in PBS buffer, as evaluated by dynamic light scattering and fluorescence measurements. The in vitro release profile, using sink conditions, indicates that dextrin nanogel may perform as a suitable carrier for the controlled release of curcumin. Biological activity of curcumin-loaded nanogel in HeLa cell cultures was assessed using the MTS assay.

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Section: Methodsmentioning

confidence: 99%

Section: Nanogel Preparationmentioning

confidence: 99%

Self-Assembled Dextrin Nanogel as Curcumin Delivery System

Gonçalves¹

2012

JBNB

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“…The developed system was found to be favorable for pH-sensitive controlled delivery of curcumin and for cytotoxicity against human cervical cancer cell lines. Furthermore, Gonçalves et al [154,155] prepared a self-assembled nanogel obtained from hydrophobically modified dextrin as an effective curcumin nanocarrier. The in vitro release studies indicated the dextrin nanogel as a suitable carrier for the effective controlled release of curcumin.…”

Section: Herbal Drug Delivery Systems Against Cervical Cancermentioning

confidence: 99%

Possible role of nanocarriers in drug delivery against cervical cancer

Gupta

2017

Nano Reviews & Experiments

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Introduction: Cervical cancer is the second most common cancer and the largest cancer killer among women in most developing countries including India. Although, various drugs have been developed for cervical cancer, treatment with these drugs often results in a number of undesirable side effects, toxicity and multidrug resistance (MDR). Also, the outcomes for cervical cancer patients remain poor after surgery and chemo radiation. Methods: A literature search (for drugs and delivery systems against cervical cancer) was performed on PubMed and through Google. The present review discuss about various methods including its current conventional treatment with special reference to recent advances in delivery systems encapsulating various anticancer drugs and natural plant products for targeting towards cervical cancer. The role of photothermal therapy, gene therapy and radiation therapy against cervical cancer is also discussed. Results: Systemic/targeted drug delivery systems including liposomes, nanoparticles, hydrogels, dendrimers etc. and localized drug delivery systems like cervical patches, films, rings etc. are safer than the conventional chemotherapy which has further been proved by the several drug delivery systems undergoing clinical trials. Conclusion: Novel approaches for the aggressive treatment of cervical cancer will optimistically result in decreased side effects as well as toxicity, frequency of administration of existing drugs, to overcome MDR and to increase the survival rates.

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“…Dextrin is biocompatible and a low molecular weight carbohydrate [36]. Therefore, it can undergo renal clearance avoiding tissue accumulation [37,38] and has potential carriers for drug targeting [39]. Figure 1a shows a TEM image of dextrin-coated IFNPs.…”

Section: Physical and Magnetic Characterizationsmentioning

confidence: 99%

Synthesis, characterization, in vitro and in vivo studies of dextrin-coated zinc-iron ferrite nanoparticles (Zn0.5Fe0.5Fe2O4) as contrast agent in MRI

et al. 2015

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Iron oxide nanoparticles, such as ferrites, offer some attractive possibilities in biomedicine, especially in MRI applications. The objective of this study is to investigate the effectiveness of dextrin-coated zinc-iron ferrite nanoparticles (IFNPs) as an MRI contrast agent in in vivo and in vitro media. IFNPs were synthesized by an aqueous precipitation method in the presence of dextrin. An agarose phantom with different concentrations of dextrin-coated IFNPs was performed on a 1.5-T MRI. For in vivo MRI studies, implanted melanoma tumors in mice were immediately scanned after intra-tumoral injection of dextrincoated IFNPs. Microscopic studies showed that the average diameter of dextrin-coated IFNPs was 12 ± 2.4 nm and the saturation magnetization for IFNPs was 31.5 emu g -1 ; r 1 and r 2 relaxivities of these ultrasmall superparamagnetic IFNPs in agarose phantom were obtained as 0.99 and 17.4 mmol L -1 s -1 , respectively. The relaxivity measurements revealed that the dextrin-coated IFNPs can serve as a negative contrast agent. In vivo MRI showed that the dextrin-coated IFNPs can be used for tumor detection. The dextrin-coated IFNPs were suggested to be applied for lymph node and targeted imaging.

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Self-Assembled Nanoparticles of Dextrin Substituted with Hexadecanethiol

Cited by 61 publications

References 12 publications

Self-Assembled Dextrin Nanogel as Curcumin Delivery System

Self-Assembled Dextrin Nanogel as Curcumin Delivery System

Possible role of nanocarriers in drug delivery against cervical cancer

Synthesis, characterization, in vitro and in vivo studies of dextrin-coated zinc-iron ferrite nanoparticles (Zn0.5Fe0.5Fe2O4) as contrast agent in MRI

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