Self-Assembled Phytochemical Nanomedicines with Enhanced Bioactivities for Effective Acute Kidney Injury Therapy

Abstract

Acute kidney injury (AKI) is a common and lethal complication for inpatients in the intensive care unit. Accumulative evidence suggests that severe inflammation and oxidative stress are major causes of AKI. Natural polyphenols with potent antioxidative and anti-inflammation activities are promising in the treatment of AKI, but low bioavailability reduces their therapeutic efficacy in vivo. Herein, we reported a novel polyphenol-based nanomedicine comprising a tea polyphenol nanocarrier and the insoluble small-molecule drug curcumin for targeted sepsis-induced AKI therapy. Tea polyphenol nanoparticles (TP-NPs) were synthesized with the tea polyphenol oligomers, and then curcumin-containing nanoparticles (Cur-NPs) were prepared by the loading of curcumin into TP-NPs. In vitro experiments proved the capability of Cur-NPs to scavenge free radicals, protect normal cells from oxidative damage, and suppress the expression of proinflammatory factors. Furthermore, these polyphenol-based nanomedicines effectively alleviated septic AKI by suppressing the inflammation response and restoring oxidant-redox homeostasis in vivo. The prepared Cur-NPs further exhibited carrier-enhanced efficacy due to the therapeutic effects of inornate TP-NPs. In conclusion, the phytochemical nanomedicines provide an attractive strategy for AKI therapy and herald a prospective future in the development of natural reproducible resource-derived nanomedicines for various diseases related to oxidative stress and inflammation.

Enhanced iodine capture by the hydrogen bond reconstruction strategy

“…In the FT-IR spectrum, the hydroxyl stretching peak of the enol form in the CILs at 3500 cm −1 disappeared completely, owing to the strong acidity of hydrogen in the enol form, which undergoes a reaction during the synthesis of compounds. 45,48–50 In both CILs, a remarkable red shift from 1600 cm −1 to 1564 cm −1 could be observed definitely, which could be ascribed to the CO stretching of Cur. Additionally, the peaks at 1280 cm −1 and 1028 cm −1 were identified as symmetric stretching vibration and asymmetric stretching vibration of the methoxy group, respectively.…”

pH-Responsive Carrier-Free Polyphenol Nanoparticles Assembled by Oxidative Polymerization with Enhanced Stability and Antioxidant Activity for Improved Bioaccessibility

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Amino Acid-Modified Lignin Combined with Methylation to Form Novel pH-Responsive Colloidal Spheres with Tunable Properties

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