Self-assembled peptide microspheres for sustainable release of sulfamethoxazole

Abstract

Porous peptide microspheres have been used for the loading and sustained release of the bacteriostatic antibiotic sulfamethoxazole.

Amphiphilic polypeptides with prolonged enzymatic stability for the preparation of self-assembled nanobiomaterials

“…26 The results from the molecular dynamics study of a series of Ac-(Aib) n -NHMe (where Ac, acetyl; n ¼ 5-7, 10; NHMe ¼ methylamino) were recently published as well. 27 A range of publications reported the synthesis of Aib-containing peptides via solution 22,[31][32][33] or solid-phase techniques. 21,[34][35][36][37] Recently, Tsuchiya and Numata described also the enzymatic synthesis of hydrophobic polypeptides based on Ala and Aib.…”

“…The self-assembling properties of Aib-containing peptides were the subject of many investigations. [28][29][30][31][32][39][40][41] In particular, Kimura and co-workers synthesized peptide nanotubes of different size . 40 More recently, Haldar and coworkers demonstrated that Boc-Phe-Aib-Gabu-OMe and Boc-Tyr-Aib-Gabu-OMe (Gabu, g-aminobutyric acid) are able to form polydisperse microspheres with a diameter of ca.…”

“…40 More recently, Haldar and coworkers demonstrated that Boc-Phe-Aib-Gabu-OMe and Boc-Tyr-Aib-Gabu-OMe (Gabu, g-aminobutyric acid) are able to form polydisperse microspheres with a diameter of ca. 750 nm, 32 while Boc-Leu-Aib-Ser-OMe self-assembles into supramolecular nanotubes able to encapsulate hydrophobic guests. 41 Stimulated by these ndings, we designed and synthesized amphiphilic, random and block copolypeptides of Lys and Aib as a novel biomaterial for various biological applications in drug delivery, tissue engineering, etc.…”

“… 40 More recently, Haldar and coworkers demonstrated that Boc-Phe-Aib-Gabu-OMe and Boc-Tyr-Aib-Gabu-OMe (Gabu, γ-aminobutyric acid) are able to form polydisperse microspheres with a diameter of ca. 750 nm, 32 while Boc-Leu-Aib-Ser-OMe self-assembles into supramolecular nanotubes able to encapsulate hydrophobic guests. 41 …”