2012
DOI: 10.1002/adfm.201200488
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Self‐Assembling Nanotubes Consisting of Rigid Cyclic γ‐Peptides

Abstract: Self‐assembling cyclic peptide nanotubes (SPNs) have been extensively studied due to their potential applications in biology and material sciences. Cyclic γ‐peptides, which have a larger conformational space, have received less attention than the cyclic α‐ and β‐peptides. The self‐assembly of cyclic homo‐γ‐tetrapeptide based on cis‐3‐aminocyclohexanecarboxylic acid (γ‐Ach) residues, which can be easily synthesized by a one‐pot process is investigated. Fourier transform infrared (FTIR) and NMR analysis along wi… Show more

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Cited by 35 publications
(25 citation statements)
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“…After dispersing the organogel in water by sonication, the authors were able to examine the systems by atomic force microscopy (AFM) and tunnelling electron microscopy (TEM). These two techniques were able to show that the peptides formed into long (>1 μm) regular nanofibres, with a height of 1.4–1.6 nm and a width of ∼5 nm 17d. This type of structural data from microscopy is able to provide important detail about the type of structures that can form, and the dimensions of the fibres found in this case are consistent with a structure that has individually stacked units of 1 .…”
Section: Quantum Chemistrymentioning
confidence: 63%
See 3 more Smart Citations
“…After dispersing the organogel in water by sonication, the authors were able to examine the systems by atomic force microscopy (AFM) and tunnelling electron microscopy (TEM). These two techniques were able to show that the peptides formed into long (>1 μm) regular nanofibres, with a height of 1.4–1.6 nm and a width of ∼5 nm 17d. This type of structural data from microscopy is able to provide important detail about the type of structures that can form, and the dimensions of the fibres found in this case are consistent with a structure that has individually stacked units of 1 .…”
Section: Quantum Chemistrymentioning
confidence: 63%
“…In their recent work on rigid cyclic γ‐peptides, Wu, Deng, and coworkers utilized a combination of experimental and computational methods to determine the self‐assembled structure of their peptide nanotubes 17d. In this work, the authors demonstrated that it was possible to synthesize the cyclic γ‐tetrapeptide ( 1 , Figure 5) through a cyclodimerization reaction of the parent dipeptide 17d…”
Section: Quantum Chemistrymentioning
confidence: 99%
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“…Phe-Phe, tert-butyl dicarbonate (Boc)-Phe-Phe) 7,8,[16][17][18][19][20][21] . The structures formed by these homoaromatic peptides include tubular structures, spheres, sheet-like assemblies and fibers 6,8,15,[21][22][23][24][25][26][27][28][29][30][31][32] . The fibers in some cases generate a fibril mesh that yields a hydrogel [33][34][35][36][37] .…”
Section: Introductionmentioning
confidence: 99%