Self-assembly of a robust, reduction-sensitive camptothecin nanotube

Sun, Yuan; Fry, Cathleen M; Shieh, Aileen; Parquette, Jon R.

doi:10.1039/d0cc03528a

Cited by 12 publications

(5 citation statements)

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“…Nanotubes formed by the self-assembly of peptides are remarkable anisotropic hollow nanostructures, [1][2][3][4][5][6][7][8][9] with a diversity of potential applications, for example in biocatalysis, [10][11][12][13] encapsulation/ release [14][15][16][17][18][19] and a number of biomedical uses. [20][21][22][23][24] Several distinct architectures of peptide nanotubes have been uncovered, including those based on stacked cyclic peptides with alternating D-and L-residues, 4,25,26 wrapped b-sheet structures, 11,13,[27][28][29][30][31][32][33][34][35][36] stacked peptide dimer laminate structures, 5,37,38 and coiled coil peptide assemblies.…”

Section: Introductionmentioning

confidence: 99%

Alpha helical surfactant-like peptides self-assemble into pH-dependent nanostructures

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Alpha helical surfactant-like peptides self-assemble into pH-dependent nanostructures

et al. 2021

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“…The authors also proposed that 1 resides at outer shell and 2 at the inner shell of the nanotubes, an interesting assumption that may worth the structural determination by cryo‐EM [10] . In an earlier study by Parquette et al., the authors reported a tetrapeptide (CPT‐CCKK, 3 , Scheme 1) that self‐assembles to form nanotubes for delivering CPT [11] . Specifically, the self‐assembly and oxidative crosslinking of 3 forms intermolecular disulfide bond to control the structure stability and CPT release rate.…”

Section: Assemblies Of the Conjugates Of Peptide And Drugmentioning

confidence: 99%

“…[10] In an earlier study by Parquette et al, the authors reported a tetrapeptide (CPT-CCKK, 3, Scheme 1) that self-assembles to form nanotubes for delivering CPT. [11] Specifically, the self-assembly and oxidative crosslinking of 3 forms intermolecular disul-fide bond to control the structure stability and CPT release rate. Incubated in PBS at 20 mM for 3 days, the mature nanotubes exhibited a wide range of diameters (232 � 60 nm) and lengths of several micrometers measured by transmission electron microscopy (TEM).…”

Section: Peptides Conjugated With Anticancer Drugsmentioning

confidence: 99%

Peptide Assemblies for Cancer Therapy

2023

ChemMedChem

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Supramolecular assemblies made by the self‐assembly of peptides are finding an increasing number of applications in various fields. While the early exploration of peptide assemblies centered on tissue engineering or regenerative medicine, the recent development has shown that peptide assemblies can act as supramolecular medicine for cancer therapy. This review covers the progress of applying peptide assemblies for cancer therapy, with the emphasis on the works appeared over the last five years. We start with the introduction of a few seminal works on peptide assemblies, then discuss the combination of peptide assemblies with anticancer drugs. Next, we highlight the use of enzyme‐controlled transformation or shapeshifting of peptide assemblies for inhibiting cancer cells and tumors. After that, we provide the outlook for this exciting field that promises new kind of therapeutics for cancer therapy.

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“…At present, the focus of the pharmaceutical field is to use intermolecular forces including hydrogen bonds, hydrophobic forces, and salt bonds to convert drugs, especially low-solubility drugs into nano-preparations to avoid some side effects of drugs [ 118 , 119 ]. Nanosizing, a technique for formulating drug powders into particles of nano-scale, is recognized for its ability to enhance drug absorption and enable the intravenous administration of insoluble drugs [ 120 ].…”

Section: Limitations Of Saponins As Potential Immunomodulatorsmentioning

confidence: 99%

Potential Immunoregulatory Mechanism of Plant Saponins: A Review

Shen,

Luo,

Fan

et al. 2023

Molecules

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Saponins are extracted from different parts of plants such as seeds, roots, stems, and leaves and have a variety of biological activities including immunomodulatory, anti-inflammatory effects, and hypoglycemic properties. They demonstrate inherent low immunogenicity and possess the capacity to effectively regulate both the innate and adaptive immune responses. Plant saponins can promote the growth and development of the body’s immune organs through a variety of signaling pathways, regulate the activity of a variety of immune cells, and increase the secretion of immune-related cytokines and antigen-specific antibodies, thereby exerting the role of immune activity. However, the chemical structure of plant saponins determines its certain hemolytic and cytotoxicity. With the development of science and technology, these disadvantages can be avoided or reduced by certain technical means. In recent years, there has been a significant surge in interest surrounding the investigation of plant saponins as immunomodulators. Consequently, the objective of this review is to thoroughly examine the immunomodulatory properties of plant saponins and elucidate their potential mechanisms, with the intention of offering a valuable point of reference for subsequent research and advancement within this domain.

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Self-assembly of a robust, reduction-sensitive camptothecin nanotube

Abstract: The self-assembly and covalent crosslinking of a Camptothecin (CPT) tetrapeptide nanotube is reported. Intermolecular disulfide bond formation of a self-assembled CPT-peptide reversibly stabilized the nanotubes toward dissociation at low concentrations,...

Cited by 12 publications

References 50 publications

Alpha helical surfactant-like peptides self-assemble into pH-dependent nanostructures

Alpha helical surfactant-like peptides self-assemble into pH-dependent nanostructures

Peptide Assemblies for Cancer Therapy

Potential Immunoregulatory Mechanism of Plant Saponins: A Review

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