Self-assembly pipette tip-based cigarette filters for micro-solid phase extraction of ketoconazole cis-enantiomers in urine samples followed by high-performance liquid chromatography/diode array detection

Andrade, Roseane Teixeira; Silva, Ricky Cássio Santos da; Pereira, Arnaldo César; Borges, Keyller Bastos

doi:10.1039/c5ay00468c

Cited by 29 publications

(8 citation statements)

References 31 publications

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“…27 Analyzing the CF spectrum, the band at approximately 3500 cm À1 can be assigned to O-H stretching, 1750 cm À1 to C]O stretching and 1245 cm À1 to C-O stretching; all of these bands are characteristic of CF for being an ester with hydroxyl groups from the cellulose. 21 With the characterization of the main bands of PAni and CF, we verify that the PAni-CF composite spectrum is the sum of the PAni and CF spectra, differing only in intensity and with a small displacement of some bands owing to interference of the bands related to the separated material. From the SEM characterization ( Fig.…”

Section: Characterization Of the Adsorbents Materialsmentioning

confidence: 60%

“…19,20 Actually, it is desirable to monitor and to develop analytical methodologies to detect and control the presence of pharmaceuticals in very different kinds of samples, for example waste water, urine, serum or plasma, most of which are very complex matrices. 21,22 Thus the development of new adsorbent materials to employ in techniques of sample extraction is highly desired.…”

Section: Introductionmentioning

confidence: 99%

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Polyaniline-deposited cellulose fiber composite prepared via in situ polymerization: enhancing adsorption properties for removal of meloxicam from aqueous media

et al. 2017

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Section: Characterization Of the Adsorbents Materialsmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Polyaniline-deposited cellulose fiber composite prepared via in situ polymerization: enhancing adsorption properties for removal of meloxicam from aqueous media

et al. 2017

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“…Accordingly, 1000 μL of water samples was selected for the following experiments because it showed better recovery which was also the case with Andrade et al. .…”

Section: Resultsmentioning

confidence: 92%

Miniaturized pipette‐tip‐based electrospun polyacrylonitrile nanofibers for the micro‐solid‐phase extraction of nitro‐based explosive compounds

Tavengwa

Nyamukamba

Cukrowska

et al. 2016

J of Separation Science

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In this study, a self-assembly of miniaturized pipette-tip-based solid-phase extraction for the simultaneous extraction of nitroaromatic compounds was developed, with electrospun polyacrylonitrile nanofibers used as sorbents. The electrospun polyacrylonitrile nanofibers were characterized by scanning electron microscopy, FTIR analysis and surface area analysis. Good linearities for the four nitroaromatic compounds (2,6-dinitrotoluene, 2-nitrotoluene, 3-nitrotoluene, and 4-nitrotoluene) were obtained in a range of 250-1000 μg/L with coefficients of determination > 0.99. The limits of detection of these analytes were between 21 and 38 μg/L. The results showed that the pipette-tip-based solid-phase extraction was effective in extracting nitrotoluenes in the pH regime of environmental interest (≈ 6). The investigation also revealed that the optimum mass of electrospun polyacrylonitrile nanofibers sorbent was 15 mg and 20 aspirating/dispensing cycles gave the maximum recovery of nitrotoluenes with 200 μL acetonitrile as the best eluting solvent. Moreover, the performance of the present method was studied for the extraction and determination of nitroaromatic compounds in real environmental water samples and good recoveries ranging from 70 to 115% were found, and respective relative standard deviations of <12% were obtained.

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“…SPE is the most widely used procedure for the extraction of analytes from different samples . Several SPE approaches can be found in literature using cartridges , columns , fibers and pipette‐tips .…”

Section: Introductionmentioning

confidence: 99%

“…Selective extractions were obtained with limits of detection <0.5 μg/L. Borges and coauthors developed tip‐based pipettes on MIPs for the extraction of ketoconazole and fluoroquinolones from urine samples. The MIP selectivity was attested and the limits of detection were lower than 40 μg/L.…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted probe for solid‐phase extraction of hippuric and 4‐methylhippuric acids directly from human urine samples followed by MEKC analysis

et al. 2017

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Hippuric acid (HA) and 4-methylhippuric acid (4-MHA) are metabolites as well as biological indicators for toluene and xylenes, respectively, and their determination in urine samples is very important, in order to monitor the occupational exposition to these solvents, ensuring a safe working environment. Thus, this paper describes the synthesis and characterization of a probe impregnated with molecularly imprinted polymers (MIPs) for the solid-phase extraction of HA and 4-MHA directly from untreated urine samples followed by micellar electrokinetic chromatography (MEKC) analyses. The MIP probe selectivity was compared to the non-imprinted polymer probe. The MEKC separations were carried out in 50 mmol/L sodium tetraborate pH 10.0/0.5 mmol/L cetyltrimethylammonium bromide aqueous solution, with a constant voltage of -15 kV. The system variables were optimized to provide ideal conditions for the extraction and desorption of the analytes, as well as for the MEKC analyses. The method was linear from 0.5 to 5.0 g/L for both analytes, with correlation coefficients > 0.994. Precisions and accuracies, expressed as relative standard deviation and relative error, were < 20.0 and within -15.4 to 16.6%, respectively, in accordance with the United States Food and Drug Administration recommendation. The MIP probe has proven to be simple, cheap, resistant, and synthetically reproducible, being successfully used to analyze both HA and 4-MHA from real samples.

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Self-assembly pipette tip-based cigarette filters for micro-solid phase extraction of ketoconazole cis-enantiomers in urine samples followed by high-performance liquid chromatography/diode array detection

Abstract: A simple stereoselective HPLC/DAD method was developed for the determination of ketoconazole (KTZ) cis-enantiomers in human urine.

Cited by 29 publications

References 31 publications

Polyaniline-deposited cellulose fiber composite prepared via in situ polymerization: enhancing adsorption properties for removal of meloxicam from aqueous media

Polyaniline-deposited cellulose fiber composite prepared via in situ polymerization: enhancing adsorption properties for removal of meloxicam from aqueous media

Miniaturized pipette‐tip‐based electrospun polyacrylonitrile nanofibers for the micro‐solid‐phase extraction of nitro‐based explosive compounds

Molecularly imprinted probe for solid‐phase extraction of hippuric and 4‐methylhippuric acids directly from human urine samples followed by MEKC analysis

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