Self-assembled nanoreactors based on peptides and proteins

Timmermans, Suzanne B. P. E.; Hest, Jan C. M. van

doi:10.1016/j.cocis.2018.01.005

Cited by 28 publications

(33 citation statements)

References 80 publications

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“…[1][2][3] Using various supramolecular catalysts, catalytic reactions including hydrogenation, [4,5] oxidation, [6][7][8] and the aldol reaction [9][10][11] have been explored under mild conditions, which is beneficial for decreasing the energy consumption of these processes. [1][2][3] Using various supramolecular catalysts, catalytic reactions including hydrogenation, [4,5] oxidation, [6][7][8] and the aldol reaction [9][10][11] have been explored under mild conditions, which is beneficial for decreasing the energy consumption of these processes.…”

Section: Introductionmentioning

confidence: 99%

Copper‐Coordinated Histidyl Bolaamphiphile Assembly as an Oxidative Catalyst: Coordination Structure and Catalytic Activity in Cyclohexane Oxidation

et al. 2019

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Surface‐exposed imidazole moieties of a supramolecular self‐assembly of histidyl bolaamphiphile (HisC7) readily coordinate at transition metal ions. In this study, the Cu‐coordinated histidyl bolaamphiphile assembly (HisC7[Cu]) is demonstrated to be an effective oxidative catalyst, with a Fenton‐active copper center. HisC7[Cu] catalytically oxidized cyclohexane to produce cyclohexanol in the yield of 20.2 %, which is comparable to other homogeneous catalysts. The coordination sphere of the active copper center is investigated through various spectroscopic techniques in consideration of the catalytic activity. The highest catalytic activity is exhibited by the HisC7[Cu] catalyst prepared at a HisC7/Cu molar ratio of 0.75, where the copper center of HisC7[Cu] has a 1N3O coordination environment. The copper center with bidentate coordination to imidazole groups shows low activity due to the lack of open coordination sites. The HisC7[Cu] catalyst is applied to the oxidation of cyclohexane, and the reaction characteristics and reusability of HisC7[Cu] are studied.

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Section: Introductionmentioning

confidence: 99%

Copper‐Coordinated Histidyl Bolaamphiphile Assembly as an Oxidative Catalyst: Coordination Structure and Catalytic Activity in Cyclohexane Oxidation

et al. 2019

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“…The assembly of supramolecular structures for biotechnological applications has gained momentum within the last years . Controlling and understanding the self‐assembly of supramolecular structures is of great importance for fundamental and applied science such as biomedicine and biotechnology . The autonomous organization of components based on their shape, surface properties, charge, etc., into hierarchical patterns and architectures without human intervention can be defined as self‐assembly .…”

Section: Introductionmentioning

confidence: 99%

“…Even though individual interactions are generally weak, collectively they can create very stable structures . Amphiphilic protein‐based building blocks have been assembled into different supramolecular structures such as micelles, fibers, sheets, and vesicles and used as reaction chamber in biotechnology or drug delivery . Often the assembled structures or involved protocols lack assembly control, biocompatibility, or encapsulation efficiency .…”

Section: Introductionmentioning

confidence: 99%

Self‐Assembly Toolbox of Tailored Supramolecular Architectures Based on an Amphiphilic Protein Library

Schreiber

Stühn

Huber

et al. 2019

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The molecular structuring of complex architectures and the enclosure of space are essential requirements for technical and living systems. Self‐assembly of supramolecular structures with desired shape, size, and stability remains challenging since it requires precise regulation of physicochemical and conformational properties of the components. Here a general platform for controlled self‐assembly of tailored amphiphilic elastin‐like proteins into desired supramolecular protein assemblies ranging from spherical coacervates over molecularly defined twisted fibers to stable unilamellar vesicles is introduced. The described assembly protocols efficiently yield protein membrane–based compartments (PMBC) with adjustable size, stability, and net surface charge. PMBCs demonstrate membrane fusion and phase separation behavior and are able to encapsulate structurally and chemically diverse cargo molecules ranging from small molecules to naturally folded proteins. The ability to engineer tailored supramolecular architectures with defined fusion behavior, tunable properties, and encapsulated cargo paves the road for novel drug delivery systems, the design of artificial cells, and confined catalytic nanofactories.

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“…The scaffold of gel can be formed by various of gelators, among which, peptides are a kind of rising materials for the fabrication of gels because of their biocompatibility and their molecule structures can be rationally designed . Large numbers of peptide gels have been reported for the functions of tissue engineering, nanoreactors, drug delivery vehicle, antibacterial agent and regenerative medicine . Phenylalanine‐phenylalanine (FF) dipeptide is usually used as the core recognition of the β‐amyloid fiber and may be the simplest peptide with kinds of self‐assembled structures driven by the π‐π stacking interaction between the benzene rings .…”

Section: Introductionmentioning

confidence: 99%

The Investigation of a Multi‐Functional Peptide as Gelator, Dyes Separation Agent and Metal Ions Adsorbent

Cui

Zhang

et al. 2019

ChemistrySelect

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A multi‐functional peptide molecule was rational designed to use as gelator, dyes separation agent and metal ions adsorbent. The peptide molecule consists of phenylalanine‐phenylalanine‐alanine‐cysteine‐aspartic acid with a protective group of acetyl, simplified as Ac‐FFACD‐OH. FF is the critical composition of gelator and contributes to the formation of gels in a range of pH values from 1.0 to 6.0. The application as drug delivery system (DDS) of gels was tested by encapsulating DOX without destroying the gel structure. The in vitro release behaviors were investigated at different pH, showing a rapid release at pH 5.5 while a slow release at pH 7.4. Among all the amino acids, D is one of the only two acidic amino acids, which can bring acidity and electronegativity to peptide molecules. The electrostatic attraction makes the peptide to be a good adsorption agent for cationic dyes and repulsive towards anionic dyes. Adsorption experiments show that the adsorption efficiency is higher than 90% for cationic dyes and lower than 25% for anionic dyes. In a separation experiment, about 60% of the anionic dyes can be separated from the mixed dyes. Metal ions are also adsorbed with high adsorption efficiency of > 99% for Fe3+ and > 95% for Cu2+. The multi‐functions of the peptide molecule will provide theoretical basis and practical application for the goal‐directed design of peptide molecule structures.

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Self-assembled nanoreactors based on peptides and proteins

Cited by 28 publications

References 80 publications

Copper‐Coordinated Histidyl Bolaamphiphile Assembly as an Oxidative Catalyst: Coordination Structure and Catalytic Activity in Cyclohexane Oxidation

Copper‐Coordinated Histidyl Bolaamphiphile Assembly as an Oxidative Catalyst: Coordination Structure and Catalytic Activity in Cyclohexane Oxidation

Self‐Assembly Toolbox of Tailored Supramolecular Architectures Based on an Amphiphilic Protein Library

The Investigation of a Multi‐Functional Peptide as Gelator, Dyes Separation Agent and Metal Ions Adsorbent

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