Self-assembled supramolecular hydrogels formed by biodegradable PEO–PHB–PEO triblock copolymers and α-cyclodextrin for controlled drug delivery

Li, Jun; Li, Xu; Ni, Xiping; Wang, Xin; Li, Hongzhe; Leong, Kam W.

doi:10.1016/j.biomaterials.2006.03.025

Cited by 421 publications

(377 citation statements)

References 50 publications

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“…65 PHA-polyether block copolymers were prepared via a diisocyanate chain extension reaction with hydroxyl-capped polyethers such as PEG and Poly(propylene glycol) (PPG). A series of PHB/PEG poly(ether Modified PHAs as engineering materials Z Li et al ester urethane)s block copolymers with various PHB and PEG segment lengths were synthesized.…”

Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

Polyhydroxyalkanoates: opening doors for a sustainable future

2016

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Polyhydroxyalkanoates (PHAs) comprise a group of natural biodegradable polyesters that are synthesized by microorganisms. However, several disadvantages limit their competition with traditional synthetic plastics or their application as ideal biomaterials. These disadvantages include their poor mechanical properties, high production cost, limited functionalities, incompatibility with conventional thermal processing techniques and susceptibility to thermal degradation. To circumvent these drawbacks, PHAs need to be modified to ensure improved performance in specific applications. In this review, well-established modification methods of PHAs are summarized and discussed. The improved properties of PHA that blends with natural raw materials or other biodegradable polymers, including starch, cellulose derivatives, lignin, poly(lactic acid), polycaprolactone and different PHA-type blends, are summarized. The functionalization of PHAs by chemical modification is described with respect to two important synthesis approaches: block copolymerization and graft copolymerization. The expanded utilization of the modified PHAs as engineering materials and the biomedical significance in different areas are also addressed.

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Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

Polyhydroxyalkanoates: opening doors for a sustainable future

2016

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“…Using it in medical and generally in vivo applications [5][6][7][8][9][10][11][12][13] seems to be obvious, since the polymer yields only nontoxic metabolites [14][15][16][17]. One of the most important and most intensively studied area is the use of poly(3-hydroxybutyrate) as drug carrier matrix [18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

A novel method for the determination of diffusion coefficients in amorphous poly(3-hydroxybutyrate)

et al. 2017

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“…These structures could possess the same properties of covalent crosslinked hydrogels adding new promising features such as a quick degradation process 3 , stimuli responsive properties 2 or the capability of gelling "in situ" by physical crosslinking between different molecules or subunits 1,3,5,8 .…”

Section: Introductionmentioning

confidence: 99%

“…1a) 3,5,10 . Cyclodextrins yield inclusion complexes also with PEO/PPO block copolymers yielding selective polyrotaxanes depending on the type of CD used [11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Supramolecular Gels of Reverse Poloxamers and Cyclodextrins

Larrañeta

Isasi

2012

Langmuir

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A series of supramolecular aggregates were prepared using a poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) (PPO-PEO-PPO) block copolymer and β-or α-cyclodextrins (CD). The combination of β-CD and the copolymer yields inclusion complexes (IC) with polypseudorotaxane structures. These are formed by complexation of the PPO blocks with β-CD molecules producing a powder precipitate with a certain crystallinity degree that can be evaluated by X-ray diffraction (XRD). In contrast, when combining α-CD with the block copolymer, the observed effect is an increase in the viscosity of the mixtures yielding fluid gels. Two cooperative effects come into play: the complexation of PEO blocks with α-CD and the hydrophobic interactions between PPO blocks in aqueous media. These two combined interactions lead to the formation of a macromolecular network. The resulting fluid gels were characterized using different techniques such as differential scanning calorimetry (DSC), viscometry and XRD measurements.

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Self-assembled supramolecular hydrogels formed by biodegradable PEO–PHB–PEO triblock copolymers and α-cyclodextrin for controlled drug delivery

Cited by 421 publications

References 50 publications

Polyhydroxyalkanoates: opening doors for a sustainable future

Polyhydroxyalkanoates: opening doors for a sustainable future

A novel method for the determination of diffusion coefficients in amorphous poly(3-hydroxybutyrate)

Self-Assembled Supramolecular Gels of Reverse Poloxamers and Cyclodextrins

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