Self-Assembly of Cyclic Dipeptides and Their Fluorescent Properties

Yang, Jingge; Li, Yang; Wang, Xiaoai; Wang, Dong; Sun, Yawei; Wang, Jiqian; Xu, Hai

doi:10.6023/a19090331

Cited by 4 publications

(2 citation statements)

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“…(1) α-helix would transform into β-sheet and random coils since the entropy was climbing [46,47]. (2) α-helix was more likely to be degraded because it located in the vulnerable amorphous region [48], while β-sheet was non vulnerable since it was in the stable crystalline region [49]. (3) It was confirmed that Pro impeded α-helix [50,51], while Pro, Gly, Asp, and Ser were applied more in β-turns [52,53].…”

Section: Spectral Changesmentioning

confidence: 99%

The Influence of Natural Aging Exerting on the Stability of Some Proteinaceous Binding Media Commonly Used in Painted Artworks

Yang

Wang

et al. 2022

Coatings

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Natural aging plays a key role in the degradation of proteinaceous binders which are important dispersers and stabilizers of painting layers. Knowledge about the natural aging influence on the stability of binders is important for exploring the deterioration mechanisms of painted artworks. Pig glue, whole egg, egg white, egg yolk, casein, and mixtures with ultramarine were aged for 10 years in natural conditions. GC-MS and FTIR were applied to explore the changes in the binders at a molecular level. Our experiment revealed that the less stable Met (Methionine), Lys (Lysine), Ile (Isoleucine), Ser (Serine), Asp (Aspartic acid), Glu (Glutamic acid), Hyp (Hydroxyproline), especially aromatic Phe (Phenylalanine), and Tyr (Tyrosine) were damaged, thus the contents of the stable Ala (Alanine), Gly (Glycine), Val (Valine), Leu (Leucine), and Pro (Proline) increased. The broadening of Amide A and the declining amount of α-helix, along with the increasing contents of β-sheet and random coils, all showed that the binders had transformed into disordered states. What is more, we found that pig glue had better natural aging resistance, ultramarine could speed up the aging process and lipids in egg were more easily degraded. The mechanisms of the changes of primary structures and secondary structures are also discussed in the paper.

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Section: Spectral Changesmentioning

confidence: 99%

The Influence of Natural Aging Exerting on the Stability of Some Proteinaceous Binding Media Commonly Used in Painted Artworks

Yang

Wang

et al. 2022

Coatings

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“…CDPs are indeed attracting interest as drug carriers, thanks to their demonstrated ability to cross membranes and penetrate cells [ 29 ]. Their aggregates can display fluorescence [ 30 ], and they are widely studied for their diverse biological activities [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ], which make them promising for biomedical applications, as recently reviewed [ 39 ]. Further, they are being investigated also for optoelectronic [ 40 ] and catalytic [ 41 ] applications, as biodegradable and environmentally-friendly substitutes of more traditional options.…”

Section: Introductionmentioning

confidence: 99%

Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides

Scarel

Marchesan

2021

Molecules

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Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts. They have attracted great interest in a variety of fields spanning from functional materials to drug discovery. This concise review will analyze the latest advancements in their synthesis, self-assembly into gels, and their more innovative applications.

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Cyclic Dipeptides: The Biological and Structural Landscape with Special Focus on the Anti-Cancer Proline-Based Scaffold

et al. 2021

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Cyclic dipeptides, also know as diketopiperazines (DKP), the simplest cyclic forms of peptides widespread in nature, are unsurpassed in their structural and bio-functional diversity. DKPs, especially those containing proline, due to their unique features such as, inter alia, extra-rigid conformation, high resistance to enzyme degradation, increased cell permeability, and expandable ability to bind a diverse of targets with better affinity, have emerged in the last years as biologically pre-validated platforms for the drug discovery. Recent advances have revealed their enormous potential in the development of next-generation theranostics, smart delivery systems, and biomaterials. Here, we present an updated review on the biological and structural profile of these appealing biomolecules, with a particular emphasis on those with anticancer properties, since cancers are the main cause of death all over the world. Additionally, we provide a consideration on supramolecular structuring and synthons, based on the proline-based DKP privileged scaffold, for inspiration in the design of compound libraries in search of ideal ligands, innovative self-assembled nanomaterials, and bio-functional architectures.

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Self-Assembly of Cyclic Dipeptides and Their Fluorescent Properties

Cited by 4 publications

References 0 publications

The Influence of Natural Aging Exerting on the Stability of Some Proteinaceous Binding Media Commonly Used in Painted Artworks

The Influence of Natural Aging Exerting on the Stability of Some Proteinaceous Binding Media Commonly Used in Painted Artworks

Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides

Cyclic Dipeptides: The Biological and Structural Landscape with Special Focus on the Anti-Cancer Proline-Based Scaffold

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