Self-assembly and β-carotene loading capacity of hydroxyethyl cellulose-graft-linoleic acid nanomicelles

Yang, Yang; Guo, Yanzhu; Sun, Run‐Cang; Wang, Xiaohui

doi:10.1016/j.carbpol.2016.03.012

Cited by 67 publications

(23 citation statements)

References 44 publications

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“…Table 1). After loading with DOX, the size of the micelles increased significantly due to the solubilizing of hydrophobic treated DOX into the polymeric micelles 25,36 . The morphologies of blank and drug loaded micelles were shown in Fig.…”

Section: Synthesis and Characterization Of Fhcspbamentioning

confidence: 99%

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

et al. 2016

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Phenylboronic and folate grafted chitosan hydrochloride (FHCSPBA) was synthesized and confirmed by FTIR and 1 H NMR.Glucose and pH dually responsive micelles were obtained through self-assembling of the amphiphilic polymer. The prepared FHCSPBA micelles displayed good biocompability and sustained drug release for the model drug doxorubicin hydrochloride (DOX). The cumulative drug release from the polymeric micelles showed obvious pH and glucose dependence and was accelerated by slightly decreasing the medium pH or increasing the glucose concentration. In vitro antitumor efficiency was evaluated by incubating the DOX loaded micelles with 4T1 breast cancer cells, and the results showed that folate-targeted micelles had higher antitumor activity than the non-targeted ones. Cellular uptake demonstrated by confocal microscopy indicated that free DOX was internalized into the nuclei of 4T1 cells, while the DOX loaded micelles were internalized in the cytoplasm. The cell uptake of the micelles was enhanced by folate with stronger fluorescence intensity in the cytoplasm due to the active FR-mediated endocytosis. These folate-conjugated glucose and pH dually responsive micelles may be a potential antitumor drug delivery system for chemotherapy of cancer.The relative cytotoxicity of FHCSPBA micelles was performed by Cell Counting Kit-8 (CCK-8) assay against L929 fibroblasts. The cells were seeded onto 96-well plates at a density of 4 × 10 4 cells per well in

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Section: Synthesis and Characterization Of Fhcspbamentioning

confidence: 99%

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

et al. 2016

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“…Yang, Guo, Sun, and Wang () synthesized an HEC‐ graft ‐linoleic acid (HEC‐ g ‐LA) copolymer by coupling to develop CP micelles. The synthesis of HEC‐ g ‐LA copolymer was completed by an esterification reaction between the hydroxyl groups of HEC and carboxyl groups of LA.…”

Section: Scps In Foodmentioning

confidence: 99%

“…Yang et al. () self‐assembled β‐carotene/LA‐ graft ‐HEC NPs via sonication‐dialysis method. These authors observed self‐assembled materials with particle size between 20 and 50 nm.…”

Section: Potential Applications Of Scps In Foodmentioning

confidence: 99%

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Self‐Assembled Carbohydrate Polymers for Food Applications: A Review

Valencia

Zare‬

Makvandi

et al. 2019

Comp Rev Food Sci Food Safe

112

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The self‐assembled natural and synthetic polymers are booming. However, natural polymers obtained from native or modified carbohydrate polymers (CPs), such as celluloses, chitosan, glucans, gums, pectins, and starches, have had special attention as raw material in the manufacture of self‐assembled polymer composite materials having several forms: films, hydrogels, micelles, and particles. The easy manipulation of the architecture of the CPs, as well as their high availability in nature, low cost, and being sustainable and green polymers have been the main positive points in the use of them for different applications. CPs have been used as building blocks for composite structures, and their easy orientation and ordering has given rise to self‐assembled CPs (SCPs). These macromolecules have been little studied for food applications. Nonetheless, their research has grown mainly in the last 5 years as encapsulated food additive wall materials, food coatings, and edible films. The multifaceted properties (systems sensitive to pH, temperature, ionic strength, types of ions, mechanical force, and enzymes) of these devices are leading to the development of advanced food materials. This review article focused on the analysis of SCPs for food applications in order to encourage other research groups for their preparation and implementation.

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“…In addition, food processing and storage conditions such as high temperature, oxygen and light can also reduce the functionality of bioactive constituents. To overcome the poor stability and improve the solubility of the constituents in vivo , delivery systems such as nanoemulsion must be adopted . Nanoemulsions have many potential advantages over conventional emulsions as a result of their smaller droplet size (droplet radius < 100 nm), such as the ability to greatly increase water dispersion and bioavailability of the bioactive components and weakly scatter light, and they are highly stable to particle aggregation and gravitational separation …”

Section: Introductionmentioning

confidence: 99%

Konjac glucomannan octenyl succinate (KGOS) as an emulsifier for lipophilic bioactive nutrient encapsulation

Zhong

Meng

et al. 2018

J Sci Food Agric

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Self-assembly and β-carotene loading capacity of hydroxyethyl cellulose-graft-linoleic acid nanomicelles

Cited by 67 publications

References 44 publications

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

Self‐Assembled Carbohydrate Polymers for Food Applications: A Review

Konjac glucomannan octenyl succinate (KGOS) as an emulsifier for lipophilic bioactive nutrient encapsulation

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