Self-assembled sialyllactosyl probes with aggregation-enhanced properties for ratiometric detection and blocking of influenza viruses

Small-molecule fluorescence-based probes for interrogating major organ diseases

“…Most of the fluorescent probes reported to date rely on fluorescent reporter groups that absorb and emit in the NIR I region or visible light range. 68 This limits their utility in terms of studying organ diseases. On the other hand, the development of small molecule-based fluorescent probes with higher emission wavelengths (near-infrared region II band) are expected to facilitate the development of systems suitable for monitoring deep-set organ-related diseases.…”

A glycoconjugate-based gold nanoparticle approach for the targeted treatment of Pseudomonas aeruginosa biofilms

“…DCM-loaded Fuc-AuNPs/Gal-AuNPs afforded a highly selective bacterial fluorescence imaging agent. 55 While, CAZ loaded Fuc-AuNPs/Gal-AuNPs were shown to have improved therapeutic efficacy towards P. aeruginosa when compared to CAZ alone. Exploiting the phototherapeutic properties of the AuNP core (PTT and PDT), light irradiation resulted in an enhanced therapeutic effect towards P. aeruginosa when combined with CAZ.…”

Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy

“…Throughout nature, glycoconjugates are known to selectively bind to carbohydrate receptors and modulate a variety of physiological and pathological processes. Such examples include cell-cell recognition, 37 signal transmission, 38 virus invasion 39 and bacterial infection. 40 Previous studies have reported the overexpression of mannose receptors (MRs) on the cell surface of tumor-associated macrophages (TAMs).…”