Self-assembled peptide nanoparticles responsive to multiple tumor microenvironment triggers provide highly efficient targeted delivery and release of antitumor drug

Jiang, Xinglu; Fan, Xuetong; Xu, Wei; Zhao, Chenggui; Wu, Hao; Zhang, Rui; Wu, Guoqiu

doi:10.1016/j.jconrel.2019.10.031

Cited by 41 publications

(14 citation statements)

References 40 publications

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“…44 A number of studies demonstrated that the RGD modied nano-drug delivery systems could improve the active targeting efficiency of tumor cells. [45][46][47][48] Thereby, the ultrasound irritation could mediate the drug-loaded NBs to be more easily internalized into the cells, and the prepared RGD-modied NBs could further improve cellular uptake and increase the delivery efficiency of FTY720. The cellular uptake efficiency of the FTY720@SPION/PFP/NB or FTY720@SPION/PFP/RGD-NB was also evaluated by observing MRI T2-weighted imaging (T2WI) and by measuring T 2 value of HepG2 cells when incubated with different nanoparticles using a clinical 1.5T MRI scanner.…”

Section: Resultsmentioning

confidence: 99%

Ultrasound-mediated delivery of RGD-conjugated nanobubbles loaded with fingolimod and superparamagnetic iron oxide nanoparticles: targeting hepatocellular carcinoma and enhancing magnetic resonance imaging

et al. 2020

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Section: Resultsmentioning

confidence: 99%

Ultrasound-mediated delivery of RGD-conjugated nanobubbles loaded with fingolimod and superparamagnetic iron oxide nanoparticles: targeting hepatocellular carcinoma and enhancing magnetic resonance imaging

et al. 2020

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“…In addition, many other chemotherapeutics-derived nanoDDS, for example gemcitabine (GEM) 77 , 78 , coumarin 6 27 , trichosanthin 79 , methotrexate (MTX) 80 , pirfenidone 81 , pirarubicin 82 , cabazitaxel 83 , and SN38 84 , have also made extensive biomedical advances as stand-alone or multidrug combinations.…”

Section: Protease-responsive Nanodds For the Targeted Theranostics Of Malignancymentioning

confidence: 99%

“…DOX-encapsulated gold nanoclusters were presented for computed tomography (CT) imaging-visualized cancer chemotherapy 123 . The above MMP-2-encouraged representative achievements in cancer theranostics are summarized in Table 2 23 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 ...…”

Section: Protease-responsive Nanodds For the Targeted Theranostics Of Malignancymentioning

confidence: 99%

Protease-triggered bioresponsive drug delivery for the targeted theranostics of malignancy

Zhang

Guo

et al. 2021

Acta Pharmaceutica Sinica B

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Proteases have a fundamental role in maintaining physiological homeostasis, but their dysregulation results in severe activity imbalance and pathological conditions, including cancer onset, progression, invasion, and metastasis. This striking importance plus superior biological recognition and catalytic performance of proteases, combining with the excellent physicochemical characteristics of nanomaterials, results in enzyme-activated nano-drug delivery systems (nanoDDS) that perform theranostic functions in highly specific response to the tumor phenotype stimulus. In the tutorial review, the key advances of protease-responsive nanoDDS in the specific diagnosis and targeted treatment for malignancies are emphatically classified according to the effector biomolecule types, on the premise of summarizing the structure and function of each protease. Subsequently, the incomplete matching and recognition between enzyme and substrate, structural design complexity, volume production, and toxicological issues related to the nanocomposites are highlighted to clarify the direction of efforts in nanotheranostics. This will facilitate the promotion of nanotechnology in the management of malignant tumors.

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“…The multiple endogenous sensitive smart materials were common in many works, such as dual responsive materials to pH and GSH, 273–277 pH and hypoxia, 131 pH and enzyme, 173 ROS and GSH, 60,278,279 GSH and hypoxia, 280,281 as well as GSH and enzyme 183 . There were also examples of triple responsive materials which were sensitive to pH, GSH, and enzyme 161,282 …”

Section: Multiple‐triggered Smart Materialsmentioning

confidence: 99%

Smart materials for drug delivery and cancer therapy

Yang

Zeng

Huang

et al. 2020

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127

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Until now, enormous smart materials have been engineered with endogenous stimulators such as pH, reactive oxygen species, glutathione, hypoxia and enzyme, or exogenous stimulators such as temperature, light, ultrasound, radiation, and magnetic field in drug delivery. As footstone of stimuli‐responsive nanocarriers, endogenous/exogenous responsive smart materials possess many properties, such as responding ability to specific triggers, controlled drug release, long blood circulation, increased tumor accumulation, “ON‐OFF” switch activities, enhanced diagnostic accuracy, and therapeutic efficacy. Smart materials have attracted considerable attention because they provide likelihood strategy for individualized and comprehensive therapy. In this review, significant research achievements of smart materials responsive to different triggers including their synthesis and formulation mechanism, responsive mechanism, applications, multiple functions are summarized and discussed separately. We primarily focus on the studies in the past few years (2017‐2020). The current situation and remaining challenges of stimuli‐sensitive materials‐based nanocarriers for clinical translation are discussed rationally at the end. It is hope that this timely and overall review would provide some helpful information for researchers in this field.

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Self-assembled peptide nanoparticles responsive to multiple tumor microenvironment triggers provide highly efficient targeted delivery and release of antitumor drug

Cited by 41 publications

References 40 publications

Ultrasound-mediated delivery of RGD-conjugated nanobubbles loaded with fingolimod and superparamagnetic iron oxide nanoparticles: targeting hepatocellular carcinoma and enhancing magnetic resonance imaging

Ultrasound-mediated delivery of RGD-conjugated nanobubbles loaded with fingolimod and superparamagnetic iron oxide nanoparticles: targeting hepatocellular carcinoma and enhancing magnetic resonance imaging

Protease-triggered bioresponsive drug delivery for the targeted theranostics of malignancy

Smart materials for drug delivery and cancer therapy

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